Volume 22, Issue 15

Volume 22 (15); 2026

Research Papers

Combined Point Mutation in a Single Allele of the TP53 Gene Potentiates the Oncogenic and Transcriptional Properties of TP53 in Lung Cancer Sicheng Bian, Huiqin Bian, Hiroaki Koyama, Dmytro Kompaniiets, William Tse, Mithun V Shah, Aref Al-Kali, Alexander Miron, Bin Liu, Shujun Liu Int. J. Biol. Sci. 2026; 22(15): 8139-8157. doi:10.7150/ijbs.131687 Full text PDF

Actin cortex formation is required for integrin clustering but not activation during leukocyte adhesion Doulathunnisa Ahamed Younis, Raphael Serna, Wei Liu, Beiyan Zhou, Anthony T. Vella, Liang Hu, Yunfeng Chen, Ji Yu, Emanuela M. Bruscia, Zhichao Fan Int. J. Biol. Sci. 2026; 22(15): 8158-8175. doi:10.7150/ijbs.137102 Full text PDF

Histone acetyltransferases and deacetylase 6 (HDAC6) Promotes Hepatic Stellate Cell Activation and Liver Fibrosis Ji Hyun Lee, Ann-Yae Na, Ji Hye Kim, Tae Hyun Park, Ji Hye Yang, Joo Yong Lee, Chang Yeob Han, Sohi Kang, IL Je Cho, Sangkyu Lee, Sung Hwan Ki Int. J. Biol. Sci. 2026; 22(15): 8176-8192. doi:10.7150/ijbs.137447 Full text PDF

LDHA Lactylation Drives Malignant Progression of Oral Squamous Cell Carcinoma via a Positive Feedback Loop with Lactate Fan Song, Chen Hou, Yingzhao Huang, Hongshi Cai, Jianfeng Liang, Yaoqi Jiang, Qiong Xu, Jinsong Hou Int. J. Biol. Sci. 2026; 22(15): 8193-8209. doi:10.7150/ijbs.136949 Full text PDF

Targeting NCAPG with Arundanine Suppresses Neutrophil/NET-Mediated Immune Evasion and Enhances CD8⁺ T Cell Function in Lung Squamous Cell Carcinoma Xuyu Gu, Dongning Lu, Ming Deng, Tao Ge, Kaiqi Jin, Xinnan Xu, Li Xu Int. J. Biol. Sci. 2026; 22(15): 8211-8229. doi:10.7150/ijbs.134668 Full text PDF

CST1 Regulates ER-Mitochondrial Mg²⁺ Balance via MAGT1 to Promote Breast Cancer Metabolism and Growth Wenqiang Gan, Min Zheng, Li Liu, Jingwen Liao, Yu Zhu, Xiaochen Hou, Qunshan Liu, Hui Li, Jing Yao, Dewei Jiang, Ceshi Chen Int. J. Biol. Sci. 2026; 22(15): 8230-8250. doi:10.7150/ijbs.136015 Full text PDF

Exon-6 truncated p53 Suppresses Innate Immune Responses to Facilitate Immune Evasion in Bladder Cancer Chi Zhang, Wenjie Wei, Senming Cao, Zhi Li, Chuang Wang, Wen Tao, Yuhao Dong, Chunyu Liu, Shun Wu, Shuo Tian, Qingbo Huang, Baojun Wang, Hongzhao Li, Xin Ma, Xu Zhang, Yan Huang Int. J. Biol. Sci. 2026; 22(15): 8251-8270. doi:10.7150/ijbs.131491 Full text PDF

PAK1 Promotes Gluconeogenesis Via the ACSS2/KAT2A/PCK1 Complex to Attenuate Steatotic Liver Ischemia-Reperfusion Injury Fengqiang Gao, Ye Tao, Zijian Lou, Jinjian Li, Libin Dong, Yuhang Huang, Xiao Tang, Hanzhi Xu, Zhoucheng Wang, Shusen Zheng, Lixing Zhan, Xinyu Yang, Shengjun Xu, Kai Wang, Xiao Xu Int. J. Biol. Sci. 2026; 22(15): 8271-8285. doi:10.7150/ijbs.132770 Full text PDF

