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Volume 21 (4); 2025

Research Papers

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Ugonin P facilitates chondrogenic properties in chondrocytes by inhibiting miR-3074-5p production: implications for the treatment of arthritic disorders
Ting-Kuo Chang, Trung-Loc Ho, Yen-You Lin, Le Huynh Hoai Thuong, Kuan-Ying Lai, Chun-Hao Tsai, Chih-Chuang Liaw, Chih-Hsin Tang
Int. J. Biol. Sci. 2025; 21(4): 1378-1390. doi:10.7150/ijbs.108789
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N6-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4
Jiansheng Zhang, Mengzhu Zhang, Aimin Qiu, Chang Li, Qiongju Chen, Jianjun Li, Yuanyuan Zeng, Jianjie Zhu, Jian-an Huang, Xiuqin Zhang, Zeyi Liu
Int. J. Biol. Sci. 2025; 21(4): 1391-1409. doi:10.7150/ijbs.104097
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SEC61G Facilitates Brain Metastases via Antagonizing PGAM1 Ubiquitination and Immune Microenvironment Remodeling in Non-Small Cell Lung Cancer
Changshuai Zhou, Yuechao Yang, Huanhuan Cui, Sen Li, Zhisu Wang, Lei Chen, Mingtao Feng, Deheng Li, Xin Chen, Bin Hao, Xiaojun Wu, Yang Gao, Liangdong Li, Jiayan Chen, Yiqun Cao
Int. J. Biol. Sci. 2025; 21(4): 1436-1458. doi:10.7150/ijbs.109187
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Hexokinase 2 Suppression Alleviates the Catabolic Properties in Osteoarthritis via HMGA2 and Contributes to Pulsed Electromagnetic Field-mediated Cartilage Protection
Chuncha Bao, Siyi Zhu, Dejiang Pang, Ming Yang, Jiapeng Huang, Fengsheng Wang, Yue Hou, Xiangxiu Wang, Yuan Feng, Haolun Yang, Junliang Jiang, Jing He, Chengqi He
Int. J. Biol. Sci. 2025; 21(4): 1459-1477. doi:10.7150/ijbs.101597
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FTO-induced APOE promotes the malignant progression of pancreatic neuroendocrine neoplasms through FASN-mediated lipid metabolism
Jinhao Chen, Mujie Ye, Danyang Gu, Ping Yu, Lin Xu, Bingyang Xue, Lijun Yan, Feiyu Lu, Chunhua Hu, Yanling Xu, Xiaoting Shi, Lingyi Chen, Yan Wang, Jianan Bai, Ye Tian, Qiyun Tang
Int. J. Biol. Sci. 2025; 21(4): 1478-1496. doi:10.7150/ijbs.103428
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Solobacterium moorei promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer
Yan Chen, Ying Qin, Tingting Fan, Cheng Qiu, Yijie Zhang, Mengmeng Dai, Yaoyao Zhou, Qinsheng Sun, Yuan Guo, Yue Hao, Yuyang Jiang
Int. J. Biol. Sci. 2025; 21(4): 1497-1512. doi:10.7150/ijbs.102742
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Inhibition of GRK2-PDE4D Axis Suppresses Fibroblast-Like Synoviocytes Hyperplasia and Alleviates Experimental Arthritis
Dafei Han, Hanfei Sun, Renhao Zhang, Hui Ge, Paipai Guo, Rui Chu, Ruhong Fang, Yongsheng Han, Shufang He, Rui Li, Jiajie Tu, Wei Wei, Yang Ma, Qingtong Wang
Int. J. Biol. Sci. 2025; 21(4): 1513-1529. doi:10.7150/ijbs.100176
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DARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy
Dongqing Li, Hang Su, Xiaolin Deng, Yuan Huang, Zihuan Wang, Jinge Zhang, Chen Chen, Zaosong Zheng, Qiong Wang, Shanchao Zhao, Zhe-Sheng Chen, Haiyong Chen, Lina Hou, Wanlong Tan, Fei Li
Int. J. Biol. Sci. 2025; 21(4): 1530-1544. doi:10.7150/ijbs.107632
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High-dose Ascorbate Exhibits Anti-proliferative and Anti-invasive Effects Dependent on PTEN/AKT/mTOR Pathway in Endometrial Cancer in vitro and in vivo
