Int J Biol Sci
2020; 16(11):1929-1940.
doi:10.7150/ijbs.45231 This issueCite
Review
Function and evolution of RNA N6-methyladenosine modification
Zhi-Man Zhu*, Fu-Chun Huo*, Dong-Sheng Pei✉
Department of Pathology, Xuzhou Medical University, Xuzhou 221004, China *These authors contributed equally to this work.
✉ Corresponding author: Dong-Sheng Pei, Address: 84 West Huaihai Road, Xuzhou, Jiangsu, P. R. China. E-mail: dspeiedu.cn
Citation:
Zhu ZM, Huo FC, Pei DS. Function and evolution of RNA N6-methyladenosine modification. Int J Biol Sci 2020; 16(11):1929-1940. doi:10.7150/ijbs.45231. https://www.ijbs.com/v16p1929.htm
N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers), removed by the demethylases FTO and ALKBH5 (Erasers) and recognized by m6A binding proteins, such as YT521-B homology YTH domain-containing proteins (Readers). Accumulating evidence shows that m6A RNA methylation participates in almost all aspects of RNA processing, implying an association with important bioprocesses. In this review, we mainly summarize and discuss the functional relevance and importance of m6A modification in cellular processes.
Keywords: m6A modification, methylation, RNA, function
Citation styles
APA
Zhu, Z.M., Huo, F.C., Pei, D.S. (2020). Function and evolution of RNA N6-methyladenosine modification. International Journal of Biological Sciences, 16(11), 1929-1940. https://doi.org/10.7150/ijbs.45231.
ACS
Zhu, Z.M.; Huo, F.C.; Pei, D.S. Function and evolution of RNA N6-methyladenosine modification. Int. J. Biol. Sci. 2020, 16 (11), 1929-1940. DOI: 10.7150/ijbs.45231.
NLM
Zhu ZM, Huo FC, Pei DS. Function and evolution of RNA N6-methyladenosine modification. Int J Biol Sci 2020; 16(11):1929-1940. doi:10.7150/ijbs.45231. https://www.ijbs.com/v16p1929.htm
CSE
Zhu ZM, Huo FC, Pei DS. 2020. Function and evolution of RNA N6-methyladenosine modification. Int J Biol Sci. 16(11):1929-1940.
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