Int J Biol Sci 2011; 7(6):700-707. doi:10.7150/ijbs.7.700 This issue Cite

Research Paper

Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells

Mitra Shojania Feizabadi1 ✉, Tarynn M. Witten2

1. Physics Department, Seton Hall University, South Orange, NJ 07079, USA
2. Center for the Study of Biological Complexity, PO Box 842030, Virginia Commonwealth University, Richmond, VA 23284-2030, USA

Citation:
Feizabadi MS, Witten TM. Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. Int J Biol Sci 2011; 7(6):700-707. doi:10.7150/ijbs.7.700. https://www.ijbs.com/v07p0700.htm
Other styles

File import instruction

Abstract

In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotheraputic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations.

Keywords: Aging, tumor cell dynamics, normal cell dynamics, tumor-normal cell interactions, chemotherapy, Immune system, Immunotherapy, Immunodeficiency


Citation styles

APA
Feizabadi, M.S., Witten, T.M. (2011). Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. International Journal of Biological Sciences, 7(6), 700-707. https://doi.org/10.7150/ijbs.7.700.

ACS
Feizabadi, M.S.; Witten, T.M. Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. Int. J. Biol. Sci. 2011, 7 (6), 700-707. DOI: 10.7150/ijbs.7.700.

NLM
Feizabadi MS, Witten TM. Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. Int J Biol Sci 2011; 7(6):700-707. doi:10.7150/ijbs.7.700. https://www.ijbs.com/v07p0700.htm

CSE
Feizabadi MS, Witten TM. 2011. Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells. Int J Biol Sci. 7(6):700-707.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image