Int J Biol Sci 2022; 18(14):5329-5344. doi:10.7150/ijbs.76134 This issue
1. College of Basic Medical Science, Health Sciences Institute, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning Province, P. R. China.
2. Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, P.R. China.
#These authors contributed equally to this work.
It is emerging that autophagy-related proteins regulate the adaptive response to DNA damage in maintaining genome stability at multiple pathways. Here, we discuss recent insights into how autophagy-related proteins participate in DNA damage repair processes, influence chromosomal instability, and regulate the cell cycle through autophagy-dependent and independent actions. There is increasing awareness of the importance of these pathways mediated by autophagy-related proteins to DNA damage response (DDR), and disturbances in these regulatory connections may be linked to genomic instability participated in various human diseases, such as cancer and aging.
Keywords: Autophagy-related proteins, Genome Stability, Autophagy, Non-autophagic functions