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Volume 20 (8); 2024

Research Papers

Coenzyme Q₀ inhibited the NLRP3 inflammasome, metastasis/EMT, and Warburg effect by suppressing hypoxia-induced HIF-1α expression in HNSCC cells
Hsin-Ling Yang, Che-Wei Chang, Chithravel Vadivalagan, Sudhir Pandey, Siang-Jyun Chen, Chuan-Chen Lee, Jhih-Hsuan Hseu, You-Cheng Hseu
Int. J. Biol. Sci. 2024; 20(8): 2790-2813. doi:10.7150/ijbs.93943
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Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma
Yanru Meng, Mengxin Zhang, Xinli Li, Xinxin Wang, Qian Dong, Hu Zhang, Yuanjun Zhai, Qin Song, Fuchu He, Chunyan Tian, Aihua Sun
Int. J. Biol. Sci. 2024; 20(8): 2814-2832. doi:10.7150/ijbs.91877
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Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation
Kristina Xiao Liang, Anbin Chen, Atefeh Kianian, Cecilie Katrin Kristiansen, Tsering Yangzom, Jessica Furriol, Lena Elise Høyland, Mathias Ziegler, Torbjørn Kråkenes, Charalampos Tzoulis, Evandro Fei Fang, Gareth John Sullivan, Laurence A. Bindoff
Int. J. Biol. Sci. 2024; 20(8): 2860-2880. doi:10.7150/ijbs.93445
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Nlp-dependent ER-to-Golgi transport
Danna Yeerken, Wenchang Xiao, Jia Li, Yan Wang, Qingnan Wu, Jie Chen, Wei Gong, Mengzhu Lv, Ting Wang, Ying Gong, Rui Liu, Jiawen Fan, Jinting Li, Weimin Zhang, Qimin Zhan
Int. J. Biol. Sci. 2024; 20(8): 2881-2903. doi:10.7150/ijbs.91792
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Metallothionein 3 Potentiates Pulmonary Artery Smooth Muscle Cell Proliferation by Promoting Zinc-MTF1-ATG5 Axis-mediated Autophagosome Formation
Tianxin Xiong, Yi Li, Molin Yang, Bo Huo, Xian Guo, Liyuan Liu, Yanxin Huang, Xuehai Zhu, Qinghua Hu, Xiang Wei, Ding-Sheng Jiang, Xin Yi
Int. J. Biol. Sci. 2024; 20(8): 2904-2921. doi:10.7150/ijbs.92992
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Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12
Xianzheng Zhang, Ziwei Zhang, Yuchen Zhao, Lin Jin, Yu Tai, Yujing Tang, Shuo Geng, Han Zhang, Yufang Zhai, Yining Yang, Pin Pan, Peng He, Shuqi Fang, Chenlong Sun, Yu Chen, Mengqi Zhou, Lianghu Liu, Han Wang, Li Xu, Tianjing Zhang, Jinghan Hua, Hua Wang, Lingling Zhang
Int. J. Biol. Sci. 2024; 20(8): 2922-2942. doi:10.7150/ijbs.93242
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Endothelial Dickkopf-1 Promotes Smooth Muscle Cell-derived Foam Cell Formation via USP53-mediated Deubiquitination of SR-A During Atherosclerosis
Xiaolin Liu, Tengfei Zheng, Yu Zhang, Yachao Zhao, Fengming Liu, Shen Dai, Meng Zhang, Wencheng Zhang, Cheng Zhang, Mei Zhang, Xiao Li
Int. J. Biol. Sci. 2024; 20(8): 2943-2964. doi:10.7150/ijbs.91957
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CD8 T cells induce the peritubular capillary rarefaction during AKI to CKD transition
Wei Jiang, Tao-Tao Tang, Yi-Lin Zhang, Zuo-Lin Li, Yi Wen, Qin Yang, Yu-Qi Fu, Jing Song, Qiu-Li Wu, Min Wu, Bin Wang, Bi-Cheng Liu, Lin-Li Lv
Int. J. Biol. Sci. 2024; 20(8): 2980-2993. doi:10.7150/ijbs.96812
