Int J Biol Sci 2011; 7(6):700-707. doi:10.7150/ijbs.7.700 This issue
1. Physics Department, Seton Hall University, South Orange, NJ 07079, USA
2. Center for the Study of Biological Complexity, PO Box 842030, Virginia Commonwealth University, Richmond, VA 23284-2030, USA
In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotheraputic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations.
Keywords: Aging, tumor cell dynamics, normal cell dynamics, tumor-normal cell interactions, chemotherapy, Immune system, Immunotherapy, Immunodeficiency