Volume 22, Issue 13

Volume 22 (13); 2026

Research Papers

Novel Phosphatase SSU72 Drives Malignant Progression in Colorectal Cancer via PERK^Thr982 Dephosphorylation Mediated Endoplasmic Reticulum Stress Inactivation Dongming Liu, Yuchao He, Wenshuai Chen, Zhonghao Sun, Wenchen Gong, Yu Wang, Jiaqi Ni, Yi Luo, Liwei Chen, Changfu Liu, Hua Li, Hua Guo Int. J. Biol. Sci. 2026; 22(13): 6876-6891. doi:10.7150/ijbs.129555 Full text PDF

Targeting Mitochondrial PD-L1 O-GlcNAcylation to Sensitize HBV-Related HCC to Immunotherapy: Modulating Golgi-mitochondrial Crosstalk and mTOR/PGC-1α-Driven Mitochondrial Biogenesis to Overcome Resistance Ze-Bang Du, Xin-Yu Ma, Han-Yu Zhang, Jia-Ming Lei, Xin-Xin He, Wen-Qi Xu, Wen-Dan Zhou, Xiao-Gang Xia, Ao-Bo Zhuang, Xiao-Xuan Chen, You-Liang Yao, Wen-Gang Li, Yu-Chun Lin, Zhong-Ning Lin Int. J. Biol. Sci. 2026; 22(13): 6892-6913. doi:10.7150/ijbs.126948 Full text PDF

DHA Targets RAB1B to Mediate the Driving Force Transmission of Copper Ion Vesicular Endocytosis Under Copper Overload for Promoting Cuproptosis and Ferroptosis in Hepatic Stellate Cells Xinran Qiu, Haoyuan Tian, Shujiang Sun, Ningyu Qiu, Biao Xu, Junrui Wang, Yuanyuan Gao, Zhengyang Bao, Xiang Han, Jie Zeng, Yuxin Lin, Feng Zhang, Shizhong Zheng, Jiangjuan Shao Int. J. Biol. Sci. 2026; 22(13): 6914-6944. doi:10.7150/ijbs.134520 Full text PDF

Interleukin-39 aggravates sepsis by inducing self-sustaining neutrophil activation in the lungs via the CXCL1-CXCR2 pathway Jinming Zhang, Jingting Liu, Yihui Wang, Yifan Xu, Robim M Rodrigues, Zihan Zhou, Jie Lu, Ziqiang Li, Xiaolin Wang, Jingjiao Li, Yong He, Fouad Lafdil, Ruidong Mo, Enqiang Mao, Qing Xie, Xiaogang Xiang Int. J. Biol. Sci. 2026; 22(13): 6945-6968. doi:10.7150/ijbs.124607 Full text PDF

Enhanced WWP2 Exacerbates Podocyte Injury in Lupus Nephritis through Monoubiquitylating H2A at K119 Ran You, Yuteng Jiang, Yingyi Xu, Qianying Liu, Menglei Gu, Yue Zhang, Zhanjun Jia, Mengqiu Wu, Mi Bai, Aihua Zhang Int. J. Biol. Sci. 2026; 22(13): 6969-6984. doi:10.7150/ijbs.131475 Full text PDF

Calcitriol Modulates Age-dependent Drug Response in Paired Patient-derived Normal and Tumor Colorectal Organoids Asunción Fernández-Barral, Antonio Barbáchano, Silvia Rodríguez-Marrero, Luis del Peso, Alfonso Herreros-Cabello, Estrella Arroyo-Gascón, Nuria Rodríguez-Salas, Isabel Prieto, Aurora Burgos, Miguel León-Arellano, Damián García-Olmo, Tomás Olleros, José Manuel González-Sancho, María Jesús Larriba, Alberto Muñoz Int. J. Biol. Sci. 2026; 22(13): 7003-7017. doi:10.7150/ijbs.131639 Full text PDF

Elimination of Senescent Macrophages by Purinergic Receptor P2RX7 Antagonist to Safeguard Against Kidney Injury and Aging Lei Tang, Letian Yang, Ruijia Zhang, Jian Li, Fan Guo, Haoyu Ye, Ping Zhou, Fei Liu, Liang Ma, Ping Fu Int. J. Biol. Sci. 2026; 22(13): 7082-7099. doi:10.7150/ijbs.138299 Full text PDF

