◂ Last issue Archive   

Volume 22 (15); 2026

Research Papers

Graphic abstract

Combined Point Mutation in a Single Allele of the TP53 Gene Potentiates the Oncogenic and Transcriptional Properties of TP53 in Lung Cancer Sicheng Bian, Huiqin Bian, Hiroaki Koyama, Dmytro Kompaniiets, William Tse, Mithun V Shah, Aref Al-Kali, Alexander Miron, Bin Liu, Shujun Liu Int. J. Biol. Sci. 2026; 22(15): 8139-8157. doi:10.7150/ijbs.131687 Full text PDF

Graphic abstract

Actin cortex formation is required for integrin clustering but not activation during leukocyte adhesion Doulathunnisa Ahamed Younis, Raphael Serna, Wei Liu, Beiyan Zhou, Anthony T. Vella, Liang Hu, Yunfeng Chen, Ji Yu, Emanuela M. Bruscia, Zhichao Fan Int. J. Biol. Sci. 2026; 22(15): 8158-8175. doi:10.7150/ijbs.137102 Full text PDF

Graphic abstract

Histone acetyltransferases and deacetylase 6 (HDAC6) Promotes Hepatic Stellate Cell Activation and Liver Fibrosis Ji Hyun Lee, Ann-Yae Na, Ji Hye Kim, Tae Hyun Park, Ji Hye Yang, Joo Yong Lee, Chang Yeob Han, Sohi Kang, IL Je Cho, Sangkyu Lee, Sung Hwan Ki Int. J. Biol. Sci. 2026; 22(15): 8176-8192. doi:10.7150/ijbs.137447 Full text PDF

Graphic abstract

LDHA Lactylation Drives Malignant Progression of Oral Squamous Cell Carcinoma via a Positive Feedback Loop with Lactate Fan Song, Chen Hou, Yingzhao Huang, Hongshi Cai, Jianfeng Liang, Yaoqi Jiang, Qiong Xu, Jinsong Hou Int. J. Biol. Sci. 2026; 22(15): 8193-8209. doi:10.7150/ijbs.136949 Full text PDF

Graphic abstract

Targeting NCAPG with Arundanine Suppresses Neutrophil/NET-Mediated Immune Evasion and Enhances CD8+ T Cell Function in Lung Squamous Cell Carcinoma Xuyu Gu, Dongning Lu, Ming Deng, Tao Ge, Kaiqi Jin, Xinnan Xu, Li Xu Int. J. Biol. Sci. 2026; 22(15): 8211-8229. doi:10.7150/ijbs.134668 Full text PDF

Graphic abstract

CST1 Regulates ER-Mitochondrial Mg²⁺ Balance via MAGT1 to Promote Breast Cancer Metabolism and Growth Wenqiang Gan, Min Zheng, Li Liu, Jingwen Liao, Yu Zhu, Xiaochen Hou, Qunshan Liu, Hui Li, Jing Yao, Dewei Jiang, Ceshi Chen Int. J. Biol. Sci. 2026; 22(15): 8230-8250. doi:10.7150/ijbs.136015 Full text PDF

Graphic abstract

Exon-6 truncated p53 Suppresses Innate Immune Responses to Facilitate Immune Evasion in Bladder Cancer Chi Zhang, Wenjie Wei, Senming Cao, Zhi Li, Chuang Wang, Wen Tao, Yuhao Dong, Chunyu Liu, Shun Wu, Shuo Tian, Qingbo Huang, Baojun Wang, Hongzhao Li, Xin Ma, Xu Zhang, Yan Huang Int. J. Biol. Sci. 2026; 22(15): 8251-8270. doi:10.7150/ijbs.131491 Full text PDF

Graphic abstract

PAK1 Promotes Gluconeogenesis Via the ACSS2/KAT2A/PCK1 Complex to Attenuate Steatotic Liver Ischemia-Reperfusion Injury Fengqiang Gao, Ye Tao, Zijian Lou, Jinjian Li, Libin Dong, Yuhang Huang, Xiao Tang, Hanzhi Xu, Zhoucheng Wang, Shusen Zheng, Lixing Zhan, Xinyu Yang, Shengjun Xu, Kai Wang, Xiao Xu Int. J. Biol. Sci. 2026; 22(15): 8271-8285. doi:10.7150/ijbs.132770 Full text PDF