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Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation
Zhuoxuan Jia, Bijun Kang, Yushan Dong, Mingzhe Fan, Wei Li, Wenjie Zhang
Int. J. Biol. Sci. 2024; 20(8): 2994-3007. doi:10.7150/ijbs.92802
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SETD7 Promotes Cell Proliferation and Migration via Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma
Jinyuan Zhang, Baojun Duan, Fang Li, Xintao Jing, Rufeng Li, Shuang Cai, Li Cao, Qiuyu Jiang, Jing Zhou, Jiancheng Zhou, Yannan Qin, Xiaofei Wang, Dongdong Tong, Chen Huang
Int. J. Biol. Sci. 2024; 20(8): 3008-3027. doi:10.7150/ijbs.93201
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Nanoenabled intracellular zinc bursting for efficacious reversal of gefitinib resistance in lung cancer
Junnan Li, Yehuda G. Assaraf, Weimin Zuo, Ziqi Lin, Ka Weng Leong, Qi Zhao, Lipeng Zhu, Hang Fai Kwok
Int. J. Biol. Sci. 2024; 20(8): 3028-3045. doi:10.7150/ijbs.95929
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HDAC Inhibition Sensitize Hepatocellular Carcinoma to Lenvatinib via Suppressing AKT Activation
Shuai Yan, Lu Chen, Hao Zhuang, Hui Yang, Yinmo Yang, Ning Zhang, Rong Liu
Int. J. Biol. Sci. 2024; 20(8): 3046-3060. doi:10.7150/ijbs.93375
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Acyloxyacyl Hydrolase Protects against Kidney Injury via Inhibition of Tubular CD74-Macrophage Crosstalk
Zhenkai Wu, Bo Deng, Yuqi Shen, Xuezhu Li, Jiaolun Li, Yan Li, Shuai Ma, Yu Pan, Feng Ding
Int. J. Biol. Sci. 2024; 20(8): 3061-3075. doi:10.7150/ijbs.91237
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IFNAR(-/-) Mice Constitute a Suitable Animal Model for Epizootic Hemorrhagic Disease Virus Study and Vaccine Evaluation
Luis Jiménez-Cabello, Sergio Utrilla-Trigo, Julio Benavides-Silván, Juan Anguita, Eva Calvo-Pinilla, Javier Ortego
Int. J. Biol. Sci. 2024; 20(8): 3076-3093. doi:10.7150/ijbs.95275
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IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells
Chengcheng Yue, Yawen Hu, Jiadong Yu, Hong Zhou, Pei Zhou, Jing Hu, Xiaoyan Wang, Linna Gu, Ya Li, Yuting Feng, Fanlian Zeng, Fulei Zhao, Guolin Li, Qixiang Zhao, Chen Zhang, Huaping Zheng, Wenling Wu, Xinai Cui, Nongyu Huang, Zhen Wang, Kaijun Cui, Jiong Li
Int. J. Biol. Sci. 2024; 20(8): 3094-3112. doi:10.7150/ijbs.93843
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Particulate matter facilitates amphiregulin-dependent lung cancer proliferation through glutamine metabolism
Ya-Jing Jiang, Trung-Loc Ho, Chia-Chia Chao, Xiu-Yuan He, Po-Chun Chen, Fang-Ju Cheng, Wei-Chien Huang, Chang-Lun Huang, Po-I Liu, Chih-Hsin Tang
Int. J. Biol. Sci. 2024; 20(8): 3126-3139. doi:10.7150/ijbs.96210
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CYR61 Acts as an Intracellular Microtubule-Associated Protein and Coordinates Mitotic Progression via PLK1-FBW7 Pathway
Kaishun Hu, Limin Xie, Wenjing Wu, Jingyuan Zhang, Yu Li, Jiehua He, Yin Zhang, Daning Lu, H. Phillip Koeffler, Lehang Lin, Dong Yin
Int. J. Biol. Sci. 2024; 20(8): 3140-3155. doi:10.7150/ijbs.93335
