COVID-19: Insight into the asymptomatic SARS-COV-2 infection and transmission

Han, Dongsheng; Li, Rui; Han, Yanxi; Zhang, Rui; Li, Jinming

doi:10.7150/ijbs.48991



Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

Global reach, higher impact

Full Text | PDF

Int J Biol Sci 2020; 16(15):2803-2811. doi:10.7150/ijbs.48991 This issue Cite

Review

COVID-19: Insight into the asymptomatic SARS-COV-2 infection and transmission

Dongsheng Han^1,2,3*, Rui Li^1,2,3*, Yanxi Han^1,2,3, Rui Zhang^1,3, Jinming Li^1,2,3✉

1. National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P.R. China.
2. Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P.R. China.
3. Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, P.R. China.
*These authors contributed equally to the work.

Citation:

Han D, Li R, Han Y, Zhang R, Li J. COVID-19: Insight into the asymptomatic SARS-COV-2 infection and transmission. Int J Biol Sci 2020; 16(15):2803-2811. doi:10.7150/ijbs.48991. https://www.ijbs.com/v16p2803.htm

Other styles

Abstract

The existence of a substantial but unclear number of asymptomatic SARS-COV-2 patients worldwide has raised concerns among global public health authorities. In this review, according to the published literature, we provided the evidence that asymptomatic infections can result in person-to-person transmission. Four studies suggested that the virus can be transmitted by asymptomatic patients for at least two consecutive generations, indicating its strong infectivity. Asymptomatic infection tends to be, but is not only, identified among young people (<20 years old). The majority of asymptomatic patients appear to have a milder clinical course during hospitalization, but the severity of the symptoms of the secondary patients infected by SARS-COV-2 from asymptomatic patients varies with their physical constitution. The proportion of asymptomatic individuals among all confirmed cases widely differed (from 1.95% to 87.9%) according to the study setting and the populations studied. The increasing large-scale tests are expected to give more information about the true number of asymptomatic infections in the population. In China and other countries, various guidelines for management of asymptomatic cases have been issued. Importantly, early detection, early reporting, early isolation and early treatment of asymptomatic patients require the joint efforts of policy makers, clinicians, technicians, epidemiologists, virologists and patients.

Keywords: SARS-COV-2, asymptomatic infection, serological assays, social distancing

Citation styles

APA

Han, D., Li, R., Han, Y., Zhang, R., Li, J. (2020). COVID-19: Insight into the asymptomatic SARS-COV-2 infection and transmission. International Journal of Biological Sciences, 16(15), 2803-2811. https://doi.org/10.7150/ijbs.48991.

ACS

Han, D.; Li, R.; Han, Y.; Zhang, R.; Li, J. COVID-19: Insight into the asymptomatic SARS-COV-2 infection and transmission. Int. J. Biol. Sci. 2020, 16 (15), 2803-2811. DOI: 10.7150/ijbs.48991.

NLM

CSE

Han D, Li R, Han Y, Zhang R, Li J. 2020. COVID-19: Insight into the asymptomatic SARS-COV-2 infection and transmission. Int J Biol Sci. 16(15):2803-2811.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.