Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects

Vasudevan, R.; Ismail, Patimah; Stanslas, Johnson; Shamsudin, Norashikin; Ali, Aisyah binti

doi:10.7150/ijbs.4.362

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Int J Biol Sci 2008; 4(6):362-367. doi:10.7150/ijbs.4.362 This issue Cite

Research Paper

Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects

R. Vasudevan¹, Patimah Ismail^{1 ✉}, Johnson Stanslas¹, Norashikin Shamsudin², Aisyah binti Ali¹

1. Molecular Biology Lab, Department of Biomedical Science, Universiti Putra Malaysia, Serdang 43400, Malaysia
2. Department of Medicine, Faculty of Medicine and Health Sciences, Serdang 43400, Malaysia

Citation:

Vasudevan R, Ismail P, Stanslas J, Shamsudin N, Ali Ab. Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects. Int J Biol Sci 2008; 4(6):362-367. doi:10.7150/ijbs.4.362. https://www.ijbs.com/v04p0362.htm

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Abstract

An insertion/deletion (I/D) polymorphism of Alpha2B-Adrenoceptor (ADRA2B) gene located on chromosome 2 has been studied extensively in related to cardiovascular diseases. The main aim of the present study was to examine the potential association of D allele frequency of I/D polymorphism of ADRA2B gene in Malaysian essential hypertensive subjects with or without type 2 diabetes mellitus (T2DM). This study includes 70 hypertensive subjects without T2DM, 65 hypertensive subjects with T2DM and 75 healthy volunteers as control subjects. Genotyping of I/D polymorphism was performed by conventional PCR method. There was significant difference found in age, body mass index, systolic/diastolic blood pressure and high density lipoprotein cholesterol level between the case and control subjects. DD genotypic frequency of I/D polymorphism was significantly higher in hypertensive subjects (42.84% vs. 29.33%; P=0.029) and in hypertensive with T2DM subjects (46.15% vs. 29.33%; P=0.046) than control group. D allele frequency was higher in hypertensive group (67.41%) than control subjects (52.67%). However, no significant difference was found between the three genotypes of I/D polymorphism of ADRA2B gene and the clinical characteristics of the subjects. The result obtained in this study show D allele of ADRA2B gene was associated with essential hypertension with or without T2DM in Malaysian subjects.

Keywords: Alpha2B-Adrenoceptor, Essential hypertension, Type 2 Diabetes Mellitus, Insertion/Deletion polymorphism

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APA

Vasudevan, R., Ismail, P., Stanslas, J., Shamsudin, N., Ali, A.b. (2008). Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects. International Journal of Biological Sciences, 4(6), 362-367. https://doi.org/10.7150/ijbs.4.362.

ACS

Vasudevan, R.; Ismail, P.; Stanslas, J.; Shamsudin, N.; Ali, A.b. Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects. Int. J. Biol. Sci. 2008, 4 (6), 362-367. DOI: 10.7150/ijbs.4.362.

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CSE

Vasudevan R, Ismail P, Stanslas J, Shamsudin N, Ali Ab. 2008. Association of Insertion/Deletion Polymorphism of Alpha-Adrenoceptor Gene in Essential Hypertension with or without Type 2 Diabetes Mellitus in Malaysian Subjects. Int J Biol Sci. 4(6):362-367.

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