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Int J Biol Sci 2022; 18(3):901-910. doi:10.7150/ijbs.64993 This issue Cite

Review

Human Organoids as a Promising Platform for Fighting COVID-19

Dong Chen1, Xi Su1, Haibo Chen2, Siyan Chen3, Yongsheng Zhao2✉, Wei Wei1✉

1. Department of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
2. Department of Nuclear Medicine, Peking University Shenzhen Hospital, Shenzhen 518036, China.
3. College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.

✉ Corresponding author: Yongsheng Zhao, Department of Nuclear Medicine, Peking University Shenzhen Hospital, No.1120, Lianhua Road, Futian District, Shenzhen 518036, China. E-mail: zhaoys69com; Wei Wei, Department of Thyroid and Breast Surgery, P More

Citation:
Chen D, Su X, Chen H, Chen S, Zhao Y, Wei W. Human Organoids as a Promising Platform for Fighting COVID-19. Int J Biol Sci 2022; 18(3):901-910. doi:10.7150/ijbs.64993. https://www.ijbs.com/v18p0901.htm
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Abstract

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The coronavirus disease 2019 (COVID-19) global pandemic evoked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a major public health problem with significant morbidity and mortality. Understanding the pathogenesis and molecular mechanisms underlying this novel virus is crucial for both fundamental research and clinical trials in order to devise effective therapies and vaccination regimens. Basic research on SARS-CoV-2 largely depends on ex vivo models that allow viral invasion and replication. Organoid models are now emerging as a valuable tool to investigate viral biology and disease progression, serving as an efficient platform to investigate potential therapies for COVID-19. Here, we summarize various human stem cell-derived organoid types employed in SARS-CoV-2 studies. We highlight key findings from these models, including cell tropisms and molecular mechanisms in viral infection. We also describe their use in identifying potential therapeutic agents against SARS-CoV-2. As more and more advanced organoids emerge, they will facilitate the understanding of disease pathogenesis for drug development in this dreaded pandemic.

Keywords: organoid, SARS-CoV-2, COVID-19, infection, drug screening

Citation styles

APA
Chen, D., Su, X., Chen, H., Chen, S., Zhao, Y., Wei, W. (2022). Human Organoids as a Promising Platform for Fighting COVID-19. International Journal of Biological Sciences, 18(3), 901-910. https://doi.org/10.7150/ijbs.64993.

ACS
Chen, D.; Su, X.; Chen, H.; Chen, S.; Zhao, Y.; Wei, W. Human Organoids as a Promising Platform for Fighting COVID-19. Int. J. Biol. Sci. 2022, 18 (3), 901-910. DOI: 10.7150/ijbs.64993.

NLM
Chen D, Su X, Chen H, Chen S, Zhao Y, Wei W. Human Organoids as a Promising Platform for Fighting COVID-19. Int J Biol Sci 2022; 18(3):901-910. doi:10.7150/ijbs.64993. https://www.ijbs.com/v18p0901.htm

CSE
Chen D, Su X, Chen H, Chen S, Zhao Y, Wei W. 2022. Human Organoids as a Promising Platform for Fighting COVID-19. Int J Biol Sci. 18(3):901-910.

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