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Volume 22 (3); 2026

Research Papers

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β3-adrenergic receptor agonist causes acute thermogenic metabolic crisis in ACSS1-K635Q knock-in mice
E. Sandra Chocron, David Zhang, Bushra Sumawi, Joseph Schell, Diego Cruz, Guannan Li, Prethish Sreenivas, Haiyan Jiang, Felix F. Dong, Erin Munkácsy, Shangang Zhao, Maria A. Gonzalez Porras, David Gius
Int. J. Biol. Sci. 2026; 22(3): 1070-1081. doi:10.7150/ijbs.122643
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Combining sorafenib with spermine and sphingosine synergistically enhances anticancer efficacy by modulating metabolic pathways and gut microbiome in hepatocellular carcinoma
Hay-Ran Jang, Hyun-Jin Kim, Bo-Young Kim, Jae-Hoon Jeong, Jeon-Kyung Kim, Jin Ah Won, Hye Hyun Yoo, Yong Gu Lee, Hyungshin Yim
Int. J. Biol. Sci. 2026; 22(3): 1082-1102. doi:10.7150/ijbs.118753
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TM4SF5-mediated KEAP1 Regulation in Hepatocytes Irrelevant to NRF2 Expression and Activity Promotes Oxidative Stress and Inflammation to Develop Metabolic Dysfunction-Associated Steatotic Liver Disease
Eun-Ae Shin, Haesong Lee, Kyung-hee Pyo, Wonsik Kim, Soyeon Kim, Jae-Ho Lee, Seo Hee Jin, Eunmi Kim, Soo-Min Byeon, Dong Joo Kim, Young Jun Cho, Tae Won Kim, Minjae Ohn, Hyojung Lee, Jeongwon Lee, Jinwook Jeong, Doojin Kim, Jie Zheng, Han Ah Lee, Hwi Young Kim, Young-Joon Surh, Jung Weon Lee
Int. J. Biol. Sci. 2026; 22(3): 1103-1125. doi:10.7150/ijbs.126251
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Nicotinamide N-Methyl Transferase (NNMT) Sustains Innate Sensitivity to NAMPT Inhibition in YAP-dependent Stem-like/Mesenchymal Prostate Cancer
Ágata Sofia Assunção Carreira, Marianna Ciuffreda, Nathakan Thongon, Charles M. Haughey, Adam Pickard, Sharon L. Eddie, Rebecca E. Steele, Elena Cerri, Romina Belli, Daniele Peroni, Elisa Facen, Irene Caffa, Moustafa Ghanem, Alessio Nencioni, Andrea Lunardi, Toma Tebaldi, Ian G. Mills, Alessandro Provenzani
Int. J. Biol. Sci. 2026; 22(3): 1126-1141. doi:10.7150/ijbs.120532
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Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered Bok mRNA degradation
Hong Ding, Wen-Xuan Wang, Qiong-Dan Liang, Chuan-Feng Tang, Tang-Di Xu, Zi-An Miao, Bang-Xing Han, Ling-Dong Kong
Int. J. Biol. Sci. 2026; 22(3): 1162-1185. doi:10.7150/ijbs.120307
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Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression
Mingshu Long, Yang Chen, Ruixue Du, Jiejie Yang, Jingjing Wang, Yunqing Sun, Xuezhang Tian, Shaowei Wang, Yunhong Zhong, Weilian Liang, Junjie Zhang, Zhengjun Shang
Int. J. Biol. Sci. 2026; 22(3): 1186-1206. doi:10.7150/ijbs.123790
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Targeting CDC42 Protects Mitochondrial Function through KLF2/HIF-1α/PINK1 Signaling in Acute Kidney Injury
Xue Zhou, Xian Fu, Yi-Wen Meng, Ping Dai, Qing Jiang, Hou-Hua Yin, Qing-Jin Pan, Ai-Zhi Lin, Kai-Di Ni, Zi-Guo Luo, Ru-Yu Liang, Yi-Yu Chen, Hai-Xin Yuan, Jun-Yan Liu
Int. J. Biol. Sci. 2026; 22(3): 1247-1265. doi:10.7150/ijbs.125930
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Targeting c-Myc-p300-CARM1 complex induces ferroptosis and reduces CD8+ T cell exhaustion in esophageal squamous cell carcinoma
Yuhao Wang, Yang Li, Guanzhu Ren, Jin Zhou, Wangtianjiao Chen, Kai Zhang, Xiao Yu, Yin Yin, Ji Cong, Lei Ma, Xinyao Zheng, Yahui Zhao, Zhihua Liu
Int. J. Biol. Sci. 2026; 22(3): 1266-1282. doi:10.7150/ijbs.114575
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Sema3dhi Fibroblasts Promote Acute Kidney Injury Fibrotic Progression Through Confining Endothelial Cell Migration
Qiuyu Xie, Xiaohong Xin, Weijian Yao, Zehua Li, Yuanyuan Ma, Lei Qu, Yiyi Ma, Chengang Xiang, Suxia Wang, Gang Liu, Ying Chen, Li Yang
