ISSN: 1449-2288International Journal of Biological Sciences
Global reach, higher impact
Int J Biol Sci 2023; 19(16):5089-5103. doi:10.7150/ijbs.87334 This issue Cite
Review
The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics
1. Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
2. Department of Emergency, Taihe Hospital, Shiyan, China.
# These authors contributed equally to this work.
Citation:
Song C, Zhang J, Xu C, Gao M, Li N, Geng Q. The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics. Int J Biol Sci 2023; 19(16):5089-5103. doi:10.7150/ijbs.87334. https://www.ijbs.com/v19p5089.htm
Other stylesAbstract
As a multi-substrate transmembrane protease, γ-secretase exists widely in various cells. It controls multiple important cellular activities through substrate cleavage. γ-secretase inhibitors (GSIs) play a role in cancer inhibition by blocking Notch cleavage, and are considered as potential therapeutic strategies for cancer. Currently, GSIs have encouraging performance in preclinical models, yet this success does not translate well in clinical trials. In recent years, a number of breakthrough discoveries have shown us the promise of targeting γ-secretase for the treatment of cancer. Here, we integrate a large amount of data from γ-secretase and its inhibitors and cancer in nearly 30 years, comb and discuss the close connection between γ-secretase and cancer, as well as the potential and problems of current GSIs in cancer treatment. We analyze the possible reasons for the failure performance of current GSIs in clinical trials, and make recommendations for future research areas.
Keywords: γ-secretase, γ-secretase inhibitors (GSIs), cancer
Citation styles
APA
Song, C., Zhang, J., Xu, C., Gao, M., Li, N., Geng, Q. (2023). The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics. International Journal of Biological Sciences, 19(16), 5089-5103. https://doi.org/10.7150/ijbs.87334.
ACS
Song, C.; Zhang, J.; Xu, C.; Gao, M.; Li, N.; Geng, Q. The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics. Int. J. Biol. Sci. 2023, 19 (16), 5089-5103. DOI: 10.7150/ijbs.87334.
NLM
Song C, Zhang J, Xu C, Gao M, Li N, Geng Q. The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics. Int J Biol Sci 2023; 19(16):5089-5103. doi:10.7150/ijbs.87334. https://www.ijbs.com/v19p5089.htm
CSE
Song C, Zhang J, Xu C, Gao M, Li N, Geng Q. 2023. The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics. Int J Biol Sci. 19(16):5089-5103.
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.