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Int J Biol Sci 2023; 19(1):167-182. doi:10.7150/ijbs.78321 This issue Cite

Review

Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers

Zeyi Lu#, yuanlei Chen#, Wenqin Luo, Lifeng Ding, Huan Wang, Yang Li, Bo wen Yang, Liangliang Ren, Qiming Zheng, Haiyun Xie, Ruyue Wang, Chenhao Yu, Yudong Lin, Zhenwei Zhou, Liqun Xia✉, Gonghui Li✉

Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
#These authors have contributed equally to this work and share first authorship.

✉ Corresponding authors: Gonghui Li, Department of Urology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. E-mail: 3193119edu.cn; Liqun Xia, Department of Urology, Sir Run Run Shaw Hospital, Zhejiang Universit More

Citation:
Lu Z, Chen y, Luo W, Ding L, Wang H, Li Y, Yang Bw, Ren L, Zheng Q, Xie H, Wang R, Yu C, Lin Y, Zhou Z, Xia L, Li G. Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers. Int J Biol Sci 2023; 19(1):167-182. doi:10.7150/ijbs.78321. https://www.ijbs.com/v19p0167.htm
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Abstract

Graphic abstract

Drug resistance presents a major obstacle in the treatment of genitourinary cancers. Exosomes as the medium of intercellular communication serve important biological functions and play essential roles in pathological processes, including drug response. Through the transfer of bioactive cargoes, exosomes can modulate drug resistance via multiple mechanisms. This review attempts to elucidate the mechanisms of exosomal cargoes with reference to tumor drug resistance, their role in genitourinary cancers, and their potential clinical applications as candidate biomarkers in liquid biopsy.

Keywords: exosome, genitourinary cancers, drug resistance

Citation styles

APA
Lu, Z., Chen, y., Luo, W., Ding, L., Wang, H., Li, Y., Yang, B.w., Ren, L., Zheng, Q., Xie, H., Wang, R., Yu, C., Lin, Y., Zhou, Z., Xia, L., Li, G. (2023). Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers. International Journal of Biological Sciences, 19(1), 167-182. https://doi.org/10.7150/ijbs.78321.

ACS
Lu, Z.; Chen, y.; Luo, W.; Ding, L.; Wang, H.; Li, Y.; Yang, B.w.; Ren, L.; Zheng, Q.; Xie, H.; Wang, R.; Yu, C.; Lin, Y.; Zhou, Z.; Xia, L.; Li, G. Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers. Int. J. Biol. Sci. 2023, 19 (1), 167-182. DOI: 10.7150/ijbs.78321.

NLM
Lu Z, Chen y, Luo W, Ding L, Wang H, Li Y, Yang Bw, Ren L, Zheng Q, Xie H, Wang R, Yu C, Lin Y, Zhou Z, Xia L, Li G. Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers. Int J Biol Sci 2023; 19(1):167-182. doi:10.7150/ijbs.78321. https://www.ijbs.com/v19p0167.htm

CSE
Lu Z, Chen y, Luo W, Ding L, Wang H, Li Y, Yang Bw, Ren L, Zheng Q, Xie H, Wang R, Yu C, Lin Y, Zhou Z, Xia L, Li G. 2023. Exosomes in Genitourinary Cancers: Emerging Mediators of Drug Resistance and Promising Biomarkers. Int J Biol Sci. 19(1):167-182.

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