Int J Biol Sci 2023; 19(4):1316-1335. doi:10.7150/ijbs.81518 This issue Cite

Review

Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder

Jie-quan Wang1,3,4,5#, Ya-ru Liu2,6#✉, Qing-rong Xia1,3,4,5, Jun Liang1,3,4,5, Jin-liang Wang1,3,4,5, Jun Li7✉

1. Department of Pharmacy, Affiliated Psychological Hospital of Anhui Medical University, Hefei, 230000, China
2. Department of Pharmacy, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China
3. Department of Pharmacy, Hefei Fourth People's Hospital, Hefei, 230000, China
4. Psychopharmacology Research Laboratory, Anhui Mental Health Center, Hefei, 230000, China
5. Anhui Clinical Research Center for Mental Disorders, Hefei,230000, China
6. The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei, 230022, China
7. Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China
# These authors contributed equally to this work.

Citation:
Wang Jq, Liu Yr, Xia Qr, Liang J, Wang Jl, Li J. Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. Int J Biol Sci 2023; 19(4):1316-1335. doi:10.7150/ijbs.81518. https://www.ijbs.com/v19p1316.htm
Other styles

File import instruction

Abstract

Graphic abstract

Alcohol use disorder (AUD) is one of the most prevalent neuropsychological disorders worldwide, and its pathogenesis is convoluted and poorly understood. There is considerable evidence demonstrating significant associations between multiple heritable factors and the onset and progression of AUD. In recent years, a substantial body of research conducted by emerging biotechnologies has increasingly highlighted the crucial roles of noncoding RNAs (ncRNAs) in the pathophysiology of mental diseases. As in-depth understanding of ncRNAs and their mechanisms of action, they have emerged as prospective diagnostic indicators and preclinical therapeutic targets for a variety of psychiatric illness, including AUD. Of note, dysregulated expression of ncRNAs such as circRNAs, lncRNAs and miRNAs was routinely found in AUD individuals, and besides, exogenous regulation of partial ncRNAs has also been shown to be effective in ameliorating alcohol preference and excessive alcohol consumption. However, the exact molecular mechanism still remains elusive. Herein, we systematically summarized current knowledge regarding alterations in the expression of certain ncRNAs as well as their-mediated regulatory mechanisms in individuals with AUD. And finally, we detailedly reviewed the potential theranostics applications of gene therapy agents targeting ncRNAs in AUD mice. Overall, a deeper comprehension of functional roles and biological mechanisms of ncRNAs may make significant contributions to the accurate diagnosis and effective treatment of AUD.

Keywords: alcohol use disorder, noncoding RNAs, emerging biotechnology, gene therapy agents, regulatory mechanisms, theranostics applications


Citation styles

APA
Wang, J.q., Liu, Y.r., Xia, Q.r., Liang, J., Wang, J.l., Li, J. (2023). Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. International Journal of Biological Sciences, 19(4), 1316-1335. https://doi.org/10.7150/ijbs.81518.

ACS
Wang, J.q.; Liu, Y.r.; Xia, Q.r.; Liang, J.; Wang, J.l.; Li, J. Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. Int. J. Biol. Sci. 2023, 19 (4), 1316-1335. DOI: 10.7150/ijbs.81518.

NLM
Wang Jq, Liu Yr, Xia Qr, Liang J, Wang Jl, Li J. Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. Int J Biol Sci 2023; 19(4):1316-1335. doi:10.7150/ijbs.81518. https://www.ijbs.com/v19p1316.htm

CSE
Wang Jq, Liu Yr, Xia Qr, Liang J, Wang Jl, Li J. 2023. Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder. Int J Biol Sci. 19(4):1316-1335.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image