Association between the C.1161G>A and C.1779C>G Genetic Variants of <i>XRCC1</i> Gene and Hepatocellular Carcinoma Risk in Chinese Population

Deng, Xin; Liang, Jian; Jiang, Majun; Zhou, Xiaoxiao; Liu, Hongdan

doi:10.7150/ijbs.5928

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International Journal of Medical Sciences

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Int J Biol Sci 2013; 9(3):289-294. doi:10.7150/ijbs.5928 This issue Cite

Research Paper

Association between the C.1161G>A and C.1779C>G Genetic Variants of XRCC1 Gene and Hepatocellular Carcinoma Risk in Chinese Population

Xin Deng, Jian Liang^✉, Majun Jiang, Xiaoxiao Zhou, Hongdan Liu

Department of Oncology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.

Citation:

Deng X, Liang J, Jiang M, Zhou X, Liu H. Association between the C.1161G>A and C.1779C>G Genetic Variants of XRCC1 Gene and Hepatocellular Carcinoma Risk in Chinese Population. Int J Biol Sci 2013; 9(3):289-294. doi:10.7150/ijbs.5928. https://www.ijbs.com/v09p0289.htm

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Abstract

The human X-ray repair complementing group 1 gene (XRCC1) is an important candidate gene influencing hepatocellular carcinoma (HCC) susceptibility. The objective of this study was to detect the association between c.1161G>A and c.1779C>G variants of XRCC1 gene and HCC risk. This study was conducted in Chinese population consisting of 623 HCC cases and 639 controls. These two genetic variants could be genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The association of XRCC1 gene variants with the risk of HCC was investigated under different genetic models. Our findings suggested that the genotypes/alleles from c.1161G>A and c.1779C>G genetic variants were statistically associated with HCC risk. As for the c.1161G>A, the AA genotype was statistically associated with the increased risk of HCC compared to GG wild genotype (OR = 2.36, 95% CI 1.63-3.40, P < 0.001). As for the c.1779C>G, the risk of HCC was significantly higher for GG genotype compared to CC wild genotype (OR = 2.17, 95% CI 1.51-3.12, P < 0.001). Furthermore, significant differences in the risk of HCC were also detected in other genetic models for these two variants. The allele-A of c.1161G>A and allele-G of c.1779C>G variants may contribute to the susceptibility of HCC (A versus G: OR = 1.48, 95% CI 1.26-1.75, P < 0.001 and G versus C: OR = 1.51, 95% CI 1.28-1.78, P < 0.001). Our data indicated that these two variants of XRCC1 gene were statistically associated with HCC risk in Chinese population.

Keywords: Hepatocellular carcinoma, XRCC1 gene, genetic variants, molecular markers, susceptibility, risk factors.

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APA

Deng, X., Liang, J., Jiang, M., Zhou, X., Liu, H. (2013). Association between the C.1161G>A and C.1779C>G Genetic Variants of XRCC1 Gene and Hepatocellular Carcinoma Risk in Chinese Population. International Journal of Biological Sciences, 9(3), 289-294. https://doi.org/10.7150/ijbs.5928.

ACS

Deng, X.; Liang, J.; Jiang, M.; Zhou, X.; Liu, H. Association between the C.1161G>A and C.1779C>G Genetic Variants of XRCC1 Gene and Hepatocellular Carcinoma Risk in Chinese Population. Int. J. Biol. Sci. 2013, 9 (3), 289-294. DOI: 10.7150/ijbs.5928.

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CSE

Deng X, Liang J, Jiang M, Zhou X, Liu H. 2013. Association between the C.1161G>A and C.1779C>G Genetic Variants of XRCC1 Gene and Hepatocellular Carcinoma Risk in Chinese Population. Int J Biol Sci. 9(3):289-294.

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