Int. J. Biol. Sci. 2026; 22(3): 1283-1305. doi:10.7150/ijbs.124971
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Loss of UFL1 confers enzalutamide resistance of prostate tumors by regulating METTL16-mediated m6A modification of EEF1A1 mRNA
Xu Wu, Hui Gao, Qianfeng Zhuang, Feng Li, Xingliang Feng, Naiyuan Shao, Wei Zhang, Yuyang Zhang, Xiansheng Zhang
Int. J. Biol. Sci. 2026; 22(3): 1306-1321. doi:10.7150/ijbs.124214
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Metformin Sensitizes PTEN-deficient Prostate Cancer to PARP Inhibitors by Rebuilding NADP+ Homeostasis
Xiaodong Hao, Zheng Chao, Hao Peng, Xiangdong Guo, Shuo Zheng, Chunyu Zhang, Hao Ding, Yanan Wang, Zirui Xi, Yuan Gao, Guanyu Qu, Yao Zhu, Zhiqiang Chen, Peixiang Lan, Le Li, Zhihua Wang
Int. J. Biol. Sci. 2026; 22(3): 1346-1368. doi:10.7150/ijbs.121033
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Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia through the nAChR-α7/PDPK1/YAP pathway
Yunmi Cho, Ha Gyeong Kim, Ju-Hee Kang, Eun-Taex Oh, Heon Joo Park
Int. J. Biol. Sci. 2026; 22(3): 1369-1388. doi:10.7150/ijbs.117013
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Immune Cell Infiltration and Kynurenine Pathway Activation Define Early Injury and Progression in Diabetic Nephropathy
Yi-Chun Tsai, Chia-Yen Dai, Ming-Ju Tsai, Shang-Jyh Hwang, Ping-Shaou Yu, Wei-Wen Hung, Sheng-Feng Pan, Ling-Yu Wu, Pei-Hsun Tsai, Hung-Pei Tsai, Wei-An Chang, Ya-Ling Hsu
Int. J. Biol. Sci. 2026; 22(3): 1389-1406. doi:10.7150/ijbs.122164
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Chronic Stress Induces Hepatic Steatosis via Brain-Hepatic Sympathetic Axis Mediated Catecholamine Resistance
Shanshan Wu, Jiachen Liu, Shanshan Huang, Yuxin Guo, Yan Bi
Int. J. Biol. Sci. 2026; 22(3): 1407-1424. doi:10.7150/ijbs.126058
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Klotho-derived peptide 1 ameliorates hepatic fibrosis induced by αKlotho deficiency and liver injury
Huishi Tan, Wenshu Huang, Hanying Luo, Wenjian Min, Xiaoyao Zhang, Xiaoli Sun, Enqing Lin, Xue Hong, Peng Yang, Lili Zhou, Youhua Liu
Int. J. Biol. Sci. 2026; 22(3): 1425-1439. doi:10.7150/ijbs.122107
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The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4
Yuan Jiang, Zhenhao Zhao, Peng Li, Guangsong Su, Yuyang Qian, Yuting Zhao, Bo Wang, Yunlong Bai, Lei Zhang, Zhongfang Zhao, Jiandang Shi, Wange Lu
Int. J. Biol. Sci. 2026; 22(3): 1440-1460. doi:10.7150/ijbs.124731
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FBXL8 Stabilizes IκBα and Negatively Regulated NF-κB Activation to Suppress Pancreatic Cancer Progression
Chunming Li, Kui Fu, Feifan Wu, Zhihao Fan, Yongpeng Gu, Chaohua Zhang, Qin Lang, Zhu Zhu, Xiong Ding, Jianping Gong, Junhua Gong
Int. J. Biol. Sci. 2026; 22(3): 1461-1479. doi:10.7150/ijbs.122689
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Classic Protocadherin PCDH10 Functions as a Tumor Suppressive Scaffold Protein Antagonizing Oncogenic WNT/β-catenin Signaling in Breast Carcinogenesis
Xiaoyu Wang, Yiqing Tan, Yuanyuan Wang, Lili Li, Tingxiu Xiang, Yongheng Chen, Weiyan Peng, Zhu Qiu, Hongzhong Li, Guosheng Ren, Qian Tao
Int. J. Biol. Sci. 2026; 22(3): 1480-1495. doi:10.7150/ijbs.127857
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Novel GS5 sericin mitigates UVA-induced photoaging by activating Nrf2 and inhibiting the JAK-STAT pathway
Haiqiong Guo, Yueting Sun, Wenyu Shi, Rui Huang, Qingxiu He, Ping Zhao, Qingyou Xia
Int. J. Biol. Sci. 2026; 22(3): 1496-1519. doi:10.7150/ijbs.123702
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The Interaction of CircESR1 and HNRNPAB Regulates Cell Cycle Transition of Breast Cancer Cell
Junchao Xu, Qiao Xu, Tingfang Cao, Miaomiao Wang, Yinzhong Shang, Junyan Tang, Sheng Wu, Xiaopeng Ma, Xinghua Han, Peter E. Lobie, Liting Qian, Tao Zhu
