Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Biol Sci 2021; 17(10):2476-2486. doi:10.7150/ijbs.59296 This issue Cite

Review

Emerging Significance and Therapeutic Potential of Extracellular vesicles

Ruhua Luo, Mengmeng Liu, Tiantian Tan, Qian Yang, Yue Wang, Lianhui Men, Liping Zhao, Honghua Zhang, Shuling Wang✉, Tian Xie✉, Qingchang Tian✉

1. College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
2. Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

✉ Corresponding authors: Shuling Wang (wsling222com), Tian Xie (xbsedu.cn), Qingchang Tian (tianqcedu.cn);

Citation:
Luo R, Liu M, Tan T, Yang Q, Wang Y, Men L, Zhao L, Zhang H, Wang S, Xie T, Tian Q. Emerging Significance and Therapeutic Potential of Extracellular vesicles. Int J Biol Sci 2021; 17(10):2476-2486. doi:10.7150/ijbs.59296. https://www.ijbs.com/v17p2476.htm
Other styles

File import instruction

Abstract

Graphic abstract

Extracellular vesicles (EVs), are membrane-bound vesicles that have many advantages over traditional nanocarriers for drug and gene delivery. Evidence from recent studies indicate that EVs have therapeutic capability with chemical or biological modification. Tumor-derived exosomes (TEXs) were used as a new type of antigens or tumor vaccines in anti-tumor immunotherapy. With superior characteristics, modified EVs were applied to loaded and delivered synthetic drugs, silencing RNA, and microRNA for treatment. Different surface functionalization strategies have been proposed to improve the therapeutic functions of EVs. Appropriately modified EVs for disease intervention provide new avenues for effective clinical treatment strategies. Therefore, this review aimed at elucidating the therapeutic functions of EVs to generate new ideas for treatment and to unlock their hidden potential in translational medicine.

Keywords: Extracellular vesicles, Exosomes, Tumor-derived exosomes, Delivery vehicles

Citation styles

APA
Luo, R., Liu, M., Tan, T., Yang, Q., Wang, Y., Men, L., Zhao, L., Zhang, H., Wang, S., Xie, T., Tian, Q. (2021). Emerging Significance and Therapeutic Potential of Extracellular vesicles. International Journal of Biological Sciences, 17(10), 2476-2486. https://doi.org/10.7150/ijbs.59296.

ACS
Luo, R.; Liu, M.; Tan, T.; Yang, Q.; Wang, Y.; Men, L.; Zhao, L.; Zhang, H.; Wang, S.; Xie, T.; Tian, Q. Emerging Significance and Therapeutic Potential of Extracellular vesicles. Int. J. Biol. Sci. 2021, 17 (10), 2476-2486. DOI: 10.7150/ijbs.59296.

NLM
Luo R, Liu M, Tan T, Yang Q, Wang Y, Men L, Zhao L, Zhang H, Wang S, Xie T, Tian Q. Emerging Significance and Therapeutic Potential of Extracellular vesicles. Int J Biol Sci 2021; 17(10):2476-2486. doi:10.7150/ijbs.59296. https://www.ijbs.com/v17p2476.htm

CSE
Luo R, Liu M, Tan T, Yang Q, Wang Y, Men L, Zhao L, Zhang H, Wang S, Xie T, Tian Q. 2021. Emerging Significance and Therapeutic Potential of Extracellular vesicles. Int J Biol Sci. 17(10):2476-2486.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use