Int J Biol Sci 2022; 18(14):5329-5344. doi:10.7150/ijbs.76134 This issue

Review

Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions

Ye Zhang1#, Ran Guo2#, Shan-Shan Wang1, Xiao-You Jiang1, Hong-Yan Cui1, Yang Guo1, Xiao-Yu Song1✉, Qi-Qiang Guo1✉, Liu Cao1✉

1. College of Basic Medical Science, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning Province, P. R. China.
2. Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, P.R. China.
#These authors contributed equally to this work.

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Citation:
Zhang Y, Guo R, Wang SS, Jiang XY, Cui HY, Guo Y, Song XY, Guo QQ, Cao L. Autophagy-related Proteins in Genome Stability: Autophagy-Dependent and Independent Actions. Int J Biol Sci 2022; 18(14):5329-5344. doi:10.7150/ijbs.76134. Available from https://www.ijbs.com/v18p5329.htm

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Abstract

Graphic abstract

It is emerging that autophagy-related proteins regulate the adaptive response to DNA damage in maintaining genome stability at multiple pathways. Here, we discuss recent insights into how autophagy-related proteins participate in DNA damage repair processes, influence chromosomal instability, and regulate the cell cycle through autophagy-dependent and independent actions. There is increasing awareness of the importance of these pathways mediated by autophagy-related proteins to DNA damage response (DDR), and disturbances in these regulatory connections may be linked to genomic instability participated in various human diseases, such as cancer and aging.

Keywords: Autophagy-related proteins, Genome Stability, Autophagy, Non-autophagic functions