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Int J Biol Sci 2024; 20(1):15-28. doi:10.7150/ijbs.83586 This issue Cite

Review

Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer

Wei Zhou1,2, Adrian Lim1, Mouad Edderkaoui1, Arsen Osipov1, Heshui Wu2✉, Qiang Wang1✉, Stephen Pandol1✉

1. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
2. Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

✉ Corresponding authors: Dr. Stephen Pandol (e-mail: Stephen.Pandolorg), Dr. Heshui Wu (e-mail: heshuiwuedu.cn) and Dr. Qiang Wang (e-mail: Qiang.Wangorg).

Citation:
Zhou W, Lim A, Edderkaoui M, Osipov A, Wu H, Wang Q, Pandol S. Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer. Int J Biol Sci 2024; 20(1):15-28. doi:10.7150/ijbs.83586. https://www.ijbs.com/v20p0015.htm
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Abstract

Graphic abstract

Although recent advances in cancer treatment significantly improved the prognosis of patients, drug resistance remains a major challenge. Targeting programmed cell death is a major approach of antitumor drug development. Deregulation of programmed cell death (PCD) contributes to resistance to a variety of cancer therapeutics. Yes-associated protein (YAP) and its paralog TAZ, the main downstream effectors of the Hippo pathway, are aberrantly activated in a variety of human malignancies. The Hippo-YAP pathway, which was originally identified in Drosophila, is well conserved in humans and plays a defining role in regulation of cell fate, tissue growth and regeneration. Activation of YAP signaling has emerged as a key mechanism involved in promoting cancer cell proliferation, metastasis, and drug resistance. Understanding the role of YAP/TAZ signaling network in PCD and drug resistance could facilitate the development of effective strategies for cancer therapeutics.

Keywords: Programmed cell death, YAP/TAZ, Apoptosis, Ferroptosis, Autophagy, Drug resistance

Citation styles

APA
Zhou, W., Lim, A., Edderkaoui, M., Osipov, A., Wu, H., Wang, Q., Pandol, S. (2024). Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer. International Journal of Biological Sciences, 20(1), 15-28. https://doi.org/10.7150/ijbs.83586.

ACS
Zhou, W.; Lim, A.; Edderkaoui, M.; Osipov, A.; Wu, H.; Wang, Q.; Pandol, S. Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer. Int. J. Biol. Sci. 2024, 20 (1), 15-28. DOI: 10.7150/ijbs.83586.

NLM
Zhou W, Lim A, Edderkaoui M, Osipov A, Wu H, Wang Q, Pandol S. Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer. Int J Biol Sci 2024; 20(1):15-28. doi:10.7150/ijbs.83586. https://www.ijbs.com/v20p0015.htm

CSE
Zhou W, Lim A, Edderkaoui M, Osipov A, Wu H, Wang Q, Pandol S. 2024. Role of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer. Int J Biol Sci. 20(1):15-28.

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