The role of ubiquitination and deubiquitination in tumor invasion and metastasis

Han, Shuangze; Wang, Ruike; Zhang, Yangnan; Li, Xiaoying; Gan, Yu; Gao, Feng; Rong, Pengfei; Wang, Wei; Li, Wei

doi:10.7150/ijbs.69411

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Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

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Int J Biol Sci 2022; 18(6):2292-2303. doi:10.7150/ijbs.69411 This issue Cite

Review

The role of ubiquitination and deubiquitination in tumor invasion and metastasis

Shuangze Han¹, Ruike Wang¹, Yangnan Zhang¹, Xiaoying Li¹, Yu Gan¹, Feng Gao^3✉, Pengfei Rong^1,2✉, Wei Wang^1,2✉, Wei Li^1,2✉

1. Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China
2. Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
3. Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China

Citation:

Han S, Wang R, Zhang Y, Li X, Gan Y, Gao F, Rong P, Wang W, Li W. The role of ubiquitination and deubiquitination in tumor invasion and metastasis. Int J Biol Sci 2022; 18(6):2292-2303. doi:10.7150/ijbs.69411. https://www.ijbs.com/v18p2292.htm

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Abstract

Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.

Keywords: ubiquitination, E3 ubiquitin ligase, deubiquitinase, metastasis

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APA

Han, S., Wang, R., Zhang, Y., Li, X., Gan, Y., Gao, F., Rong, P., Wang, W., Li, W. (2022). The role of ubiquitination and deubiquitination in tumor invasion and metastasis. International Journal of Biological Sciences, 18(6), 2292-2303. https://doi.org/10.7150/ijbs.69411.

ACS

Han, S.; Wang, R.; Zhang, Y.; Li, X.; Gan, Y.; Gao, F.; Rong, P.; Wang, W.; Li, W. The role of ubiquitination and deubiquitination in tumor invasion and metastasis. Int. J. Biol. Sci. 2022, 18 (6), 2292-2303. DOI: 10.7150/ijbs.69411.

NLM

CSE

Han S, Wang R, Zhang Y, Li X, Gan Y, Gao F, Rong P, Wang W, Li W. 2022. The role of ubiquitination and deubiquitination in tumor invasion and metastasis. Int J Biol Sci. 18(6):2292-2303.

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