FKBP9 Drives Hepatocellular Carcinoma EMT by Regulating SEPT6 Transcription and Stability to Activate TGF-β Signaling Yu Zhang, Rixin Su, Jie Zou, Wangyang Sun, Banglong Song, Long Liu, Shuanghu Yuan Int. J. Biol. Sci. 2026; 22(15): 8286-8301. doi:10.7150/ijbs.134156 Full text PDF

Citrullination of VDAC3 by PAD2 restricts mitochondrial metabolism and suppresses macrophage reprogramming in sepsis Liujiazi Shao, Chao Quan, Tao Dong, Yuchen Chen, Xin Yu, Wenlu Ouyang, Dan Qi, Jeffrey Chu, Erxi Wu, Zequan Yang, Jianjie Ma, Yongqing Li Int. J. Biol. Sci. 2026; 22(15): 8302-8317. doi:10.7150/ijbs.126368 Full text PDF

OLFM4 promotes intrahepatic cholangiocarcinoma progression through a PKM2-glycolysis-histone lactylation feedback loop Shuochen Liu, Kai Cao, Changan Chen, Xiao Xu, Jijun Shan, Chang Li, Ruixiang Chen, Yananlan Chen, Jiang Chang, Wangjie Jiang, Yaodong Zhang, Dong Wang, Changxian Li, Xiangcheng Li Int. J. Biol. Sci. 2026; 22(15): 8333-8347. doi:10.7150/ijbs.135505 Full text PDF

RAB7A-enriched extracellular vesicles drive early-metastasis and immune evasion in triple-negative breast cancer Hanyi Zhong, Han Wang, Weiqi Gao, Ziling Zhou, Shoutang Wang, Ou Huang, Renhong Huang, Zheng Wang, Kunwei Shen Int. J. Biol. Sci. 2026; 22(15): 8348-8363. doi:10.7150/ijbs.138205 Full text PDF

Young plasma-derived exosomes deliver YOD1 to induce M2 polarization and ameliorate osteoporosis via mTOR signaling pathways Jiahao Wang, Xiaokang Zhang, Siteng Li, Qi Zhang, Jiheng Xiao, Chengbin Huang, Jianpeng Chen, Yang Luo, Zeming Shan, Ziping Chen, Ling Wang, Yingze Zhang Int. J. Biol. Sci. 2026; 22(15): 8364-8389. doi:10.7150/ijbs.138620 Full text PDF

KAT6A-Mutant iPSC-Derived Cortical Neurons Display Precocious Maturation, Dysregulated Electrophysiology, and Altered Morphology Naama Wiesel-Motiuk, Ashwani Choudhary, Yara Hussein, Utkarsh Tripathi, Wote Amelo Rike, Aviram Shemen, Ritu Nayak, Souvik Chakraborty, Omveer Sharma, Tatiana Rabinski, Michal Stark, Karin Weiss, Gad D. Vatine, Shani Stern, Yehuda G. Assaraf Int. J. Biol. Sci. 2026; 22(15): 8448-8475. doi:10.7150/ijbs.134210 Full text PDF

Radiotherapy Reprograms CCR8⁺ Regulatory T Cells via REL-NF-κB to Enforce Spatial Immune Exclusion in Hepatocellular Carcinoma Huanliang Chen, Shuxuan Wang, Bufu Tang, Yanyan Lin, Pan Zhou, Jiaoyang Yang, Qian-Qian Zhao, Zhao-Chong Zeng Int. J. Biol. Sci. 2026; 22(15): 8476-8491. doi:10.7150/ijbs.136364 Full text PDF

