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Int J Biol Sci 2019; 15(11):2419-2426. doi:10.7150/ijbs.37008 This issue Cite

Review

The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer

Jingchen Jing1,2, Bo Wang1,2, Peijun Liu1,2✉

1. Center for Translational Medicine, The First Affiliated Hospital, Xi'an Jiaotong University
2. The Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

✉ Corresponding author: Dr. Peijun Liu, Center for Translational Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi 710061, China. E‑mail: liupeijunxjtu.edu.cn

Citation:
Jing J, Wang B, Liu P. The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer. Int J Biol Sci 2019; 15(11):2419-2426. doi:10.7150/ijbs.37008. https://www.ijbs.com/v15p2419.htm
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Abstract

Graphic abstract

SEC23, the core component of the coat protein complex II (COPII), functions to transport newly synthesized proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus in cells for secretion. SEC23 protein has two isoforms (SEC23A and SEC23B) and their aberrant expression and mutations were reported to cause human diseases and oncogenesis, whereas SEC23A and SEC23B may have the opposite activity in human cancer, for a reason that remains unclear. This review summarizes recent research in SEC23, COPII-vesicle transportation, autophagy, and cancer.

Keywords: SEC23, COPII-vesicle transportation, autophagy, cancer

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APA
Jing, J., Wang, B., Liu, P. (2019). The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer. International Journal of Biological Sciences, 15(11), 2419-2426. https://doi.org/10.7150/ijbs.37008.

ACS
Jing, J.; Wang, B.; Liu, P. The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer. Int. J. Biol. Sci. 2019, 15 (11), 2419-2426. DOI: 10.7150/ijbs.37008.

NLM
Jing J, Wang B, Liu P. The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer. Int J Biol Sci 2019; 15(11):2419-2426. doi:10.7150/ijbs.37008. https://www.ijbs.com/v15p2419.htm

CSE
Jing J, Wang B, Liu P. 2019. The Functional Role of SEC23 in Vesicle Transportation, Autophagy and Cancer. Int J Biol Sci. 15(11):2419-2426.

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