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Research Paper
Ligand-receptor interaction atlas within and between tumor cells and T cells in lung adenocarcinoma
Zhencong Chen, Xiaodong Yang, Guoshu Bi, Jiaqi Liang, Zhengyang Hu, Mengnan Zhao, Ming Li, Tao Lu, Yuansheng Zheng, Qihai Sui, Yong Yang, Cheng Zhan, Wei Jiang, Qun Wang, Lijie Tan
Int. J. Biol. Sci. 2020; 16(12): 2205-2219. doi:10.7150/ijbs.42080
[Abstract] [Full text] [PDF]


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Research Paper
Targeting ERα degradation by L-Tetrahydropalmatine provides a novel strategy for breast cancer treatment
Xiaohong Xia, Jinchan He, Bin Liu, Zhenlong Shao, Qiong Xu, Tumei Hu, Cuifu Yu, Xiaolin Liu, Yuning Liao, Ningning Liu, Hongbiao Huang
Int. J. Biol. Sci. 2020; 16(12): 2192-2204. doi:10.7150/ijbs.44005
[Abstract] [Full text] [PDF]


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Research Paper
SETDB2 promoted breast cancer stem cell maintenance by interaction with and stabilization of ΔNp63α protein
Liu Ying, Xie Fei, Li Jialun, Xiao Jianpeng, Wang Jie, Mei Zhaolin, Fan Hongjia, Fang Huan, Li Sha, Wu Qiuju, Yuan Lin, Liu Cuicui, Peng You, Zhao Weiwei, Wang Lulu, Wong Jiemin, Li Jing, Feng Jing
Int. J. Biol. Sci. 2020; 16(12): 2180-2191. doi:10.7150/ijbs.43611
[Abstract] [Full text] [PDF]


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Research Paper
Long-term UVA exposure to the eye compromises memory and learning ability in mice via corticotropin-releasing hormone type 2 receptor
Keiichi Hiramoto, Yurika Yamate
Int. J. Biol. Sci. 2020; 16(12): 2170-2179. doi:10.7150/ijbs.45967
[Abstract] [Full text] [PDF]


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Research Paper
MicroRNA-4516 suppresses pancreatic cancer development via negatively regulating orthodenticle homeobox 1
Shuo Chen, Meng Xu, Jing Zhao, Jiaqi Shen, Junhui Li, Yang Liu, Gang Cao, Jiancang Ma, Weizhou He, Xi Chen, Tao Shan
Int. J. Biol. Sci. 2020; 16(12): 2159-2169. doi:10.7150/ijbs.45933
[Abstract] [Full text] [PDF]


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Research Paper
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair
Shan Peng, Yingming Sun, Yuan Luo, Shijing Ma, Wenjie Sun, Guiliang Tang, Shuying Li, Nannan Zhang, Jiangbo Ren, Yu Xiao, Xuefeng Liu, Junhong Zhang, Yan Gong, Conghua Xie
Int. J. Biol. Sci. 2020; 16(12): 2145-2158. doi:10.7150/ijbs.46194
[Abstract] [Full text] [PDF]


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Research Paper
Circ-100290 Positively Regulates Angiogenesis Induced by Conditioned Medium of Human Amnion-Derived Mesenchymal Stem Cells Through miR-449a/eNOS and miR-449a/VEGFA Axes
Zichun Tang, Xiaoyue Wu, Liping Hu, Yijing Xiao, Junling Tan, Siyu Zuo, Ming Shen, Xiaoqin Yuan
Int. J. Biol. Sci. 2020; 16(12): 2131-2144. doi:10.7150/ijbs.39895
[Abstract] [Full text] [PDF]


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Research Paper
Inflammation and DNA methylation coregulate the CtBP-PCAF-c-MYC transcriptional complex to activate the expression of a long non-coding RNA CASC2 in acute pancreatitis
Jun Zeng, Jian-Yong Chen, Jun Meng, Zhi Chen
Int. J. Biol. Sci. 2020; 16(12): 2116-2130. doi:10.7150/ijbs.43557
[Abstract] [Full text] [PDF]


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Research Paper
5-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion
Qingli Lu, Yuan Ding, Yang Li, Qingli Lu
Int. J. Biol. Sci. 2020; 16(12): 2104-2115. doi:10.7150/ijbs.44906
[Abstract] [Full text] [PDF]


