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Int J Biol Sci 2020; 16(1):49-60. doi:10.7150/ijbs.36073 This issue Cite

Research Paper

PM2.5 exposure induces vascular dysfunction via NO generated by iNOS in lung of ApoE-/- mouse

Min-Hui Long1*, Xiao-Ming Zhu1*, Qin Wang2, Yao Chen1, Xiang-Dong Gan1, Fei Li1, Wen-Liang Fu1, Wei-Wei Xing1, Dong-Qun Xu2✉, Dong-Gang Xu1✉

1. Institute of Military Cognitive and Brain Sciences, Beijing, 100850, China
2. National Institute of Environmental Health Chinese Center for Disease Control and Prevention, Beijing, 100021, China
*Co-First Author

✉ Corresponding author: Dong-Gang Xu, E-mail: xudgac.cn; Dong-Qun Xu, E-mail: dongqunxucom.

Citation:
Long MH, Zhu XM, Wang Q, Chen Y, Gan XD, Li F, Fu WL, Xing WW, Xu DQ, Xu DG. PM2.5 exposure induces vascular dysfunction via NO generated by iNOS in lung of ApoE-/- mouse. Int J Biol Sci 2020; 16(1):49-60. doi:10.7150/ijbs.36073. https://www.ijbs.com/v16p0049.htm
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Abstract

Graphic abstract

PM2.5 exposure exacerbates cardiovascular diseases via oxidative stress and inflammation, the detailed mechanism of which is unclear. In this study, the effects of oxidative stress and inflammation, as well as vascular structure and function were studied by multiple PM2.5 exposure model of ApoE-/- mice. The results indicated that NO produced by iNOS not cNOS might play important roles in inducing vascular dysfunction after PM2.5 exposure. The occurrence order and causality among NO, other oxidative stress indicators and inflammation is explored by single PM2.5 exposure. The results showed that NO generated by iNOS occurred earlier than that of other oxidative stress indicators, which was followed by the increased inflammation. Inhibition of NOS could effectively block the raise of NO, oxidative stress and inflammation after PM2.5 exposure. All in all, we firstly confirmed that NO was the initiation factor of PM2.5 exposure-induced oxidative stress, which led to inflammation and the following vascular dysfunction.

Keywords: PM2.5 exposure, iNOS, Oxidative stress, Inflammation, Vascular function

Citation styles

APA
Long, M.H., Zhu, X.M., Wang, Q., Chen, Y., Gan, X.D., Li, F., Fu, W.L., Xing, W.W., Xu, D.Q., Xu, D.G. (2020). PM2.5 exposure induces vascular dysfunction via NO generated by iNOS in lung of ApoE-/- mouse. International Journal of Biological Sciences, 16(1), 49-60. https://doi.org/10.7150/ijbs.36073.

ACS
Long, M.H.; Zhu, X.M.; Wang, Q.; Chen, Y.; Gan, X.D.; Li, F.; Fu, W.L.; Xing, W.W.; Xu, D.Q.; Xu, D.G. PM2.5 exposure induces vascular dysfunction via NO generated by iNOS in lung of ApoE-/- mouse. Int. J. Biol. Sci. 2020, 16 (1), 49-60. DOI: 10.7150/ijbs.36073.

NLM
Long MH, Zhu XM, Wang Q, Chen Y, Gan XD, Li F, Fu WL, Xing WW, Xu DQ, Xu DG. PM2.5 exposure induces vascular dysfunction via NO generated by iNOS in lung of ApoE-/- mouse. Int J Biol Sci 2020; 16(1):49-60. doi:10.7150/ijbs.36073. https://www.ijbs.com/v16p0049.htm

CSE
Long MH, Zhu XM, Wang Q, Chen Y, Gan XD, Li F, Fu WL, Xing WW, Xu DQ, Xu DG. 2020. PM2.5 exposure induces vascular dysfunction via NO generated by iNOS in lung of ApoE-/- mouse. Int J Biol Sci. 16(1):49-60.

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