Int J Biol Sci 2022; 18(3):970-982. doi:10.7150/ijbs.65979 This issue Cite

Review

CARD9 Regulation and its Role in Cardiovascular Diseases

Haina Zhang1,2, Yeling Wang1, Hongbo Men1,2, Wenqian Zhou1,2, Shanshan Zhou1, Quan Liu1✉, Lu Cai2,3✉

1. Department of Cardiovascular Diseases, First Hospital of Jilin University, Jilin University, Changchun, 130021, China.
2. Pediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.
3. Departments of Radiation Oncology, Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40202, USA.

Citation:
Zhang H, Wang Y, Men H, Zhou W, Zhou S, Liu Q, Cai L. CARD9 Regulation and its Role in Cardiovascular Diseases. Int J Biol Sci 2022; 18(3):970-982. doi:10.7150/ijbs.65979. https://www.ijbs.com/v18p0970.htm
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Abstract

Graphic abstract

Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor protein expressed on myeloid cells and located downstream of pattern recognition receptors (PRRs), which transduces signals involved in innate immunity. CARD9 deficiency is associated with increased susceptibility to various fungal diseases. Increasing evidence shows that CARD9 mediates the activation of p38 MAPK, NF-κB, and NLRP3 inflammasome in various CVDs and then promotes the production of proinflammatory cytokines and chemokines, which contribute to cardiac remodeling and cardiac dysfunction in certain cardiovascular diseases (CVDs). Moreover, CARD9-mediated anti-apoptosis and autophagy are implicated in the progression of CVDs. Here, we summarize the structure and function of CARD9 in innate immunity and its various roles in inflammation, apoptosis, and autophagy in the pathogenesis of CVDs. Furthermore, we discuss the potential therapies targeting CARD9 to prevent CVDs and raise some issues for further exploring the role of CARD9 in CVDs.

Keywords: CARD9, innate immunity, inflammation, apoptosis, autophagy, cardiovascular diseases


Citation styles

APA
Zhang, H., Wang, Y., Men, H., Zhou, W., Zhou, S., Liu, Q., Cai, L. (2022). CARD9 Regulation and its Role in Cardiovascular Diseases. International Journal of Biological Sciences, 18(3), 970-982. https://doi.org/10.7150/ijbs.65979.

ACS
Zhang, H.; Wang, Y.; Men, H.; Zhou, W.; Zhou, S.; Liu, Q.; Cai, L. CARD9 Regulation and its Role in Cardiovascular Diseases. Int. J. Biol. Sci. 2022, 18 (3), 970-982. DOI: 10.7150/ijbs.65979.

NLM
Zhang H, Wang Y, Men H, Zhou W, Zhou S, Liu Q, Cai L. CARD9 Regulation and its Role in Cardiovascular Diseases. Int J Biol Sci 2022; 18(3):970-982. doi:10.7150/ijbs.65979. https://www.ijbs.com/v18p0970.htm

CSE
Zhang H, Wang Y, Men H, Zhou W, Zhou S, Liu Q, Cai L. 2022. CARD9 Regulation and its Role in Cardiovascular Diseases. Int J Biol Sci. 18(3):970-982.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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