UPF1-mediated mRNA decay promotes melanoma tumorigenesis through miR-101-3p-dependent destabilization of NANOS1 Suman Lee, Jae-Won Yoon, Dayeon Woo, Hyunho Cha, Seungwon Jung, Je-Min Choi, Jungwook Hwang Int. J. Biol. Sci. 2026; 22(15): 8492-8510. doi:10.7150/ijbs.134804 Full text PDF

Extracellular Vesicles from Human Induced Pluripotent Stem Cells Reduce Lung Ischemia-Reperfusion Injury via Cytoprotective Mechanisms in both 2D Cultures and a Human Airway Organoid Model Rosaria Tinnirello, Maria Chiara Iachini, Maura Cimino, Noemi Elia, Margot Lo Pinto, Simone Dario Scilabra, Gioacchin Iannolo, Giovanni Zito, Roberta Vazzana, Nicola Cuscino, Matteo Bulati, Tuğba Dursun Usal, Federica Cosentino, Antonio D'amore, Federica Guffanti, Giovanna Damia, Vincenza Dolo, Massimo Pinzani, Pier Giulio Conaldi, Alessandro Bertani, Lorenzo Rosso, Lorenza Lazzari, Vitale Miceli Int. J. Biol. Sci. 2026; 22(15): 8571-8590. doi:10.7150/ijbs.134686 Full text PDF

GZMK⁺CD8⁺ T Cells Induce Acinar Cell Senescence and Salivary Secretion Impairment in Sjögren's Syndrome via Mitochondrial Dysfunction and TMEM16A Chloride Channel Disruption Maosheng Chai, Yufei Xie, Xin Cong, Chong Ding, Pan Wei, Peiru Zhou, Binbin Li, Hong Hua Int. J. Biol. Sci. 2026; 22(15): 8591-8613. doi:10.7150/ijbs.134478 Full text PDF

PEGylated nicotinamide mononucleotide targeted ferroptosis in acute kidney injury by suppressing FAR1 palmitoylation in an ACAA1-dependent manner Yang Yue, Changdong Zhou, Qingyu Li, Xiaochang Zhang, Hongjun Lin, Ming Niu, Aihong Zhang, Shuiqin Gong, Lijing Yang, Yuke Cui, Hong Chen, Xiaodan Cheng, Jiangbo Li, Qi He, Chenhui Wang, Jian Li, Wen Yang, Jian Bai, Jingqi Shi, Yanze Li, Xing Qin, Xiangmei Chen, Liang Guo, Shengqi Wang Int. J. Biol. Sci. 2026; 22(15): 8614-8635. doi:10.7150/ijbs.132234 Full text PDF

HMGA2 Stabilizes hnRNPK to Drive YAP-Dependent Liver Metastasis in Pancreatic Cancer Yu Xie, Hexing Hang, Haobai Liu, Nannan Wang, Chengzhi Wang, Yifei Yang, Lei Fang, Yudong Qiu, Hao Cheng Int. J. Biol. Sci. 2026; 22(15): 8636-8652. doi:10.7150/ijbs.133139 Full text PDF

CYLD: A Key Factor and Novel Predictive Biomarker of Cross-Resistance to Chemotherapy and Radiotherapy in Oral Squamous Cell Carcinoma Kou Yonemaru, Naoki Suenaga, Takeshi Masuda, Ryusho Kariya, Yuki Seki, Ryoji Yoshida, Hideki Nakayama, Yoshikazu Kuwahara, Fumihiro Nishimura, Kazutaka Oda, Jian-Dong Li, Hirofumi Jono Int. J. Biol. Sci. 2026; 22(15): 8653-8667. doi:10.7150/ijbs.138201 Full text PDF

Sanguinarine Induces Pyroptosis via the Hippo Signaling Pathway and Remodels the Tumor Immune Microenvironment in Lung Adenocarcinoma Jia Yang, Lanfang Li, Yunjian Pan, Wulei Hou, Xiaoyan Wang, Zhengda Li, Wenjie Wang, Yihua Sun, Ping Xu, Lifang Wang, Ying Lu, Zhongqi Wang, Zhenhui Lu, Zuoyun Wang Int. J. Biol. Sci. 2026; 22(15): 8668-8684. doi:10.7150/ijbs.139061 Full text PDF

