AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis

Wang, Qi; Gao, Su; Shou, Yi; Jia, Yujie; Wei, Zhihao; Liu, Yuenan; Shi, Jian; Miao, Daojia; Miao, Qi; Zhao, Chuanyi; Liu, Chenchen; Yang, Hongmei; Xu, Tianbo; Zhang, Xiaoping

doi:10.7150/ijbs.79853

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International Journal of Medical Sciences

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Int J Biol Sci 2023; 19(4):1266-1283. doi:10.7150/ijbs.79853 This issue Cite

Research Paper

AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis

Qi Wang^1,2†, Su Gao^4,5†, Yi Shou^1,2†, Yujie Jia^7†, Zhihao Wei^1,2, Yuenan Liu^1,2, Jian Shi^1,2, Daojia Miao^1,2, Qi Miao^1,2, Chuanyi Zhao^1,2, Chenchen Liu^1,2, Hongmei Yang⁶, Tianbo Xu^1,2✉, Xiaoping Zhang^1,2,3✉

1. Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
2. Institute of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
3. Shenzhen Huazhong University of Science and Technology Research Institute, Shenzhen, China.
4. Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
5. Institute of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
6. Department of Pathogenic Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.
7. Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
†These authors have contributed equally to this work

Citation:

Wang Q, Gao S, Shou Y, Jia Y, Wei Z, Liu Y, Shi J, Miao D, Miao Q, Zhao C, Liu C, Yang H, Xu T, Zhang X. AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis. Int J Biol Sci 2023; 19(4):1266-1283. doi:10.7150/ijbs.79853. https://www.ijbs.com/v19p1266.htm

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Abstract

Renal cell carcinoma (RCC) is a serious threat to people's health due to its rapid progression, and patients easily develop resistance to targeted therapy. The absent in melanoma 2 (AIM2) is a receptor protein that has recently been proposed to play an important role in various diseases. In this study, AIM2 was identified as a new biomarker of RCC and promoted RCC progression and sunitinib resistance in an inflammasome-independent manner. Mechanistically, AIM2 promoted FOXO3a phosphorylation and proteasome degradation, thereby reducing its transcriptional effect on ACSL4 and inhibiting ferroptosis. In summary, AIM2 promoted RCC progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis, which could provide new ideas and therapeutic targets for RCC diagnosis and treatment.

Keywords: Renal cell carcinoma, Absent in melanoma2, Ferroptosis, Sunitinib resistance, ACSL4

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APA

Wang, Q., Gao, S., Shou, Y., Jia, Y., Wei, Z., Liu, Y., Shi, J., Miao, D., Miao, Q., Zhao, C., Liu, C., Yang, H., Xu, T., Zhang, X. (2023). AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis. International Journal of Biological Sciences, 19(4), 1266-1283. https://doi.org/10.7150/ijbs.79853.

ACS

Wang, Q.; Gao, S.; Shou, Y.; Jia, Y.; Wei, Z.; Liu, Y.; Shi, J.; Miao, D.; Miao, Q.; Zhao, C.; Liu, C.; Yang, H.; Xu, T.; Zhang, X. AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis. Int. J. Biol. Sci. 2023, 19 (4), 1266-1283. DOI: 10.7150/ijbs.79853.

NLM

CSE

Wang Q, Gao S, Shou Y, Jia Y, Wei Z, Liu Y, Shi J, Miao D, Miao Q, Zhao C, Liu C, Yang H, Xu T, Zhang X. 2023. AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis. Int J Biol Sci. 19(4):1266-1283.

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