Volume 22, Issue 11

open access Global reach, higher impact

Volume 22 (11); 2026

Research Papers

Cholesterol Overload Drives Hepatic Steatosis by Inhibiting OGT-dependent PPARα O-GlcNAcylation and Transactivation Rui Guo, Yanhui Li, Qinchao Ding, Chad Slawson, Udayan Apte, Yuwei Jiang, Xiaobing Dou, Songtao Li, Zhenyuan Song Int. J. Biol. Sci. 2026; 22(11): 5615-5633. doi:10.7150/ijbs.135054 Full text PDF

The TRPM7 inhibitor carvacrol suppresses angiogenesis and vasculogenic mimicry in triple-negative breast cancer Tianci Tang, Na Zhao, Moqin Qiu, Luisa Müller, Michael D. Menger, Vladimir Chubanov, Thomas Gudermann, Gabriela Krasteva-Christ, Matthias W. Laschke, Yuan Gu Int. J. Biol. Sci. 2026; 22(11): 5634-5658. doi:10.7150/ijbs.130027 Full text PDF

Targeting the exosomal CaMK2A-ZDHHC3-GPX4 pathway reprograms tumor-associated macrophages and enhances anti-PD-1/PD-L1 immunotherapy in gastric cancer Zetian Chen, Hongxin Huang, Yikai Shen, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Tianlu Jiang, Zekuan Xu, Zheng Li Int. J. Biol. Sci. 2026; 22(11): 5659-5684. doi:10.7150/ijbs.128976 Full text PDF

Role of WDR66 in Stemness, Therapy Resistance and Tumor microenvironment modulation in Head and Neck Cancer Laura Sanchez-Diaz, Asuncion Espinosa-Sánchez A, Amancio Carnero Int. J. Biol. Sci. 2026; 22(11): 5685-5705. doi:10.7150/ijbs.130010 Full text PDF

PFKFB3 Mediated Glycolytic Reprogramming Drives Vascular Endothelial Injury Under Chronic Intermittent Hypoxia Shi Qi Li, Yi Wang, Liu Zhang, Ya Ru Yan, Fang Ying Lu, Xi Xi Chen, Ying Ni Lin, Jun Qi Lin, Jian Ping Zhou, Li Ming Lu, Qing Yun Li Int. J. Biol. Sci. 2026; 22(11): 5735-5753. doi:10.7150/ijbs.129280 Full text PDF

USP18 Impacts Cisplatin Resistance in Ovarian Cancer Cells by Modulating DNA Repair Cristina Corno, Matteo Costantino, Pietro Pettinari, Luca Mirra, Simone Stucchi, Noemi Arrighetti, Nunzio Perta, Giovanni Di Muccio, Mathilde Robin, Giovanni L. Beretta, Elisabetta Corna, Nives Carenini, Loredana Cleris, Diego Colombo, Elena Luison, Chiara Maura Ciniselli, Mara Lecchi, Paolo Verderio, Mariangela Figini, Stig Linder, Diego Tosi, Anna La Teana, Padraig D'Arcy, Paola Perego Int. J. Biol. Sci. 2026; 22(11): 5780-5798. doi:10.7150/ijbs.130399 Full text PDF

Slc1a2-mediated Glutamate Transport Promotes Dendritic Cell Immunity through Sema3A-regulated Cytoskeletal Remodeling and Migration Shanlin Chen, Bei Chen, Gongwei Li, Haoqiang Liu, Qiang Chen, Jiahao Chen, Yuekang Xu, Adila Aipire, Jinyao Li Int. J. Biol. Sci. 2026; 22(11): 5799-5821. doi:10.7150/ijbs.131305 Full text PDF

USP33 Promotes Lung Adenocarcinoma Brain Metastasis by Inhibiting the K48-Linked Ubiquitination and Degradation of S100A9 and Facilitating Vimentin Secretion Zihao Wang, Mengqi Chang, Yuekun Wang, Yang Qu, Wenbo Wu, Jiahui Liu, Xiaopeng Guo, Yidong Zhou, Wenbin Ma, Yu Wang Int. J. Biol. Sci. 2026; 22(11): 5852-5877. doi:10.7150/ijbs.127941 Full text PDF

WDR82 suppresses breast cancer progression by inhibiting ERK-driven chemokine expression and neutrophil infiltration Qinyi Yu, Jiang Yang, Fengjiao Lu, Wenxiu Liu, Zeyao Han, Yuanchao Bao, Xiaorui Xu, Jialei Xu, Wanfeng Gao, Boyi Cong, Yangyang Chai, Xuetao Cao Int. J. Biol. Sci. 2026; 22(11): 5878-5894. doi:10.7150/ijbs.135015 Full text PDF

Sleep Deprivation Promotes Colorectal Cancer in Apc^Min/+ Mice Associated with Modulation of Gut Microbiota and Related Metabolites Jia Chen, Rishun Su, Yong Kuang, Xiumin Liu, Yulong He, Jiong Chen, Changhua Zhang Int. J. Biol. Sci. 2026; 22(11): 5895-5910. doi:10.7150/ijbs.134241 Full text PDF

Fibrillin-1 Orchestrates a Pro-senescent Niche Driving Peritubular Endothelial Senescence via ZEB1/endothelin-1/β-catenin Signaling Junxin Huang, Xiaoyao Zhang, Zifu Yao, Yuxi Zhang, Di Huang, Yongsi Liu, Fan Fan Hou, Youhua Liu, Li Li Int. J. Biol. Sci. 2026; 22(11): 5911-5933. doi:10.7150/ijbs.133521 Full text PDF

