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Int J Biol Sci 2022; 18(8):3447-3457. doi:10.7150/ijbs.72244 This issue Cite

Review

Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy

Zhuang Liu1†, Mingming Xiao1†, Yaqi Mo2†, Han Wang1†, Yamei Han1, Xu Zhao1, Xue Yang1, Zhenxing Liu2, Bo Xu1,2✉

1. Department of Biochemistry and Molecular Biology, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China
2. Chongqing Key Laboratory of Intelligent Oncology for Breast Cancer, Chongqing University Cancer Hospital and Chongqing University School of Medicine, Chongqing 400030, China
†These authors have contributed equally to this work.

✉ Corresponding author: Bo Xu, MD, PhD. Chongqing University Cancer Hospital. xuboedu.cn; xubo731edu.cn

Citation:
Liu Z, Xiao M, Mo Y, Wang H, Han Y, Zhao X, Yang X, Liu Z, Xu B. Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy. Int J Biol Sci 2022; 18(8):3447-3457. doi:10.7150/ijbs.72244. https://www.ijbs.com/v18p3447.htm
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Abstract

Graphic abstract

Protein palmitoylation is an increasingly investigated form of post-translational lipid modification that affects protein localization, accumulation, secretion and function. Recently, emerging findings have revealed that protein palmitoylation is crucial for many tumor-related signaling pathways, such as EGFR, RAS, PD-1/PD-L1 signaling, affecting the occurrence, progression and therapeutic response of tumors. Protein palmitoylation and its modifying enzymes, including palmitoylases and depalmitoylases, are expected to be new targets for effective tumor treatment. Recognizing the significance of palmitoylation modification on protein stability, localization and downstream signal regulation, this review focuses on the regulatory roles of protein palmitoylation and its modifying enzymes in tumor cell signal transduction, aiming to bring new ideas for effective cancer prevention and treatment.

Keywords: Palmitoylation, Palmitoylase, Depalmitoylase, Signal transduction, DNA damage response

Citation styles

APA
Liu, Z., Xiao, M., Mo, Y., Wang, H., Han, Y., Zhao, X., Yang, X., Liu, Z., Xu, B. (2022). Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy. International Journal of Biological Sciences, 18(8), 3447-3457. https://doi.org/10.7150/ijbs.72244.

ACS
Liu, Z.; Xiao, M.; Mo, Y.; Wang, H.; Han, Y.; Zhao, X.; Yang, X.; Liu, Z.; Xu, B. Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy. Int. J. Biol. Sci. 2022, 18 (8), 3447-3457. DOI: 10.7150/ijbs.72244.

NLM
Liu Z, Xiao M, Mo Y, Wang H, Han Y, Zhao X, Yang X, Liu Z, Xu B. Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy. Int J Biol Sci 2022; 18(8):3447-3457. doi:10.7150/ijbs.72244. https://www.ijbs.com/v18p3447.htm

CSE
Liu Z, Xiao M, Mo Y, Wang H, Han Y, Zhao X, Yang X, Liu Z, Xu B. 2022. Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy. Int J Biol Sci. 18(8):3447-3457.

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