Int J Biol Sci 2022; 18(3):1303-1312. doi:10.7150/ijbs.66931 This issue

Review

Role of Slit/Robo Signaling pathway in Bone Metabolism

Lingyu Jiang1,2, Jianxun Sun1,2✉, Dingming Huang1,2✉

1. State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
2. Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

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Citation:
Jiang L, Sun J, Huang D. Role of Slit/Robo Signaling pathway in Bone Metabolism. Int J Biol Sci 2022; 18(3):1303-1312. doi:10.7150/ijbs.66931. Available from https://www.ijbs.com/v18p1303.htm

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Abstract

Graphic abstract

Slit/Robo signals were initially found to play an essential role in nerve development as axonal guidance molecules. In recent years, with in-depth study, the role of Slit/Robo in other life activities, such as tumor development, angiogenesis, cell migration, and bone homeostasis, has gradually been revealed. Bone is an organ with an active metabolism. Bone resorption and bone formation are closely related through precise spatiotemporal coordination. There is much evidence that slit, as a new bone coupling factor, can regulate bone formation and resorption. For example, Slit3 can promote bone formation and inhibit bone resorption through Robo receptors, which has excellent therapeutic potential in metabolic bone diseases. Although the conclusions of some studies are contradictory, they all affirm the vital role of Slit/Robo signaling in regulating bone metabolism. This paper reviews the research progress of Slit/Robo signaling in bone metabolism, briefly discusses the contradictions in the existing research, and puts forward the research direction of Slit/Robo in the field of bone metabolism in the future.

Keywords: Slit/Robo, Coupling factors, Bone Metabolism, Osteoblast, Osteoclast