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Review
Emerging Roles of Long non-coding RNAs in The Tumor Microenvironment
Lisha Zhou, Yingying Zhu, Dongsheng Sun, Qiang Zhang
Int. J. Biol. Sci. 2020; 16(12): 2094-2103. doi:10.7150/ijbs.44420
[Abstract] [Full text] [PDF]


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Research Paper
ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer
Huijuan Zeng, Tianfu Li, Duanyang Zhai, Jiong Bi, Xiaying Kuang, Sihong Lu, Zhen Shan, Ying Lin
Int. J. Biol. Sci. 2020; 16(12): 2084-2093. doi:10.7150/ijbs.44204
[Abstract] [Full text] [PDF]


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Research Paper
Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma
Fei Xue, Mengzhu Yu, Li Li, Wenzhe Zhang, Yongbin Ma, Liyang Dong, Wenqi Shan, Yu Zheng, Ting Wang, Dingqi Feng, Jianping Lv, Xuefeng Wang
Int. J. Biol. Sci. 2020; 16(12): 2072-2083. doi:10.7150/ijbs.43596
[Abstract] [Full text] [PDF]


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Research Paper
KLF10 inhibits cell growth by regulating PTTG1 in multiple myeloma under the regulation of microRNA-106b-5p
Mimi Zhou, Jinqiu Chen, Hui Zhang, Hailing Liu, Huan Yao, Xiaman Wang, Wanggang Zhang, Yingren Zhao, Nan Yang
Int. J. Biol. Sci. 2020; 16(12): 2063-2071. doi:10.7150/ijbs.45999
[Abstract] [Full text] [PDF]


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Research Paper
RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation
Ling Ren, Tingting Zhou, Yang Wang, Yanmei Wu, Hongde Xu, Jingwei Liu, Xiang Dong, Fei Yi, Qiqiang Guo, Zhuo Wang, Xiaoman Li, Ning Bai, Wendong Guo, Min Guo, Bo Jiang, Xuan Wu, Yanling Feng, Xiaoyu Song, Siyi Zhang, Yue Zhao, Liu Cao, Shuai Han, Chengzhong Xing
Int. J. Biol. Sci. 2020; 16(12): 2051-2062. doi:10.7150/ijbs.44119
[Abstract] [Full text] [PDF]


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Review
Role of Pyroptosis in Traumatic Brain and Spinal Cord Injuries
Xinli Hu, Huanwen Chen, Hui Xu, Yaosen Wu, Chenyu Wu, Chang Jia, Yao Li, Sunren Sheng, Cong Xu, Huazi Xu, Wenfei Ni, Kailiang Zhou
Int. J. Biol. Sci. 2020; 16(12): 2042-2050. doi:10.7150/ijbs.45467
[Abstract] [Full text] [PDF]


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Review
How DNA methylation affects the Warburg effect
Xingxin Zhu, Zefeng Xuan, Jun Chen, Zequn Li, Shusen Zheng, Penghong Song
Int. J. Biol. Sci. 2020; 16(12): 2029-2041. doi:10.7150/ijbs.45420
[Abstract] [Full text] [PDF]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
crispRdesignR: A Versatile Guide RNA Design Package in R for CRISPR/Cas9 Applications
Dylan Beeber, Frédéric JJ Chain
J. Genomics 2020; 8: 62-70. doi:10.7150/jgen.41196
[Abstract] [Full text] [PDF]


Research Paper
Draft genome sequence of Actinomadura sp. K4S16 and elucidation of the nonthmicin biosynthetic pathway
Hisayuki Komaki, Enjuro Harunari, Natsuko Ichikawa, Akira Hosoyama, Moriyuki Hamada, Kannika Duangmal, Arinthip Thamchaipenet, Yasuhiro Igarashi
J. Genomics 2020; 8: 53-61. doi:10.7150/jgen.44650
[Abstract] [Full text] [PDF]


Short Research Paper
Complete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka
Indika Seneviratha, Dinesha Jayasundara, Joshua P. Lefler, Kira L. Chaiboonm, Janith Warnasekara, Suneth Agampodi, Michael A. Matthias, Joseph M. Vinetz
J. Genomics 2020; 8: 49-52. doi:10.7150/jgen.43953
[Abstract] [Full text] [PDF]


Research Paper
A detailed characteristics of bias associated with long runs of homozygosity identification based on medium density SNP microarrays
Tomasz Szmatoła, Artur Gurgul, Igor Jasielczuk, Weiwei Fu, Katarzyna Ropka-Molik
J. Genomics 2020; 8: 43-48. doi:10.7150/jgen.39147
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details