Neutrophil extracellular traps promote neuronal ferroptosis through STING-mediated AMPK dysregulation after traumatic brain injury Guihong Shi, Jianye Xu, Yue Tian, Yiyao Cao, Shaochen Yu, Qifeng Li, Luyuan Zhang, Kaiyuan Huang, Rui Tan, Xiujue Zheng, Renya Zhan Int. J. Biol. Sci. 2026; 22(13): 7100-7126. doi:10.7150/ijbs.130882 Full text PDF

Deficiency of GLUT1 in macrophages reprograms tumor-associated macrophages to normalize tumor vasculature and retards the progression of tumors Yuan Fang, Wei Zou, Ling Ning, Tianle Li, Ying Huang, Xiaoxiong Song, Mengyuan Gao, Ruiqin Jia, Mingxi Zhu, Wenshi Qiu, Kexin Liu, Aiyun Wang, Jia Li, Yin Lu, Yang Zhao Int. J. Biol. Sci. 2026; 22(13): 7127-7150. doi:10.7150/ijbs.131425 Full text PDF

Pharmacological Blockade of NMUR2 Suppresses Glioma Growth by Inhibiting STAT5-Mediated Transcription of Cell Cycle-associated Genes Yuna Roh, Taesang Son, Tae-Hee Han, Sarang Kim, Eunsun Jung, Jin-Seong Hwang, Joo-Young Im, Mi-Jung Kang, Mun Jeong Cho, Jung Hwa Lim, Cho-Rok Jung, Moo-Seung Lee, Hyun-Soo Cho, Dae-Soo Kim, Mi-Young Son, Seon-Young Kim, Seon-Kyu Kim, Hyun Seung Ban, Jang-Seong Kim, Tae-Su Han Int. J. Biol. Sci. 2026; 22(13): 7151-7172. doi:10.7150/ijbs.135596 Full text PDF

Targeting the heparan sulfate proteoglycan/heparanase axis as a novel therapeutic strategy to drive adipogenesis and block tumor growth of dedifferentiated liposarcoma Cinzia Lanzi, Enrica Favini, Laura Dal Bo, Monica Tortoreto, Stefano Percio, Valentina Zuco, Gian Paolo Dagrada, Silvia Brich, Paola Collini, Loris De Cecco, Dario Callegaro, Roberta Sanfilippo, Alessandro Gronchi, Nadia Zaffaroni, Yehuda G. Assaraf, Sandro Pasquali, Giuliana Cassinelli Int. J. Biol. Sci. 2026; 22(13): 7173-7190. doi:10.7150/ijbs.133802 Full text PDF

AMOTL2 inhibits lymph node metastasis in gastric cancer by suppressing TGF-β/Smad signaling and is destabilized by the E3 ubiquitin ligase SMURF1 Huizhen Wang, Bo Yang, Changqing Lin, Yigao Wang, Yida Lu, Jing Li, Jianhui Li, Kexun Yu, Mingliang Wang, Pengpeng Liu, Yuexiang Wang, Yongxiang Li Int. J. Biol. Sci. 2026; 22(13): 7191-7208. doi:10.7150/ijbs.135795 Full text PDF

From Cysteamine to Pepstatin A: Targeting Cathepsin D To Improve Bone Health in Cystinosis Giulia Battafarano, Michela Rossi, Olivia Pagliarosi, Laura Di Giuseppe, Jacopo Di Gregorio, Sara Terreri, Cristiano De Stefanis, Marco Pezzullo, Gianna Di Giovamberardino, Pamela Vernocchi, Valeria Marzano, Lorenza Putignani, Jessica D'Amico, Fiorella Piemonte, Anna Taranta, Francesco Emma, Andrea Del Fattore Int. J. Biol. Sci. 2026; 22(13): 7209-7224. doi:10.7150/ijbs.135791 Full text PDF

