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Int J Biol Sci 2020; 16(13):2379-2381. doi:10.7150/ijbs.49433 This issue Cite

Erratum

Andrographolide Suppress Tumor Growth by Inhibiting TLR4/NF-κB Signaling Activation in Insulinoma: Erratum

Qian-Qian Zhang^1*, Yi Ding^1*, Yan Lei¹, Cui-Ling Qi¹, Xiao-Dong He¹, Tian Lan¹, Jiang-Chao Li¹, Ping Gong¹, Xuesong Yang³, Jian-Guo Geng² , Li-Jing Wang¹

1. Vascular Biology Research Institute, Guangdong Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou 510006, China.
2. Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
3. Department of Histology and Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Medical College of Jinan University, Guangzhou 510632, China.
* These authors contributed equally to this work.

Corrected-article in Int J Biol Sci, Volume 10, 404

In our paper [1], Due to the authors made an error p50 IHC figure in Figure 4B and error TLR4, MyD88 and p65 IHC figures in Figure 5B. The authors would like to apologize for any inconvenience caused to the readers by these changes. Through repeated confirmation, we confirmed that we attached the wrong IHC figures due to mislabeling the storage photos while taking photos. We redone the IHC assay and confirmed that the results were in accordance with the published results. It is important to state that this correction do not affect our study's results in the published paper. The 40× and 100× original figures of p50 during tumor development and TLR4, MyD88 and p65 in Mock, DMSO- or Andro-treated groups were attached as supplementary figures. I would like to declare on behalf of my co-authors that all authors have seen and approved the Erratum being submitted. Figure 4 and Figure 5 should be corrected as follows.

 Figure 4 

The expression and activation of TLR4/NF-κB signaling is increased during insulinoma development. (A) The classification of insulinoma. The H&E staining defined the stages of insulinoma. (B) The immunohistochemical staining of TLR4, MyD88, p50, p65 and phosphorylated p65 (Ser276) at the stage of normal, hyperplasia, angiogenic islet, insulinoma, and invasive carcinoma in RIP1-Tag2 mice. Results are representative of at least 3 tissue samples in a mouse from more than 3 mice for each stage. Bar, 20 μm.

 Figure 5 

Andro targets TLR4/NF-κB signaling in insulinoma. Andro can significantly inhibited the protein expression of TLR4, MyD88, phosphorylated IκBα, p65, phosphorylated p65 (Ser536), and phosphorylated p65 (Ser276) of TLR4/NF-κB signaling pathway in tumor tissues of RIP1-Tag2 mice compared with control groups. Immunohistochemical staining showed that Andro also inhibited the expression of TLR4 (B), MyD88 (C) and p65 (D) in tumor tissues of RIP1-Tag2 mice compared with control groups. Bar, 20 μm. ***P < 0.001.

References

1. Zhang QQ, Ding Y, Lei Y, Qi CL, He XD, Lan T, Li JC, Gong P, Yang X, Geng JG, Wang LJ. Andrographolide suppress tumor growth by inhibiting TLR4/NF-κB signaling activation in insulinoma. International Journal of Biological Sciences. 2014;10(4):404-14 doi: 10.7150/ijbs.7723

Author contact

Corresponding authors: Li-Jing Wang, phone: 86-20-39352231, fax: 86-20-39352397, wanglijingedu.cn; and Jian-Guo Geng, phone: 86-20-39352231, fax: 86-20-39352397, genglabcom.

Published 2020-6-25

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