Xiaochang Shen, Jiandong Wang, Weimin Kong, Catherine John, Boer Deng, Shuning Chen, Haomeng Zhang, Jennifer Haag, Nikita Sinha, Wenchuan Sun, Angeles Alvarez Secord, Chunxiao Zhou, Victoria L Bae-Jump
Int. J. Biol. Sci. 2025; 21(4): 1545-1565. doi:10.7150/ijbs.102079
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Mannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis
Haoyi Jin, Huanghe He, Jijia Li, Xi Liu, Qi Cai, Jiang Shi, Zhexue Hao, Jianxing He
Int. J. Biol. Sci. 2025; 21(4): 1566-1584. doi:10.7150/ijbs.107256
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DNMT3a promotes LUAD cell proliferation and metastasis by activating the HDAC7 signalling pathway
Menglong Jiang, Xin Zhou, Yingtong Feng, Peng Ding, Jinfeng Li, Di Lu, Jiapei Qin, Yibing Bai, An Wang, Chunfang Xia, Jinliang Wang, Xiaolong Yan, Zhiqiang Ma, Renquan Zhang
Int. J. Biol. Sci. 2025; 21(4): 1585-1602. doi:10.7150/ijbs.96509
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Prp19/CDC5L promotes gastric cancer via activation of the MAPK pathway-mediated homologous recombination
Shengkui Qiu, Feiran Wang, Xuesong Gao, Weiyu Guan, Ting Dai, Lei Yin, Fei Wang, Jinjie Sun, Peng Guo, Hao Wu, Shichun Feng, Chong Tang
Int. J. Biol. Sci. 2025; 21(4): 1603-1618. doi:10.7150/ijbs.101962
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Chloroquine Suppresses Colorectal Cancer Progression via Targeting CHKA and PFKM to inhibit the PI3K/AKT Pathway and the Warburg Effect
Yanqing Liu, Yongping Zhu, Liwei Gu, Kexin Li, Ang Ma, Li Liu, Yuqing Meng, Junzhe Zhang, Shengnan Shen, Qiaoli Shi, Dandan Liu, Xinwei Zhang, Shujie Zhang, Xin Chai, Peng Gao, Jiale Xing, Yaxu Wang, Honglin Chen, Rui Liu, Qingfeng Du, Haitao Liu, Lingyun Dai, Jigang Wang
Int. J. Biol. Sci. 2025; 21(4): 1619-1631. doi:10.7150/ijbs.101921
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BAP31-ELAVL1-SPINK6 axis induces loss of cell polarity and promotes metastasis in hepatocellular carcinoma
Xiyang Zhang, Jing Wang, Xiaohua Liang, Dongbo Jiang, Yuanjie Sun, Chenchen Hu, Feiming Hu, Yuanli He, Yubo Sun, Junqi Zhang, Jiaqi Ding, Sirui Cai, Yueyue Wang, Shuya Yang, Kun Yang
Int. J. Biol. Sci. 2025; 21(4): 1632-1648. doi:10.7150/ijbs.102566
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BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2
Song Li, Danni Luo, Yulin Liang, Yi Zou, Hongxu Pu, Meng Zheng, Yuting Wang, Xuying Sun, Hao Zhu, Yuanli Zhu, Liming Zhao, Jun Xiao
Int. J. Biol. Sci. 2025; 21(4): 1666-1685. doi:10.7150/ijbs.100396
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Prolonged DEHP exposure enhances the stemness and metastatic potential of TNBC cells in an MSI2-dependent manner
Mahendra Jadhao, Sheng-Kai Hsu, Dhanashri Deshmukh, Pei-Feng Liu, Shih-Feng Weng, Yih-Fung Chen, Chia-Yang Li, Chia-Yih Wang, Eing-Mei Tsai, Li-Fang Wang, Chien-Chih Chiu
Int. J. Biol. Sci. 2025; 21(4): 1705-1729. doi:10.7150/ijbs.101598
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Disulfiram/copper triggers cGAS-STING innate immunity pathway via ROS-induced DNA damage that potentiates antitumor response to PD-1 checkpoint blockade
Mengmeng Yuan, Liang Shi, Yan Liu, Ke Xiang, Yan Zhang, Ye Zhou, Jianling Wang, Meiju Ji, Peng Hou
