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Volume 21 (2); 2025

Research Papers

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S6K1 is a Targetable Vulnerability in Tumors Exhibiting Plasticity and Therapy Resistance
Saptadwipa Ganguly, Ravshan Burikhanov, Vitaliy M. Sviripa, Sally Ellingson, Jieyun Jiang, Christian M. Gosser, David Orren, Eva M. Goellner, Gautham G. Shenoy, Mahadev Rao, John D'Orazio, Christine F. Brainson, Chang-Guo Zhan, Peter H. Spielmann, David S. Watt, Vivek M. Rangnekar
Int. J. Biol. Sci. 2025; 21(2): 454-472. doi:10.7150/ijbs.96672
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USP25 stabilizes STAT6 to promote IL-4-induced macrophage M2 polarization and fibrosis
Yahan Xu, Jing Liu, Jingzeng Wang, Jiayao Wang, Peixiang Lan, Tao Wang
Int. J. Biol. Sci. 2025; 21(2): 475-489. doi:10.7150/ijbs.99345
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Caveolin-1 mitigates the advancement of metabolic dysfunction-associated steatotic liver disease by reducing endoplasmic reticulum stress and pyroptosis through the restoration of cholesterol homeostasis
Hanlin Xu, Yu Li, Ning Guo, Shuai Wu, Can Liu, Zhongxuan Gui, Weiju Xue, Xiangfu Jiang, Mengjia Ye, Qianqian Geng, Xiaowen Feng, Chao Zhang, Lei Jin, Chengmu Hu
Int. J. Biol. Sci. 2025; 21(2): 490-506. doi:10.7150/ijbs.100794
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Smad2 Cooperating with TGIF2 Contributes to EMT and Cancer Stem Cells Properties in Pancreatic Cancer via Co-Targeting SOX2
Fuqiang Zu, ChuanPing Chen, Qilong Geng, Haoyu Li, Boyuan Chan, Guopei Luo, Mengcheng Wu, Matthias Ilmer, Bernhard W Renz, Lutterodt Bentum-Ennin, Hao Gu, Weiwei Sheng
Int. J. Biol. Sci. 2025; 21(2): 524-543. doi:10.7150/ijbs.102381
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TEAD1 Prevents Necroptosis and Inflammation in Cisplatin-Induced Acute Kidney Injury Through Maintaining Mitochondrial Function
Melanie Tran, Baihai Jiao, Hao Du, Dong Zhou, Vijay Yechoor, Yanlin Wang
Int. J. Biol. Sci. 2025; 21(2): 565-578. doi:10.7150/ijbs.104335
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Lingo1 in the hippocampus contributes to cognitive dysfunction after anesthesia and surgery in aged mice
Changliang Liu, Changteng Zhang, Ling Chen, Xin Liu, Jiahui Wu, Yalan Sun, Jin Liu, Chan Chen
Int. J. Biol. Sci. 2025; 21(2): 595-613. doi:10.7150/ijbs.98376
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HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY
Mintian Fei, Yi Zhang, Haolin Li, Qili Xu, Yu Gao, Cheng Yang, Weiyi Li, Chaozhao Liang, Baojun Wang, Haibing Xiao
Int. J. Biol. Sci. 2025; 21(2): 614-631. doi:10.7150/ijbs.103032
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TAGLN-RhoA/ROCK2-SLC2A3-mediated Mechano-metabolic Axis Promotes Skin Fibrosis
Xinwei Cheng, Zhen Gao, Jin Zhang, Hongkun Zheng, Shengzhou Shan, Jia Zhou
Int. J. Biol. Sci. 2025; 21(2): 658-670. doi:10.7150/ijbs.104484
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FAT1 knockdown enhances the CSC properties of HNSCC through p-CaMKII-mediated inactivation of the IFN pathway
Jingjing Wang, Yang Chen, Yunqing Sun, Hanzhe Liu, Ruixue Du, Xuewen Wang, Zhe Shao, Ke Liu, Zhengjun Shang
Int. J. Biol. Sci. 2025; 21(2): 671-684. doi:10.7150/ijbs.95723
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The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo
Ching-Hsuan Chou, Wei-Jan Huang, Kai-Cheng Hsu, Jui-Yi Hsu, Tony Eight Lin, Chia-Ron Yang
Int. J. Biol. Sci. 2025; 21(2): 685-707. doi:10.7150/ijbs.105826
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Downregulated CCND3 Is a Key Event Driving Lung Adenocarcinoma Metastasis during Acquired Cisplatin Resistance
Yun Su, Yuting Ma, Yubing Wang, Ping Xu, Miaoling Guo, Haolin Cao, Jianyang Xin, Xi Wu, Xiaoyan Liu, Shan Chen, Xingyu Tao, Huiling Yang, Chao Cheng, Rongquan Huang, Rongshuai Pan, Yuexin Pan, Beixian Zhou, Weiyi Fang, Zhen Liu
Int. J. Biol. Sci. 2025; 21(2): 708-724. doi:10.7150/ijbs.100921
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Mitochondrial SIRT2-mediated CPT2 deacetylation prevents diabetic cardiomyopathy by impeding cardiac fatty acid oxidation
Yaoyao Guo, Ziyin Zhang, Zheng Wen, Xiaonan Kang, Dan Wang, Lu Zhang, Mengke Cheng, Gang Yuan, Huihui Ren
Int. J. Biol. Sci. 2025; 21(2): 725-744. doi:10.7150/ijbs.102834
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Deficiency of Epithelial PIEZO1 Alleviates Liver Steatosis Induced by High-Fat Diet in Mice
Zhiyue Xu, Shu Xu, Xiaoming Liu, Lan Cheng, Xinghuang Liu, Xiaotian Xie, Dan Zhou, Dongke Wang, Jie Chen, Xiaoling Deng, Lei Zhang, Ruohang He, Ying Li, Mengmeng Cheng, Ling Yang, Xiaohua Hou, Tao Bai
Int. J. Biol. Sci. 2025; 21(2): 745-757. doi:10.7150/ijbs.102906
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FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation
Xupeng Zhao, Jichen Wang, Shuo Tian, Lu Tang, Shouqing Cao, Jiali Ye, Tianwei Cai, Yundong Xuan, Xu Zhang, Xiubin Li, Hongzhao Li
Int. J. Biol. Sci. 2025; 21(2): 758-771. doi:10.7150/ijbs.105265
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Glycine Decarboxylase Regulates Renal Carcinoma Progression via Interferon Stimulated Gene Factor 3-Mediated Pathway
Thi Tuyet Mai Pham, Mikyung Kim, Thuy Quynh Nhu Nguyen, Jae-Hyung Park, Jee In Kim, Ji Hae Seo, Jin Young Kim, Eunyoung Ha
Int. J. Biol. Sci. 2025; 21(2): 772-788. doi:10.7150/ijbs.104458
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Tubulointerstitial nephritis antigen-like 1 promotes the progression of liver fibrosis after HCV eradication with direct-acting antivirals
Lei Lei, Hu Li, Xue-Kai Wang, Jian-Rui Li, Han Sun, Hong-Ying Li, Jia-Yu Li, Mei Tang, Jing-Chen Xu, Biao Dong, Yue Gong, Dan-Qing Song, Jian-Dong Jiang, Zong-Gen Peng
Int. J. Biol. Sci. 2025; 21(2): 802-822. doi:10.7150/ijbs.103305
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Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae
Li Liu, Wanbin Hu, Fatima Didar Kerman, Herman P. Spaink
Int. J. Biol. Sci. 2025; 21(2): 823-841. doi:10.7150/ijbs.101055
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BMSCs-derived small extracellular vesicles antagonize cerebral endothelial Caveolin-1 driven autophagic degradation of tight-junction proteins to protect blood-brain barrier post-stroke
Yiyang Li, Xingping Quan, Jiacheng Hu, Yan Han, Jinfen Chen, Manfei Zhou, Fan Zhang, Yayue Yang, Mingchun Liao, Bin Wang, Yonghua Zhao
Int. J. Biol. Sci. 2025; 21(2): 842-859. doi:10.7150/ijbs.101937
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The positive feedback loop between SP1 and MAP2K2 significantly drives resistance to VEGFR inhibitors in clear cell renal cell carcinoma
Zhinan Xia, Zitong Yang, Yu Dong, Xinyu Hao, Keliang Wang, Wenjiao Xia, Liangliang Ren, Tian Li, Min Xu, Guixin Zhu, Cheng Zhang
Int. J. Biol. Sci. 2025; 21(2): 860-873. doi:10.7150/ijbs.104591
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Cold atmospheric plasma potentiates ferroptosis via EGFR(Y1068)-mediated dual axes on GPX4 among triple negative breast cancer cells
Xiaofeng Dai, Ziyao Xu, Xinyu Lv, Chao Li, Ruichen Jiang, Danjun Wang, Ming Xi, Tian Li
Int. J. Biol. Sci. 2025; 21(2): 874-892. doi:10.7150/ijbs.105455
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Reviews

