1. Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China. 2. Department of Pathology, Xiangya Hospital of Central South University, Changsha, Hunan, China. 3. Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, China.
Zhan Y, Wang W, Wang H, Xu Y, Zhang Y, Ning Y, Zheng H, Luo J, Yang Y, Zang H, Zhou M, Fan S. G3BP1 Interact with JAK2 mRNA to Promote the Malignant Progression of Nasopharyngeal Carcinoma via Activating JAK2/STAT3 Signaling Pathway. Int J Biol Sci 2024; 20(1):94-112. doi:10.7150/ijbs.85341. https://www.ijbs.com/v20p0094.htm
Ras-GTPase-activating protein (GAP)-binding protein 1 (G3BP1) is an RNA-binding protein implicated in various malignancies. However, its role in nasopharyngeal carcinoma (NPC) remains elusive. This study elucidates the potential regulation mechanisms of G3BP1 and its significance in NPC advancement. Through knockdown and overexpression approaches, we validate G3BP1's oncogenic role by promoting proliferation, migration, and invasion in vitro and in vivo. Moreover, G3BP1 emerges as a key regulator of the JAK2/STAT3 signaling pathway, augmenting JAK2 expression via mRNA binding. Notably, epigallocatechin gallate (EGCG), a green tea-derived antioxidant, counteracts G3BP1-mediated pathway activation. Clinical analysis reveals heightened G3BP1, JAK2, and p-STAT3 as powerful prognostic markers, with G3BP1's expression standing as an independent indicator of poorer outcomes for NPC patients. In conclusion, the study unveils the oncogenic prowess of G3BP1, its orchestration of the JAK2/STAT3 signaling pathway, and its pivotal role in NPC progression.
Zhan, Y., Wang, W., Wang, H., Xu, Y., Zhang, Y., Ning, Y., Zheng, H., Luo, J., Yang, Y., Zang, H., Zhou, M., Fan, S. (2024). G3BP1 Interact with JAK2 mRNA to Promote the Malignant Progression of Nasopharyngeal Carcinoma via Activating JAK2/STAT3 Signaling Pathway. International Journal of Biological Sciences, 20(1), 94-112. https://doi.org/10.7150/ijbs.85341.
ACS
Zhan, Y.; Wang, W.; Wang, H.; Xu, Y.; Zhang, Y.; Ning, Y.; Zheng, H.; Luo, J.; Yang, Y.; Zang, H.; Zhou, M.; Fan, S. G3BP1 Interact with JAK2 mRNA to Promote the Malignant Progression of Nasopharyngeal Carcinoma via Activating JAK2/STAT3 Signaling Pathway. Int. J. Biol. Sci. 2024, 20 (1), 94-112. DOI: 10.7150/ijbs.85341.
NLM
Zhan Y, Wang W, Wang H, Xu Y, Zhang Y, Ning Y, Zheng H, Luo J, Yang Y, Zang H, Zhou M, Fan S. G3BP1 Interact with JAK2 mRNA to Promote the Malignant Progression of Nasopharyngeal Carcinoma via Activating JAK2/STAT3 Signaling Pathway. Int J Biol Sci 2024; 20(1):94-112. doi:10.7150/ijbs.85341. https://www.ijbs.com/v20p0094.htm
CSE
Zhan Y, Wang W, Wang H, Xu Y, Zhang Y, Ning Y, Zheng H, Luo J, Yang Y, Zang H, Zhou M, Fan S. 2024. G3BP1 Interact with JAK2 mRNA to Promote the Malignant Progression of Nasopharyngeal Carcinoma via Activating JAK2/STAT3 Signaling Pathway. Int J Biol Sci. 20(1):94-112.
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