Margin-enriched CD4⁺ central-memory T cells affect macrophages via ANXA1-FPR1 signaling axis to promote tumor progression in Intrahepatic cholangiocarcinoma Zhifeng Jiang, Ao Huang, Runze Miao, Shiyu Zhang, Feiyu Chen, Yang Xu, Jiayan Yan, Lixing Li, Senquan Zhang, Rongkui Luo, Wen Huang, Haixiang Sun, Xinrong Yang, Jian Zhou Int. J. Biol. Sci. 2026; 22(13): 7225-7239. doi:10.7150/ijbs.136469 Full text PDF

Chlorogenic acid promotes mtDNA leakage to enhance cGAS-STING induced anti-tumor immunity via ATF5-mtHSP70-TFAM system Rui Li, Ping Zhou, Chu-juan Hu, Ge Si, Ling Ren, Jin-jin Cui, Ying-ying He, Yan-xing Han, Jie Zhang, Wen-bin Li, Lu-lu Wang, Jian-dong Jiang Int. J. Biol. Sci. 2026; 22(13): 7277-7294. doi:10.7150/ijbs.136878 Full text PDF

piRNA-46403 Promotes Sertoli Cell Ferroptosis via Disrupting m5C-dependent USP18 mRNA Stabilization in Varicocele-mediated Infertility Xiao Fang, Li Song, Dong Liu, Zhixiang Xin, Wenjuan Pang, Qiang Tong, Jing Huang, Anbang Wang, Lei Yin, Hejing Huang, Aimin Jiang, Shancheng Ren Int. J. Biol. Sci. 2026; 22(13): 7295-7315. doi:10.7150/ijbs.137298 Full text PDF

Artificial intelligence-assisted reinterpretation of preclinical progeria research suggests a hierarchical nuclear-vascular resilience framework with translational implications Paolo Madeddu, Monica Cattaneo, Annibale Alessandro Puca Int. J. Biol. Sci. 2026; 22(13): 7349-7357. doi:10.7150/ijbs.133754 Full text PDF

The Acidic Exosomal miR-1246/WASF3 Axis Regulates Hepatic Stellate Cell Activation and Stiff ECM Remodeling to Promote Pancreatic Ductal Adenocarcinoma Liver Metastasis Dongqi Li, Xiangyu Chu, Fusheng Zhang, Yongsu Ma, Weikang Liu, Ping Li, Xiaocui Fang, Chen Wang, Xiaodong Tian, Yanlian Yang, Yinmo Yang Int. J. Biol. Sci. 2026; 22(13): 7358-7379. doi:10.7150/ijbs.132772 Full text PDF

DNAJB4 Protects Against Atherosclerosis by Stabilizing the HSP70-LXRα Axis in Hepatic Lipid Metabolism Wen-Hua Chen, Chia-Hui Chen, Man-Chen Hsu, Po-An Hu, Hsueh-Te Lee, Hsuan-Yun Hu, Kang-Yi Su, Wei-Lun Hsu, Tzong-Shyuan Lee Int. J. Biol. Sci. 2026; 22(13): 7380-7400. doi:10.7150/ijbs.131807 Full text PDF

Celastrol-Based Hybrid Prodrug Ameliorates ALI by Spatiotemporally Consecutive Dual-Targeting GLUT1/Drp1 to Reestablish Mitochondrial Homeostasis Hong Xu, Hongyu Chen, Fengling He, Xinlan Li, Wanxin Li, Qingqing Yang, Tingting Zhang, Jin Liu, Xiaoke Shi, Shilin Chen, Defang Li, Jun Lu Int. J. Biol. Sci. 2026; 22(13): 7427-7446. doi:10.7150/ijbs.133756 Full text PDF

Cross-tissue single-cell atlas reveals Id2 promotes sepsis-induced tissue damage by mediating macrophage metabolic reprogramming via Pkm2 Xiaodan Wang, Yiyan Liu, Yuanqun Zhou, Liyong Zou, Xiaowei Zhou, Zhongyuan Du, Daiqin Bao, Yibo Zhao, Yu Zhu, Yue Wu, Xingnan Ouyang, Li Wang, Liangming Liu, Tao Li Int. J. Biol. Sci. 2026; 22(13): 7471-7486. doi:10.7150/ijbs.136855 Full text PDF

Reviews

CAR T Cell Therapy in Lung Cancer: Overcoming Tumor Microenvironment-Mediated Barriers Lu Liu, Dandan Liang, Cui Wang, Jian Li, Jie Tang, Weimin Li, Xijie Yu Int. J. Biol. Sci. 2026; 22(13): 6985-7002. doi:10.7150/ijbs.131261 Full text PDF

