Serum Bone Alkaline Phosphatase in Assessing Illness Severity of Infected Neonates in the Neonatal Intensive Care Unit

Zhang, Yaozong; Xue, Chenguang; Zhu, Tian; Du, Xiaolan; Su, Nan; Qi, Huabing; Yang, Jing; Shi, Yuan; Chen, Lin

doi:10.7150/ijbs.8.30



Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

Global reach, higher impact

Full Text | PDF

Int J Biol Sci 2012; 8(1):30-38. doi:10.7150/ijbs.8.30 This issue Cite

Research Paper

Serum Bone Alkaline Phosphatase in Assessing Illness Severity of Infected Neonates in the Neonatal Intensive Care Unit

Yaozong Zhang¹, Chenguang Xue², Tian Zhu³, Xiaolan Du¹, Nan Su¹, Huabing Qi¹, Jing Yang¹, Yuan Shi³, Lin Chen^{1 ✉}

1. State Key Laboratory of Trauma, Burns and Combined Injury, Center of Bone Metabolism and Repair, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China
2. NICU of Children's Hospital of Baoding City, Baoding, China
3. Department of Pediatrics, Daping Hospital, Third Military Medical University, Chongqing, China

Citation:

Zhang Y, Xue C, Zhu T, Du X, Su N, Qi H, Yang J, Shi Y, Chen L. Serum Bone Alkaline Phosphatase in Assessing Illness Severity of Infected Neonates in the Neonatal Intensive Care Unit. Int J Biol Sci 2012; 8(1):30-38. doi:10.7150/ijbs.8.30. https://www.ijbs.com/v08p0030.htm

Other styles

Abstract

Background: Infections can influence bone metabolism of neonates, which may lead to changes in some bone metabolism biomarkers. The purpose of this study was to determine whether serum bone alkaline phosphatase (BALP), osteocalcin (OC) and beta carboxy-terminal peptide of type I collagen (CTX), as specific biomarkers of bone metabolism, can be used to assess the severity of neonatal infections.

Methods: Sixty-three neonates in the NICU were enrolled in this study. The neonates were divided into infected group (n=33) and non-infected group (n=30). The scores for neonatal acute physiology-perinatal extension II (SNAPPE-II) were calculated and interleukin-6 (IL-6), procalcitonin (PCT), BALP, OC and CTX were measured among the neonates with or without infections, and among the infected neonates before and after treatment.

Results: The serum BALP levels were lower in the infected group than that in the non-infected group (p<0.01). The serum BALP levels increased markedly in the infected neonates after treatment (p<0.01). The serum BALP levels were also inversely correlated with SNAPPE-II of infected neonates before and after treatment (r=-0.56, p<0.05; r=-0.37, p<0.05, respectively). In infected neonates, the differences between serum BALP levels before and after treatment were inversely correlated with those of IL-6 levels (p<0.05). There were no significant changes in the OC, CTX and PCT levels in the infected or non-infected group before and after treatment.

Conclusion: Our data suggest that serum BALP level might be used as a marker for assessing the severity of illness in infected neonates.

Keywords: Bone alkaline phosphatase, bone, severity, infection, neonates

Citation styles

APA

Zhang, Y., Xue, C., Zhu, T., Du, X., Su, N., Qi, H., Yang, J., Shi, Y., Chen, L. (2012). Serum Bone Alkaline Phosphatase in Assessing Illness Severity of Infected Neonates in the Neonatal Intensive Care Unit. International Journal of Biological Sciences, 8(1), 30-38. https://doi.org/10.7150/ijbs.8.30.

ACS

Zhang, Y.; Xue, C.; Zhu, T.; Du, X.; Su, N.; Qi, H.; Yang, J.; Shi, Y.; Chen, L. Serum Bone Alkaline Phosphatase in Assessing Illness Severity of Infected Neonates in the Neonatal Intensive Care Unit. Int. J. Biol. Sci. 2012, 8 (1), 30-38. DOI: 10.7150/ijbs.8.30.

NLM

CSE

Zhang Y, Xue C, Zhu T, Du X, Su N, Qi H, Yang J, Shi Y, Chen L. 2012. Serum Bone Alkaline Phosphatase in Assessing Illness Severity of Infected Neonates in the Neonatal Intensive Care Unit. Int J Biol Sci. 8(1):30-38.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.