Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer

Wang, Feng-wei; Guan, Xin-yuan; Xie, Dan

doi:10.7150/ijbs.7191

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Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

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Int J Biol Sci 2013; 9(10):1013-1020. doi:10.7150/ijbs.7191 This issue Cite

Review

Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer

Feng-wei Wang¹, Xin-yuan Guan², Dan Xie^1✉

1. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China. Collaborative Innovation Center of Cancer Medicine.
2. Department of Clinical Oncology, the University of Hong Kong, Hong Kong, China.

Citation:

Wang Fw, Guan Xy, Xie D. Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer. Int J Biol Sci 2013; 9(10):1013-1020. doi:10.7150/ijbs.7191. https://www.ijbs.com/v09p1013.htm

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Abstract

Eukaryotic initiation factor 5A (eIF5A), the only known cellular protein containing the amino acid hypusine, is an essential component of translation elongation. eIF5A2, one of the two isoforms in the eIF5A family, is reported to be a novel oncogenic protein in many types of human cancer. Both in vitro and in vivo studies showed that eIF5A2 could initiate tumor formation, enhance cancer cell growth, and increase cancer cell motility and metastasis by inducing epithelial-mesenchymal transition. Accumulatied evidence suggests that eIF5A2 is a useful biomarker in the prediction of cancer prognoses and serves as an anticancer molecular target. In this review, we will focus on updating current knowledge of the EIF5A2 gene in human cancers. The molecular mechanisms of EIF5A2 related to tumorigenesis will also be discussed.

Keywords: Eukaryotic initiation factor 5A2, Cancer, Epithelial-mesenchymal transition, Metastasis.

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APA

Wang, F.w., Guan, X.y., Xie, D. (2013). Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer. International Journal of Biological Sciences, 9(10), 1013-1020. https://doi.org/10.7150/ijbs.7191.

ACS

Wang, F.w.; Guan, X.y.; Xie, D. Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer. Int. J. Biol. Sci. 2013, 9 (10), 1013-1020. DOI: 10.7150/ijbs.7191.

NLM

Wang Fw, Guan Xy, Xie D. Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer. Int J Biol Sci 2013; 9(10):1013-1020. doi:10.7150/ijbs.7191. https://www.ijbs.com/v09p1013.htm

CSE

Wang Fw, Guan Xy, Xie D. 2013. Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer. Int J Biol Sci. 9(10):1013-1020.

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