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New insights into mitochondrial quality control in anthracycline-induced cardiotoxicity: molecular mechanisms, therapeutic targets, and natural products
Weili Li, Yuqin Zhang, Yan Wei, Guanjing Ling, Yawen Zhang, Yilin Li, Shujuan Guo, Nannan Tan, Lin Ma, Wei Li, Qianbin Sun, Wei Wang, Yong Wang
Int. J. Biol. Sci. 2025; 21(2): 507-523. doi:10.7150/ijbs.103810
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Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets
Jia-xin Li, Yan-miao Dang, Meng-chao Liu, Lin-qing Gao, Hui Lin
Int. J. Biol. Sci. 2025; 21(2): 544-564. doi:10.7150/ijbs.102297
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Regulation of INPP5E in Ciliogenesis, Development, and Disease
Abdulaziz Hakeem, Shuying Yang
Int. J. Biol. Sci. 2025; 21(2): 579-594. doi:10.7150/ijbs.99010
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The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease
Yi-bing Wang, Tong Li, Feng-yu Wang, Xin Yao, Qiu-xiang Bai, Hong-wei Su, Jian Liu, Li Wang, Rui-zhi Tan
Int. J. Biol. Sci. 2025; 21(2): 632-657. doi:10.7150/ijbs.104404
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Involvement of Tim-3 in Maternal-fetal Tolerance: A Review of Current Understanding
Xinhang Meng, Yujie Luo, Liyuan Cui, Songcun Wang
Int. J. Biol. Sci. 2025; 21(2): 789-801. doi:10.7150/ijbs.106115
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Erratum

Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis: Erratum
Kun Hao, Wenjiao Jiang, Mengze Zhou, Hanwen Li, Yadong Chen, Fei Jiang, Qinghua Hu
Int. J. Biol. Sci. 2025; 21(2): 473-474. doi:10.7150/ijbs.107312
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