Int J Biol Sci 2022; 18(12):4756-4767. doi:10.7150/ijbs.72461 This issue

Review

COVID-19 Pandemic: Insights into Interactions between SARS-CoV-2 Infection and MAFLD

Hanfei Chen1,2, Qiang Chen1,2,3✉

1. Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
2. Centre for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
3. MOE Frontier Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China.

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Citation:
Chen H, Chen Q. COVID-19 Pandemic: Insights into Interactions between SARS-CoV-2 Infection and MAFLD. Int J Biol Sci 2022; 18(12):4756-4767. doi:10.7150/ijbs.72461. Available from https://www.ijbs.com/v18p4756.htm

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Abstract

Graphic abstract

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become an ongoing global health pandemic. Since 2019, the pandemic continues to cast a long shadow on all aspects of our lives, bringing huge health and economic burdens to all societies. With our in-depth understanding of COVID-19, from the initial respiratory tract to the later gastrointestinal tract and cardiovascular systems, the multiorgan involvement of this infectious disease has been discovered. Metabolic dysfunction-associated fatty liver disease (MAFLD), formerly named nonalcoholic fatty liver disease (NAFLD), is a major health issue closely related to metabolic dysfunctions, affecting a quarter of the world's adult population. The association of COVID-19 with MAFLD has received increasing attention, as MAFLD is a potential risk factor for SARS-CoV-2 infection and severe COVID-19 symptoms. In this review, we provide an update on the interactions between COVID-19 and MAFLD and its underlying mechanisms.

Keywords: COVID-19, SARS-CoV-2, MAFLD, NAFLD, Liver injury