The Networks of Noncoding RNAs and Their Direct Molecular Targets in Myocardial Infarction

Wang, Shiqi; Wang, Yang; Cheng, Hongxin; Zhang, Qing; Fu, Chenying; He, Chengqi; Wei, Quan

doi:10.7150/ijbs.69671

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Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

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Int J Biol Sci 2022; 18(8):3194-3208. doi:10.7150/ijbs.69671 This issue Cite

Review

The Networks of Noncoding RNAs and Their Direct Molecular Targets in Myocardial Infarction

Shiqi Wang, MMed^1,2, Yang Wang, MMed^1,2, Hongxin Cheng, BS^1,2, Qing Zhang, MMed^1,2, Chenying Fu, PhD^3,4✉, Chengqi He, MD^1,2, Quan Wei, MD^{1,2 ✉}

1. Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
2. Key Laboratory of Rehabilitation Medicine in Sichuan Province, Chengdu, Sichuan, PR China.
3. National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
4. Aging and Geriatric Mechanism Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.

Citation:

Wang S, Wang Y, Cheng H, Zhang Q, Fu C, He C, Wei Q. The Networks of Noncoding RNAs and Their Direct Molecular Targets in Myocardial Infarction. Int J Biol Sci 2022; 18(8):3194-3208. doi:10.7150/ijbs.69671. https://www.ijbs.com/v18p3194.htm

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Abstract

Noncoding RNAs are closely related to the development of myocardial infarction (MI), and their specific roles in MI are still being carefully studied. Researchers can select the literature they are interested in according to their own wishes in traditional reviews, which results in a certain amount of selection bias. A data-driven approach was used to organize this review to understand the ncRNAs in MI in the past five years. Here, we reveal important networks of interactions between noncoding RNAs and their direct targets. Our review gives an unbiased description of the role of noncoding RNAs in MI. Key information, such as carrier selection, treatment time window, treatment dose and possible side effects of ncRNA therapy, needs to be further determined. In short, the interactions between coding and noncoding genes play indispensable roles in the occurrence and development of MI and still deserve great attention from researchers in this field. The rational application of ncRNAs is expected to become a target for the treatment of MI.

Keywords: ncRNAs, miRNAs, lncRNAs, circRNAs, myocardial infarction, data-driven

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APA

Wang, S., Wang, Y., Cheng, H., Zhang, Q., Fu, C., He, C., Wei, Q. (2022). The Networks of Noncoding RNAs and Their Direct Molecular Targets in Myocardial Infarction. International Journal of Biological Sciences, 18(8), 3194-3208. https://doi.org/10.7150/ijbs.69671.

ACS

Wang, S.; Wang, Y.; Cheng, H.; Zhang, Q.; Fu, C.; He, C.; Wei, Q. The Networks of Noncoding RNAs and Their Direct Molecular Targets in Myocardial Infarction. Int. J. Biol. Sci. 2022, 18 (8), 3194-3208. DOI: 10.7150/ijbs.69671.

NLM

CSE

Wang S, Wang Y, Cheng H, Zhang Q, Fu C, He C, Wei Q. 2022. The Networks of Noncoding RNAs and Their Direct Molecular Targets in Myocardial Infarction. Int J Biol Sci. 18(8):3194-3208.

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