Graphic abstract

FKBP9 Drives Hepatocellular Carcinoma EMT by Regulating SEPT6 Transcription and Stability to Activate TGF-β Signaling Yu Zhang, Rixin Su, Jie Zou, Wangyang Sun, Banglong Song, Long Liu, Shuanghu Yuan Int. J. Biol. Sci. 2026; 22(15): 8286-8301. doi:10.7150/ijbs.134156 Full text PDF

Graphic abstract

Citrullination of VDAC3 by PAD2 restricts mitochondrial metabolism and suppresses macrophage reprogramming in sepsis Liujiazi Shao, Chao Quan, Tao Dong, Yuchen Chen, Xin Yu, Wenlu Ouyang, Dan Qi, Jeffrey Chu, Erxi Wu, Zequan Yang, Jianjie Ma, Yongqing Li Int. J. Biol. Sci. 2026; 22(15): 8302-8317. doi:10.7150/ijbs.126368 Full text PDF

Graphic abstract

OLFM4 promotes intrahepatic cholangiocarcinoma progression through a PKM2-glycolysis-histone lactylation feedback loop Shuochen Liu, Kai Cao, Changan Chen, Xiao Xu, Jijun Shan, Chang Li, Ruixiang Chen, Yananlan Chen, Jiang Chang, Wangjie Jiang, Yaodong Zhang, Dong Wang, Changxian Li, Xiangcheng Li Int. J. Biol. Sci. 2026; 22(15): 8333-8347. doi:10.7150/ijbs.135505 Full text PDF

Graphic abstract

RAB7A-enriched extracellular vesicles drive early-metastasis and immune evasion in triple-negative breast cancer Hanyi Zhong, Han Wang, Weiqi Gao, Ziling Zhou, Shoutang Wang, Ou Huang, Renhong Huang, Zheng Wang, Kunwei Shen Int. J. Biol. Sci. 2026; 22(15): 8348-8363. doi:10.7150/ijbs.138205 Full text PDF

Graphic abstract

Young plasma-derived exosomes deliver YOD1 to induce M2 polarization and ameliorate osteoporosis via mTOR signaling pathways Jiahao Wang, Xiaokang Zhang, Siteng Li, Qi Zhang, Jiheng Xiao, Chengbin Huang, Jianpeng Chen, Yang Luo, Zeming Shan, Ziping Chen, Ling Wang, Yingze Zhang Int. J. Biol. Sci. 2026; 22(15): 8364-8389. doi:10.7150/ijbs.138620 Full text PDF

Reviews

Graphic abstract

Cross-cutting circuits in heart failure with preserved ejection fraction: Integrating adipokine biology, mechanotransduction, and precision targeting KaiJian Zhang, Hui Li, Wei Wen, BuChun Zhang Int. J. Biol. Sci. 2026; 22(15): 8318-8332. doi:10.7150/ijbs.137328 Full text PDF

Graphic abstract

Extracellular Mitochondrial Components as Emerging Biomarkers and Therapeutic Targets in Human Diseases Kuan-Hao Tsui, Emmanuel Naveen Raj, Andy P. Tsai, Boyang Wang, Chen-Yueh Wen, Chia-Jung Li Int. J. Biol. Sci. 2026; 22(15): 8390-8407. doi:10.7150/ijbs.140360 Full text PDF

Graphic abstract

Metabolic Barriers to Cancer Immunotherapy: Multiscale Mechanisms from Organelle Dysfunction to Organ-Specific Constraints Zichen Gui, Xiaoyin Yuan, Xiaoping Chen, Qibo Huang, Bixiang Zhang, Junnan Liang Int. J. Biol. Sci. 2026; 22(15): 8408-8447. doi:10.7150/ijbs.137618 Full text PDF

Popup Image

©2026 Ivyspring International Publisher. All rights reserved.
Open access content is subject to applicable licences. By accessing or using this platform, you agree to our Terms of Use.