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Int J Biol Sci 2024; 20(5):1602-1616. doi:10.7150/ijbs.85526 This issue Cite

Research Paper

PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation

Jiangcheng Shu1,2, Shu Yan1,2, Chenhui Ju1,2, Long Chen2, Minglu Liang2, Cheng Wang2,3✉, Kai Huang1,2✉

1. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
2. Clinic Center of Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
3. Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

✉ Corresponding authors: Cheng Wang, MD, PhD, Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan, Hubei 430022, China; Email: cwangunionedu.cn. Kai Huang, MD More

Citation:
Shu J, Yan S, Ju C, Chen L, Liang M, Wang C, Huang K. PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation. Int J Biol Sci 2024; 20(5):1602-1616. doi:10.7150/ijbs.85526. https://www.ijbs.com/v20p1602.htm
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Abstract

Graphic abstract

Myocardial infarction causes cardiomyocyte loss, and depleted cardiomyocyte proliferative capacity after birth impinges the heart repair process, eventually leading to heart failure. This study aims to investigate the role of Poly(ADP-Ribose) Polymerase 1 (PARP1) in the regulation of cardiomyocyte proliferation and heart regeneration. Our findings demonstrated that PARP1 knockout impaired cardiomyocyte proliferation, cardiac function, and scar formation, while PARP1 overexpression improved heart regeneration in apical resection-operated mice. Mechanistically, we found that PARP1 interacts with and poly(ADP-ribosyl)ates Heat Shock Protein 90 Alpha Family Class B Member 1 (HSP90AB1) and increases binding between HSP90AB1 and Cell Division Cycle 37 (CDC37) and cell cycle kinase activity, thus activating cardiomyocyte cell cycle. Our results reveal that PARP1 promotes heart regeneration and cardiomyocyte proliferation via poly(ADP-ribosyl)ation of HSP90AB1 activating the cardiomyocyte cell cycle, suggesting that PARP1 may be a potential therapeutic target in treating cardiac injury.

Keywords: cardiomyocyte proliferation, heart regeneration, cell cycle, cell signaling, PARP1

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APA
Shu, J., Yan, S., Ju, C., Chen, L., Liang, M., Wang, C., Huang, K. (2024). PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation. International Journal of Biological Sciences, 20(5), 1602-1616. https://doi.org/10.7150/ijbs.85526.

ACS
Shu, J.; Yan, S.; Ju, C.; Chen, L.; Liang, M.; Wang, C.; Huang, K. PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation. Int. J. Biol. Sci. 2024, 20 (5), 1602-1616. DOI: 10.7150/ijbs.85526.

NLM
Shu J, Yan S, Ju C, Chen L, Liang M, Wang C, Huang K. PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation. Int J Biol Sci 2024; 20(5):1602-1616. doi:10.7150/ijbs.85526. https://www.ijbs.com/v20p1602.htm

CSE
Shu J, Yan S, Ju C, Chen L, Liang M, Wang C, Huang K. 2024. PARP1 Promotes Heart Regeneration and Cardiomyocyte Proliferation. Int J Biol Sci. 20(5):1602-1616.

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