Function and evolution of RNA N6-methyladenosine modification

Zhu, Zhi-Man; Huo, Fu-Chun; Pei, Dong-Sheng

doi:10.7150/ijbs.45231

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Int J Biol Sci 2020; 16(11):1929-1940. doi:10.7150/ijbs.45231 This issue Cite

Review

Function and evolution of RNA N6-methyladenosine modification

Zhi-Man Zhu^*, Fu-Chun Huo^*, Dong-Sheng Pei^✉

Department of Pathology, Xuzhou Medical University, Xuzhou 221004, China
*These authors contributed equally to this work.

Citation:

Zhu ZM, Huo FC, Pei DS. Function and evolution of RNA N6-methyladenosine modification. Int J Biol Sci 2020; 16(11):1929-1940. doi:10.7150/ijbs.45231. https://www.ijbs.com/v16p1929.htm

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Abstract

N6-methyladenosine (m⁶A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m⁶A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers), removed by the demethylases FTO and ALKBH5 (Erasers) and recognized by m⁶A binding proteins, such as YT521-B homology YTH domain-containing proteins (Readers). Accumulating evidence shows that m⁶A RNA methylation participates in almost all aspects of RNA processing, implying an association with important bioprocesses. In this review, we mainly summarize and discuss the functional relevance and importance of m⁶A modification in cellular processes.

Keywords: m⁶A modification, methylation, RNA, function

Citation styles

APA

Zhu, Z.M., Huo, F.C., Pei, D.S. (2020). Function and evolution of RNA N6-methyladenosine modification. International Journal of Biological Sciences, 16(11), 1929-1940. https://doi.org/10.7150/ijbs.45231.

ACS

Zhu, Z.M.; Huo, F.C.; Pei, D.S. Function and evolution of RNA N6-methyladenosine modification. Int. J. Biol. Sci. 2020, 16 (11), 1929-1940. DOI: 10.7150/ijbs.45231.

NLM

Zhu ZM, Huo FC, Pei DS. Function and evolution of RNA N6-methyladenosine modification. Int J Biol Sci 2020; 16(11):1929-1940. doi:10.7150/ijbs.45231. https://www.ijbs.com/v16p1929.htm

CSE

Zhu ZM, Huo FC, Pei DS. 2020. Function and evolution of RNA N6-methyladenosine modification. Int J Biol Sci. 16(11):1929-1940.

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