Hypoxia Reprograms a Ciliary Scaffold into a Metabolic-Epigenetic Trafficking Hub via a Succinate-Driven DNMT3L-ASXL2 Axis Jun Yin, Zhifeng Zhong, Mengjie Zhang, Debao Li, Aiping Wang, Qianying Huang, Qinghua Zhang, Bing Ni, Wei He Int. J. Biol. Sci. 2026; 22(15): 8707-8738. doi:10.7150/ijbs.137355 Full text PDF

ECM stiffness inhibits ferroptosis to promote HCC progression via the FOXA1-CDON-HMGB1/p53 pathway Qianben Song, Xilin Ye, Xin Mao, Lumiao Zhang, Mengjia Jing, Yu Fu, Wei Yan Int. J. Biol. Sci. 2026; 22(15): 8740-8764. doi:10.7150/ijbs.129038 Full text PDF

Reviews

Cross-cutting circuits in heart failure with preserved ejection fraction: Integrating adipokine biology, mechanotransduction, and precision targeting KaiJian Zhang, Hui Li, Wei Wen, BuChun Zhang Int. J. Biol. Sci. 2026; 22(15): 8318-8332. doi:10.7150/ijbs.137328 Full text PDF

Extracellular Mitochondrial Components as Emerging Biomarkers and Therapeutic Targets in Human Diseases Kuan-Hao Tsui, Emmanuel Naveen Raj, Andy P. Tsai, Boyang Wang, Chen-Yueh Wen, Chia-Jung Li Int. J. Biol. Sci. 2026; 22(15): 8390-8407. doi:10.7150/ijbs.140360 Full text PDF

Metabolic Barriers to Cancer Immunotherapy: Multiscale Mechanisms from Organelle Dysfunction to Organ-Specific Constraints Zichen Gui, Xiaoyin Yuan, Xiaoping Chen, Qibo Huang, Bixiang Zhang, Junnan Liang Int. J. Biol. Sci. 2026; 22(15): 8408-8447. doi:10.7150/ijbs.137618 Full text PDF

CHK1 and CHK2 as Context-Dependent Rheostats of Genotoxic Stress: Implications for Cell Fate and Tumor Immunity Jinjia Yang, Zilin Liu, Yunzhou Chen, Yanling Feng, Yilun Liu, Huiyue Zheng, Yiran Zhao, Hongbo Fang, Yuting Chen, Lin Yuan, Ming Yang, Yiming Mu, Ning Bai, Ying Zhang, Liang Wang, Xiangxuan Zhao, Liu Cao, Xiaoman Li Int. J. Biol. Sci. 2026; 22(15): 8511-8531. doi:10.7150/ijbs.139580 Full text PDF

Spatiotemporal Immune-Fibroblast Crosstalk in Pulmonary Fibrosis: From Failed Repair to Fibrotic Niche Formation Simeng Lu, Weijia Zhang, Xiaoming Zhao, Chao Feng, Wangwang Chen, Yufang Shi, Jiankai Fang Int. J. Biol. Sci. 2026; 22(15): 8532-8570. doi:10.7150/ijbs.137072 Full text PDF

Orchestrating Physiological Homeostasis: The Spatial and Cellular Heterogeneity of Tryptophan Transport and Metabolism Xiaofeng Zhu, Yuling Zhang, Songlin Zhang, Sitong Chen, Yulong Yin, Xiongzhuo Tang Int. J. Biol. Sci. 2026; 22(15): 8689-8706. doi:10.7150/ijbs.139760 Full text PDF

Commentary

Extracellular vesicles orchestrate immune suppression and immune exclusion in cancer Seung-Jae Lee, Jaehoon Bae, Seong-Min Hong, Ji Young Hwang Int. J. Biol. Sci. 2026; 22(15): 8685-8688. doi:10.7150/ijbs.141013 Full text PDF