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Int J Biol Sci 2022; 18(4):1313-1327. doi:10.7150/ijbs.67892 This issue Cite

Review

Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma

Xiao-jie Liang1#, Xin-yu Song2#, Jia-lin Wu3#, Dan Liu2, Bing-yu Lin2, Hong-sheng Zhou1✉, Liang Wang4✉

1. Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
2. The First Clinical Medical College, Guangdong Medical University, Zhanjiang 524000, China.
3. Department of Interventional Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
4. Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
#The first three authors contributed equally to this work.

✉ Corresponding authors: Liang Wang, MD, Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Office Phone: +861058266633; Email: wangliangtrhoscom; Hong-sheng Zhou, MD, PhD, Department of Hematol More

Citation:
Liang Xj, Song Xy, Wu Jl, Liu D, Lin By, Zhou Hs, Wang L. Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma. Int J Biol Sci 2022; 18(4):1313-1327. doi:10.7150/ijbs.67892. https://www.ijbs.com/v18p1313.htm
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Abstract

Graphic abstract

As the most common subtype of non-Hodgkin's lymphoma, diffuse large B-cell lymphoma (DLBCL) is characterized by a huge degree of clinical and prognostic heterogeneity. Currently, there is an urgent need for highly specific and sensitive biomarkers to predict the therapeutic response of DLBCL and assess which patients can benefit from systemic chemotherapy to help develop more precise therapeutic regimens for DLBCL. Systems biology (holistic study of diseases) is more comprehensive in quantifying and identifying biomarkers, helps addressing major biological problems, and possesses high accuracy and sensitivity. In this article, we provide an overview of research advances in DLBCL prognostic biomarkers made using the multi-omics approach of genomics, transcriptomics, epigenetics, proteomics, metabonomics, radiomics, and the currently developing single-cell technologies.

Keywords: Diffuse large B cell lymphoma, Prognosis, Precision medicine, Systems biology, Biomarkers

Citation styles

APA
Liang, X.j., Song, X.y., Wu, J.l., Liu, D., Lin, B.y., Zhou, H.s., Wang, L. (2022). Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma. International Journal of Biological Sciences, 18(4), 1313-1327. https://doi.org/10.7150/ijbs.67892.

ACS
Liang, X.j.; Song, X.y.; Wu, J.l.; Liu, D.; Lin, B.y.; Zhou, H.s.; Wang, L. Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma. Int. J. Biol. Sci. 2022, 18 (4), 1313-1327. DOI: 10.7150/ijbs.67892.

NLM
Liang Xj, Song Xy, Wu Jl, Liu D, Lin By, Zhou Hs, Wang L. Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma. Int J Biol Sci 2022; 18(4):1313-1327. doi:10.7150/ijbs.67892. https://www.ijbs.com/v18p1313.htm

CSE
Liang Xj, Song Xy, Wu Jl, Liu D, Lin By, Zhou Hs, Wang L. 2022. Advances in Multi-Omics Study of Prognostic Biomarkers of Diffuse Large B-Cell Lymphoma. Int J Biol Sci. 18(4):1313-1327.

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