Int. J. Biol. Sci. 2025; 21(4): 1730-1748. doi:10.7150/ijbs.105575
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Febuxostat therapy improved the outcomes of cardiorenal syndrome rodent through alleviating xanthine oxidase-induced oxidative stress and mitochondrial dysfunction
Chih-Chao Yang, Ya Yue, Yi-Ling Chen, John Y. Chiang, Yi-Ting Wang, Chi-Ruei Huang, Ben-Chung Cheng, Tsuen-Wei Hsu, Hon-Kan Yip
Int. J. Biol. Sci. 2025; 21(4): 1749-1766. doi:10.7150/ijbs.99194
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The E3 ubiquitin ligase MAEA promotes macrophage phagocytosis and inhibits gastrointestinal cancer progression by mediating PARP1 ubiquitination and degradation
Yanchun Feng, Xiangcai Zou, Jintuan Huang, Zhenze Huang, Guanghao Kuang, Yingming Jiang
Int. J. Biol. Sci. 2025; 21(4): 1784-1800. doi:10.7150/ijbs.102796
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FBXW7 Directly Ubiquitinates and Degrades CTNNB1 Mediating the Suppression of ENKUR in Endometrial Cancer
YaHui Liu, Qian Wang, QiRun Guo, Ying Zhu, Li Lin, ChunYan Yang, Bin Gong, Weiwei Yan, RenTao Hou, Yao Tang, XiuQiong Wu, Xinhui Liu, BeiXian Zhou, WeiYi Fang, LuYun Shu, SuiQun Guo
Int. J. Biol. Sci. 2025; 21(4): 1801-1818. doi:10.7150/ijbs.104067
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METTL3-mediated m6A modification of SLC7A11 enhances nasopharyngeal carcinoma radioresistance by inhibiting ferroptosis
Zili Dai, Baisheng Lin, Maohua Qin, Yunen Lin, Li Wang, Kai Liao, Guofeng Xie, Feixiang Wang, Jian Zhang
Int. J. Biol. Sci. 2025; 21(4): 1837-1851. doi:10.7150/ijbs.100518
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Reviews

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Bispecific antibodies as powerful immunotherapeutic agents for urological cancers: Recent innovations based on preclinical and clinical evidence
Kiavash Hushmandi, Behzad Einollahi, E Hui Clarissa Lee, Reo Sakaizawa, Antonino Glaviano, Russel J. Reiter, Seyed Hassan Saadat, Marzieh Ramezani Farani, Yun Suk Huh, Amir Reza Aref, Shokooh Salimimoghadam, Alan Prem Kumar
Int. J. Biol. Sci. 2025; 21(4): 1410-1435. doi:10.7150/ijbs.96155
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Modulation of TGF-β signaling new approaches toward kidney disease and fibrosis therapy
Quan Hong, Hyoungnae Kim, Guang-Yan Cai, Xiang-Mei Chen, John Cijiang He, Kyung Lee
Int. J. Biol. Sci. 2025; 21(4): 1649-1665. doi:10.7150/ijbs.101548
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Antibody-dependent enhancement of coronaviruses
Tao Tao, Lili Tian, Jiayi Ke, Chuxie Zhang, Maochen Li, Xiaolong Xu, Junfen Fan, Yigang Tong, Huahao Fan
Int. J. Biol. Sci. 2025; 21(4): 1686-1704. doi:10.7150/ijbs.96112
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The Role of Mitochondrial Quality Control in Liver Diseases: Dawn of a Therapeutic Era
Jia Li, Wenqin Liu, Jie Zhang, Chao Sun
Int. J. Biol. Sci. 2025; 21(4): 1767-1783. doi:10.7150/ijbs.107777
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Breaking Immunosuppression to Enhance Cancer Stem Cell-Targeted Immunotherapy
Fang Zheng, Shan Zhang, Alfred E. Chang, James J. Moon, Max S. Wicha, Shelley Xuelai Wang, Junhui Chen, Jixian Liu, Fanjun Cheng, Qiao Li
Int. J. Biol. Sci. 2025; 21(4): 1819-1836. doi:10.7150/ijbs.101025
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