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Int J Biol Sci 2022; 18(8):3498-3527. doi:10.7150/ijbs.70447 This issue Cite

Review

The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers

Qing Zhang1#, Wen Wen Chen2#, Xue Sun1, Die Qian1, Dan Dan Tang1, Li Lin Zhang1, Mei Yan Li1, Lin Yu Wang1, Chun-Jie Wu1✉, Wei Peng1✉

1. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611130, P.R. China.
2. Department of Pharmacy, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610091, P.R. China.
#Co-first authors with equal contributions to this work.

✉ Corresponding authors: E-mail: wucjcdtcmcom (C.J.W); Corresponding address: School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P.R. China; Tel.: +86-028-61801001. E-mail: pengweiedu.cn (W.P); Corresp More

Citation:
Zhang Q, Chen WW, Sun X, Qian D, Tang DD, Zhang LL, Li MY, Wang LY, Wu CJ, Peng W. The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers. Int J Biol Sci 2022; 18(8):3498-3527. doi:10.7150/ijbs.70447. https://www.ijbs.com/v18p3498.htm
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Abstract

Graphic abstract

Cancers are generally recognized as the leading cause of death and a predominant barrier to prolonging life expectancy in both developed and developing countries. Emodin is a typical anthraquinone derivative from various plants that exhibits a wide spectrum of biological activities, such as anticancer, antibacterial, hepatoprotective and anti-inflammatory activities. Much previous preclinical evidence has demonstrated that emodin exhibits reliable effects on several cancer types, including lung cancer, liver cancer, colon cancer, breast cancer, pancreatic cancer, leukemia, cervical cancer, and ovarian cancer, etc. The related molecular mechanisms corresponding to the anticancer activities of emodin are involved in the induction of apoptosis, inhibition of cell proliferation, enhanced reactive oxygen species (ROS) accumulation, and induction of autophagy, etc. In the present review, we summarized the sources, anticancer properties in vitro and in vivo, molecular mechanisms, metabolic transformation and toxicities of emodin. In addition, we also discussed the limitations of the present investigations of emodin against cancers and gave some perspectives for them, which would be beneficial for the further exploration and development of this natural compound as a clinical cancer drug.

Keywords: Emodin, Apoptosis, Metastasis and invasion, Cycle arrest, Drug resistant, Autophagy

Citation styles

APA
Zhang, Q., Chen, W.W., Sun, X., Qian, D., Tang, D.D., Zhang, L.L., Li, M.Y., Wang, L.Y., Wu, C.J., Peng, W. (2022). The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers. International Journal of Biological Sciences, 18(8), 3498-3527. https://doi.org/10.7150/ijbs.70447.

ACS
Zhang, Q.; Chen, W.W.; Sun, X.; Qian, D.; Tang, D.D.; Zhang, L.L.; Li, M.Y.; Wang, L.Y.; Wu, C.J.; Peng, W. The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers. Int. J. Biol. Sci. 2022, 18 (8), 3498-3527. DOI: 10.7150/ijbs.70447.

NLM
Zhang Q, Chen WW, Sun X, Qian D, Tang DD, Zhang LL, Li MY, Wang LY, Wu CJ, Peng W. The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers. Int J Biol Sci 2022; 18(8):3498-3527. doi:10.7150/ijbs.70447. https://www.ijbs.com/v18p3498.htm

CSE
Zhang Q, Chen WW, Sun X, Qian D, Tang DD, Zhang LL, Li MY, Wang LY, Wu CJ, Peng W. 2022. The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers. Int J Biol Sci. 18(8):3498-3527.

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