A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!

Guo, Zhiyong; Qiu, Yun

doi:10.7150/ijbs.7.815

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Theranostics

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Int J Biol Sci 2011; 7(6):815-822. doi:10.7150/ijbs.7.815 This issue Cite

Review

A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!

Zhiyong Guo, Yun Qiu^✉

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA

Citation:

Guo Z, Qiu Y. A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!. Int J Biol Sci 2011; 7(6):815-822. doi:10.7150/ijbs.7.815. https://www.ijbs.com/v07p0815.htm

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Abstract

Prostate cancer is the second leading cause of cancer-related death in American men. Although most prostate cancers are initially androgen-dependent and respond to androgen ablation therapy, majority of them eventually relapse and progress into incurable castration-resistant (or hormone refractory) prostate cancer. The underlying mechanisms are the focus of intensive investigation for development of more effective treatment. Mounting evidence from both clinical and basic research has demonstrated that the activity of the androgen receptor (AR) is still required for castration-resistant prostate cancer. Multiple mechanisms by which AR is re-activated under androgen-depleted conditions may be involved in the development of castration resistance. The recent identification of AR splicing variants may add another layer of complexity in AR biology. The present review summarizes recent progress in study of AR splicing variants in prostate cancer.

Keywords: androgen receptor, prostate cancer, splicing variants, alternative splicing.

Citation styles

APA

Guo, Z., Qiu, Y. (2011). A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!. International Journal of Biological Sciences, 7(6), 815-822. https://doi.org/10.7150/ijbs.7.815.

ACS

Guo, Z.; Qiu, Y. A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!. Int. J. Biol. Sci. 2011, 7 (6), 815-822. DOI: 10.7150/ijbs.7.815.

NLM

Guo Z, Qiu Y. A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!. Int J Biol Sci 2011; 7(6):815-822. doi:10.7150/ijbs.7.815. https://www.ijbs.com/v07p0815.htm

CSE

Guo Z, Qiu Y. 2011. A New Trick of an Old Molecule: Androgen Receptor Splice Variants Taking the Stage?!. Int J Biol Sci. 7(6):815-822.

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