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Int J Biol Sci 2023; 19(13):4311-4326. doi:10.7150/ijbs.83531 This issue Cite

Review

The Evolution of Tumor Microenvironment in Gliomas and Its Implication for Target Therapy

Yang Hu^*,1, Zhixing Li^*,1, Yichi Zhang^*,1, Yuzheng Wu¹, Zihao Liu¹, Jianhao Zeng³, Zhexue Hao¹, Jin Li^1✉, Jiaoyan Ren^2✉, Maojin Yao^1✉#

1. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, 510182, China.
2. School of Food Sciences and Engineering, South China University of Technology, Guangzhou, 510641, China.
3. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA.
* These authors contributed equally to this work.
#Leading corresponding author.

✉ Corresponding authors: Maojin Yao, yaomaojincn. Jiaoyan Ren, jyrenedu.cn (J. Ren); Jin Li, JinLedu.cn.

Abstract

Gliomas develop in unique and complicated environments that nourish tumor cells. The tumor microenvironment (TME) of gliomas comprises heterogeneous cells, including brain-resident cells, immune cells, and vascular cells. Reciprocal interactions among these cells are involved in the evolution of the TME. Moreover, the study of attractive therapeutic strategies that target the TME is transitioning from basic research to the clinic. Mouse models are indispensable tools for dissecting the processes and mechanisms leading to TME evolution. In this review, we overview the paradoxical roles of the TME, as well as the recent progress of mouse models in TME research. Finally, we summarize recent advances in TME-targeting therapeutic strategies.

Keywords: Glioma, Tumor microenvironment, Tumor evolution, Targeted therapy, Mouse model

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