ISSN: 1449-2288International Journal of Biological Sciences
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Int J Biol Sci 2023; 19(14):4442-4456. doi:10.7150/ijbs.83468 This issue Cite
Research Paper
Role of glycosphingolipid biosynthesis coregulators in malignant progression of thymoma
1. Department of Thoracic Surgery, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.
2. Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China.
3. School of Medicine, Stanford University, 450 Serra Mall, Stanford, CA 94305, USA.
†Xin Zhang, Bo Zeng, and Haoshuai Zhu made equal contributions to this article.
Citation:
Zhang X, Zeng B, Zhu H, Ma R, Yuan P, Chen Z, Su C, Liu Z, Yao X, Lawrence A, Liu Z, Zou J. Role of glycosphingolipid biosynthesis coregulators in malignant progression of thymoma. Int J Biol Sci 2023; 19(14):4442-4456. doi:10.7150/ijbs.83468. https://www.ijbs.com/v19p4442.htm
Other stylesAbstract
As the most common malignancy from mediastinum, the metabolic reprogramming of thymoma is important in its development. Nevertheless, the connection between the metabolic map and thymoma development is yet to be discovered. Thymoma was categorized into three subcategories by unsupervised clustering of molecular markers for metabolic pathway presentation in the TCGA dataset. Different genes and functions enriched were demonstrated through the utilization of metabolic Gene Ontology (GO) analysis. To identify the main contributors in the development of thymic malignancy, we utilized Gene Set Enrichment Analysis (GSEA), Gene Set Variation Analysis (GSVA), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The prognosis of thymoma was evaluated by screening the essential pathways and genes using GSVA scores and machine learning classifiers. Furthermore, we integrated the transcriptomics findings with spectrum metabolomics investigation, detected through LC-MS/MS, in order to establish the essential controller network of metabolic reprogramming during thymoma progression. The thymoma prognosis is related to glycosphingolipid biosynthesis-lacto and neolacto series pathway, of what high B3GNT5 indicate poor survival. The investigation revealed that glycosphingolipid charts have a significant impact on metabolic dysfunction and could potentially serve as crucial targets in the clinical advancement of metabolic therapy.
Keywords: Mass spectrometry analysis, Thymoma, Metabolic reprogramming, Glycosphingolipid
Citation styles
APA
Zhang, X., Zeng, B., Zhu, H., Ma, R., Yuan, P., Chen, Z., Su, C., Liu, Z., Yao, X., Lawrence, A., Liu, Z., Zou, J. (2023). Role of glycosphingolipid biosynthesis coregulators in malignant progression of thymoma. International Journal of Biological Sciences, 19(14), 4442-4456. https://doi.org/10.7150/ijbs.83468.
ACS
Zhang, X.; Zeng, B.; Zhu, H.; Ma, R.; Yuan, P.; Chen, Z.; Su, C.; Liu, Z.; Yao, X.; Lawrence, A.; Liu, Z.; Zou, J. Role of glycosphingolipid biosynthesis coregulators in malignant progression of thymoma. Int. J. Biol. Sci. 2023, 19 (14), 4442-4456. DOI: 10.7150/ijbs.83468.
NLM
Zhang X, Zeng B, Zhu H, Ma R, Yuan P, Chen Z, Su C, Liu Z, Yao X, Lawrence A, Liu Z, Zou J. Role of glycosphingolipid biosynthesis coregulators in malignant progression of thymoma. Int J Biol Sci 2023; 19(14):4442-4456. doi:10.7150/ijbs.83468. https://www.ijbs.com/v19p4442.htm
CSE
Zhang X, Zeng B, Zhu H, Ma R, Yuan P, Chen Z, Su C, Liu Z, Yao X, Lawrence A, Liu Z, Zou J. 2023. Role of glycosphingolipid biosynthesis coregulators in malignant progression of thymoma. Int J Biol Sci. 19(14):4442-4456.
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