Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease

Yong Soon Chun, Pooja Chaudhari, Yoon-Young Jang^✉

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.

Citation:
Chun YS, Chaudhari P, Jang YY. Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease. Int J Biol Sci 2010; 6(7):796-805. doi:10.7150/ijbs.6.796. Available from https://www.ijbs.com/v06p0796.htm

Abstract

The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ectoderm- tissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/drug discovery, gene therapy and cell replacement therapy.

Keywords: Stem Cell, Disease Modeling, Drug Screening, Liver Disease