Targeting Folate Receptors for the Detection and Selective Treatment of Cancer: Advanced Precision Oncology in Practice Michal Stark, Yehuda G. Assaraf Int. J. Biol. Sci. 2026; 22(13): 7018-7052. doi:10.7150/ijbs.139733 Full text PDF

Post-Translational Modifications in Cancer-Associated CD8⁺ T-Cell Exhaustion: Mechanisms and Therapeutic Opportunities Yongqi Lv, Qihang Shang, Yang Yu, Yahui Fu, Lijuan Liu, Changgang Sun Int. J. Biol. Sci. 2026; 22(13): 7053-7081. doi:10.7150/ijbs.138638 Full text PDF

The Role of Biomechanical Regulation in Physiological and Pathological Pregnancy: From Mechanotransduction to Clinical Implications Tingting Wang, Wanru Chen, Huixia Yang, Jie Yan Int. J. Biol. Sci. 2026; 22(13): 7240-7258. doi:10.7150/ijbs.134599 Full text PDF

The Role of Distinct Cancer-Associated Fibroblast Subtypes in Prostate Cancer Immunotherapy Kankan He, Zhite Zhao, Jianhui Bai, Tong Lu, Yaohua Hu, Xinglin He, Fanchao Wei, Yixin Zhang, Yanan Gu, Zhaokun Shi, Xiangliang Meng, Fuli Wang, Changhong Shi, Weijun Qin, Keying Zhang, Qiaoli Xie, Lijun Yang Int. J. Biol. Sci. 2026; 22(13): 7259-7276. doi:10.7150/ijbs.132227 Full text PDF

The Triad of NF-κB, HIF-1α, and Oxidative Stress in Hepatocellular Carcinoma: Pathogenesis, Clinical Challenges, and Therapeutic Potential of CIGB-552 in Liver Transplantation Xufan Cai, Muqiong Xing, Qianrang Lu, Julio R. Fernández Massó, Brizaida Oliva Arguelles, Maidel Carpio Alvarez, Ming Chen, Qi Ling Int. J. Biol. Sci. 2026; 22(13): 7316-7331. doi:10.7150/ijbs.137642 Full text PDF

Mitophagy and Cellular Homeostasis in Kidney Diseases: Mechanisms and Potential Therapeutics Hao Lu, Shenyu Yan, Baoyi Shao, Jianbo Guo, Yifan Wang, Rui Hou, Shen Chen, Meicen Wu, Biao Wei, Fei Li, Xiaoming Meng, Haiyong Chen Int. J. Biol. Sci. 2026; 22(13): 7332-7348. doi:10.7150/ijbs.138435 Full text PDF

FOXP3 Stability-Adaptation Paradox: Reshaping Treg-Based Therapies for Intestinal Diseases Yushuo Ren, Xiaohui Liu, Boya Wang, Haoyuan Yin, Jiatong Zhao, Shuzi Xin, Hongli Wang, Yuchen Zhang, Xinyue Liu, Jingyu Liu, Rongxuan Hua, Xiang Tian, Yuhang Bian, Sijin Gu, Haoxuan Zhang, Tong Wei, Lei Gao, Xin Lu, Hongwei Shang, Han Gao, Jingdong Xu Int. J. Biol. Sci. 2026; 22(13): 7401-7426. doi:10.7150/ijbs.137066 Full text PDF

RNA Triple Helices: From Structures and Mechanisms to Therapeutic Targets Yiqi Ding, Zhechao Wang, Zimo Wu, Benyuan Cao, Haiyang Dong, Yongfeng Jin Int. J. Biol. Sci. 2026; 22(13): 7447-7470. doi:10.7150/ijbs.132736 Full text PDF

Commentary

Orthotopic Porcine Liver and Kidney Xenotransplantation as a Step Toward Multi-Organ Replacement Hwijin Kim, Jongwon Byun, Sun-Uk Kim, Taeho Kwon, Kyungjun Uh Int. J. Biol. Sci. 2026; 22(13): 7487-7490. doi:10.7150/ijbs.139541 Full text PDF