Int. J. Biol. Sci. 2026; 22(3): 1520-1541. doi:10.7150/ijbs.126014
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Elaidic acid suppresses hepatocellular carcinoma growth through modulating the production of intestinal Ligilactobacillus murinus-derived spermidine
Yini Li, Tongtong Tian, Qian Yu, Huiqin Jiang, Te Liu, Hao Wang, Ran Huo, Chenzheng Gu, Yu Liu, Ying Zhao, Chunyan Zhang, Yan Zhou, Jiyan Wang, Lin Ding, Chuyu Wang, Xinyi He, Wei Guo, Wenjing Yang, Beili Wang
Int. J. Biol. Sci. 2026; 22(3): 1542-1559. doi:10.7150/ijbs.122392
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NUDT7 Modulates the UBA52-SREBF1 Signaling Axis to Promote PRRSV Replication via Lipid Synthesis
Yuchao Yan, Changyan Li, Junyang Zhang, Ruiqiao Li, Boxuan Yin, Sicheng Zhang, Yinhao Zhang, Xinyi Zhang, Jun Han, Jinhai Huang
Int. J. Biol. Sci. 2026; 22(3): 1590-1610. doi:10.7150/ijbs.127844
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CircCLMP Suppresses Anti-Tumor Immunity by Inhibiting Activation of IRF3 and Interferon Response in Microsatellite Instability-high Endometrial Cancer
Weijia Wen, Li Yuan, Peng Guo, Xueyuan Zhao, Linna Chen, Songlin Liu, Haolin Fan, Lin Lin, Yu Pan, Shiyi Chen, Yifang Xiao, Pan Liu, Dongyun Wang, Hongye Jiang, Wei Wang, Chunyu Zhang, Shuzhong Yao
Int. J. Biol. Sci. 2026; 22(3): 1611-1631. doi:10.7150/ijbs.125547
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GSTA1 deficiency drives neuroendocrine differentiation via TNFRSF13B/c-FOS/CHGA axis in prostate cancer
Jiajun Qian, Yang Luo, Yao Fu, Wenli Diao, Qiubo Ding, Wei Chen, Xuefeng Qiu, Hongqian Guo
Int. J. Biol. Sci. 2026; 22(3): 1632-1647. doi:10.7150/ijbs.120497
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Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination
Xiaohan Guo, Yuxin Lin, Yue Jiang, Meihui Wang, Yang Li, Yuanyuan Gao, Bocen Chen, Zhengyang Bao, Haoyuan Tian, Xiaomao Chu, Zili Zhang, Jiangjuan Shao, Feng Zhang, Huali Wang, Ji Xuan, Xuefen Xu, Shizhong Zheng
Int. J. Biol. Sci. 2026; 22(3): 1648-1673. doi:10.7150/ijbs.125009
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Reviews

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Microbiota-Gut-Kidney Axis and Targeted Therapeutic Strategies in Kidney Diseases
Zheng-hao Sun, Qian Gong, Zi-lai Wang, Chao Li, Jia-nan Wang, Ju-tao Yu, Ming-lu Ji, Dan-feng Zhang, Jie Wei, Shuai-shuai Xie, Fang-jie Zhou, Xiang-yu Li, Xiao-guo Suo, Qi Zhu, Juan Jin, Wei Shao, Pei Pan, Xiao-ming Meng
Int. J. Biol. Sci. 2026; 22(3): 1142-1161. doi:10.7150/ijbs.124499
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The Role of Estrogen Signaling Pathway and Targeted Therapy Exploration in Urological Tumors
Cunzhen Ma, Lin Yang, Weijia Li, Wentai Shangguan, Wenxue Huang, Zhuohang Li, Boyuan Sun, Xunguo Yang, Haoxiang Xu, Zhibiao Li, Peidan Peng, Zongwei Wang, Peng Wu, Bisheng Cheng
Int. J. Biol. Sci. 2026; 22(3): 1207-1232. doi:10.7150/ijbs.123812
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Exploring huntington's disease from a neurodevelopmental perspective
Chunhui Huang, Xiao Zheng, Wei Li, Zaijun Zhang, Shihua Li, Xiao-Jiang Li, Mingdeng Rong, Sen Yan
Int. J. Biol. Sci. 2026; 22(3): 1233-1246. doi:10.7150/ijbs.124552
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The Immunogenetic Landscape of Allergic Rhinitis: from Cellular Effectors to Gene Regulation and Targeted Therapies
Xu Zhang, Zhiqiang Zhang, Qian Peng, Xinyu Huang, Mengyuan Liu, Daoming Bai, Rui Yang, Yun Zhang, Chunping Yang
Int. J. Biol. Sci. 2026; 22(3): 1322-1345. doi:10.7150/ijbs.126788
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Light as a Weapon: Redefining Cancer Care with Photodynamic Therapy
Kulsoom X, Wajahat Ali, Yue Chong, Zhenlong Wang, Li Xue, Fu Wang
Int. J. Biol. Sci. 2026; 22(3): 1560-1588. doi:10.7150/ijbs.125584
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