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CPEB1 Controls NRF2 Proteostasis and Ferroptosis Susceptibility in Pancreatic Cancer
Shuxia Zhang, Jingnan Huang, Zhangzhang Lan, Yanlin Xiao, Youyou Liao, Shiva Basnet, Piying Huang, Yunze Li, Jingyu Yan, Yuling Sheng, Wenwen Zhou, Qi Liu, Haoyuan Tan, Yi Tan, Leyong Yuan, Lisheng Wang, Lingyun Dai, Wenyong Zhang, Changzheng Du
Int. J. Biol. Sci. 2024; 20(8): 3156-3172. doi:10.7150/ijbs.95962
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Exploring Splicing Modulation as an Innovative Approach to Combat Pancreatic Cancer: SF3B1 Emerges as a Prognostic Indicator and Therapeutic Target
Rocco Sciarrillo, Francesca Terrana, Annalisa Comandatore, I Gede Putu Supadmanaba, Bing Wang, Btissame El Hassouni, Giulia Mantini, Gerrit Jansen, Amir Avan, Daniela Carbone, Patrizia Diana, Godefridus J Peters, Luca Morelli, Jacqueline Cloos, Yehuda G Assaraf, Elisa Giovannetti
Int. J. Biol. Sci. 2024; 20(8): 3173-3184. doi:10.7150/ijbs.92671
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m⁶A RNA methylation drives kidney fibrosis by upregulating β-catenin signaling
Yinyi Long, Dongyan Song, Liuyan Xiao, Yadie Xiang, Dier Li, Xiaoli Sun, Xue Hong, Fan Fan Hou, Haiyan Fu, Youhua Liu
Int. J. Biol. Sci. 2024; 20(8): 3185-3200. doi:10.7150/ijbs.96233
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Hypoxic tumor-derived exosomal miR-4488 induces macrophage M2 polarization to promote liver metastasis of pancreatic neuroendocrine neoplasm through RTN3/FABP5 mediated fatty acid oxidation
Feiyu Lu, Mujie Ye, Yikai Shen, Yanling Xu, Chunhua Hu, Jinhao Chen, Ping Yu, Bingyan Xue, Danyang Gu, Lin Xu, Lingyi Chen, Yi Ding, Jianan Bai, Ye Tian, Qiyun Tang
Int. J. Biol. Sci. 2024; 20(8): 3201-3218. doi:10.7150/ijbs.96831
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Reviews

Synthetic Cells and Molecules in Cellular Immunotherapy
Haikun Lin, Chentao Li, Wanying Zhang, Boxiang Wu, Yanan Wang, Shimin Wang, Dongrui Wang, Xia Li, He Huang
Int. J. Biol. Sci. 2024; 20(8): 2833-2859. doi:10.7150/ijbs.94346
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The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer
Fabrizio Fontana, Gaia Giannitti, Sara Marchesi, Patrizia Limonta
Int. J. Biol. Sci. 2024; 20(8): 3113-3125. doi:10.7150/ijbs.89942
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Unlocking the Nexus of Sirtuins: A Comprehensive Review of Their Role in Skeletal Muscle Metabolism, Development, and Disorders
Bahareldin Ali Abdalla Gibril, Xinwei Xiong, Xuewen Chai, Qiao Xu, Jishang Gong, Jiguo Xu
Int. J. Biol. Sci. 2024; 20(8): 3219-3235. doi:10.7150/ijbs.96885
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Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications
Talha Bin Emran, Taslima Akter Eva, Mehrukh Zehravi, Fahadul Islam, Jishan Khan, Shaik Kareemulla, Uppuluri Varuna Naga Venkata Arjun, Anitha Balakrishnan, Poonam Popatrao Taru, Firzan Nainu, Emil Salim, Safia Obaidur Rab, Mohamed H. Nafady, Polrat Wilairatana, Moon Nyeo Park, Bonglee Kim
Int. J. Biol. Sci. 2024; 20(8): 3236-3256. doi:10.7150/ijbs.93875
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