Comprehensive Metabolomic Profiling of Skin Lesions from Psoriasis Patients Reveals Disease Signatures Peiyao Zhu, Yuanyuan Wang, Jie Sun, Jiangluyi Cai, Zeyu Chen, Lian Cui, Xinyi Song, Yuye Wang, Zengyang Yu, Yu Gong, Qian Yu, Yuling Shi Int. J. Biol. Sci. 2026; 22(11): 5934-5952. doi:10.7150/ijbs.134115 Full text PDF

H3K18la-PSMG1 Axis in Bladder Cancer Progression: Curcumin as a Therapeutic Candidate Zhe Yu, Jinge Zhang, Zihuan Wang, Shu Wei, Chen Chen, Yuan Huang, Qin Fan, Fan Deng, Haiyong Chen, Zhangfeng Zhong, Lina Hou, Wanlong Tan, Fei Li Int. J. Biol. Sci. 2026; 22(11): 5953-5968. doi:10.7150/ijbs.135180 Full text PDF

Targeting IL-1α Sensitizes HNSCC to PDT by Reversing Hypoxia and NF-κB-Driven Oxidative Stress Resistance Zhiyin Li, Yikang Ji, Xinran Zhao, Hexin Ma, Wanling Chen, Zijie Zhou, Xu Wang, Lingyue Shen, Lingyan Zheng Int. J. Biol. Sci. 2026; 22(11): 5988-6008. doi:10.7150/ijbs.131696 Full text PDF

Nicotinamide riboside reduces glial inflammation and boosts mitochondrial function Tsering Yangzom, Anbin Chen, Bjørn Christian Lundberg, Kristina Xiao Liang Int. J. Biol. Sci. 2026; 22(11): 6035-6063. doi:10.7150/ijbs.119262 Full text PDF

CD109 Drives Stemness and Chemoresistance in Colorectal Cancer via LRRC8A/AKAP12/PKCα-Mediated STAT3 Activation and WNT Signaling Rubén A. Bartolomé, Tania Calvo-López, Pablo Otero-Núñez, María Estaras, Asunción Fernández-Barral, Antonio Barbáchano, Issam Boukich, María Cuerda-López, Mª Jesús Fernández-Aceñero, Gorane Rodríguez-Urquirizar, Ana Mariscal-Casero, Miguel Padilla-Blanco, María Montoya, Ana O'Loghlen, José M. Fernández-Fernández, Jose Manuel Gonzalez-Sancho, J. Ignacio Casal Int. J. Biol. Sci. 2026; 22(11): 6064-6083. doi:10.7150/ijbs.127856 Full text PDF

RMAD1, a Novel Cell-Penetrating Peptide Derived from ADARB2: Preclinical Insights into Antigen Uptake and T Cell Activation Chaemin Lim, Chanho Park, Ee Chan Song, Yungyeong Shin, Wan Ki Kim, Yu Jin Park, Hyejoo Youn, Cheolmin Ham, Sang Bum Kim, Seongmin Cho Int. J. Biol. Sci. 2026; 22(11): 6084-6099. doi:10.7150/ijbs.132948 Full text PDF

Dual inhibition of PRMT1 and SUV39H1 suppresses breast cancer progression and enhances immunotherapy response Ge Wang, Jiagui Song, Xinwei Duan, Kunhao Zhou, Jing Zhang, Hongquan Zhang, Yu Yu Int. J. Biol. Sci. 2026; 22(11): 6100-6114. doi:10.7150/ijbs.130955 Full text PDF

Unveiling Interleukin-40: A Novel Regulator of Macrophage and B Cell Function in Allergic Asthma Aixuan Li, Katie Ching-Yau Wong, Danqi Huang, Fang Chen, Haoxuan Li, Xun Gao, Ting-Fan Leung, Gary Wing-Kin Wong, Wing-Hung Ko, Chun-Kwok Wong Int. J. Biol. Sci. 2026; 22(11): 6115-6131. doi:10.7150/ijbs.128164 Full text PDF

Spatial and single-cell transcriptomics reveal a HIF-1α/NF-κB-driven hypoxia-induced senescence axis in BPH epithelium Zheng Li, Shuai Hu, Zhifu Liu, Muqiu Zhang, Shengbin Chen, Wei Yu, Mingxia Ding, Yu Fan, Senmao Li, Jie Jin Int. J. Biol. Sci. 2026; 22(11): 6149-6176. doi:10.7150/ijbs.130242 Full text PDF

Targeting QRICH1 suppresses epithelial-mesenchymal transition and tumor growth in liver cancer through the Connexin43/USP1 mediated Snail1 stabilization Su-Yeon Park, Bum-Sang Shim, Bonglee Kim, Sung-Hoon Kim Int. J. Biol. Sci. 2026; 22(11): 6177-6195. doi:10.7150/ijbs.133080 Full text PDF

Targeting THOC2-Mediated mRNA Export Induces PARP Inhibitor Vulnerability in DNA Repair-Competent Hepatocellular Carcinoma Xinli Li, Songpeng Yang, Mengxin Zhang, Zhaoyu Guo, Yan Wang, Yanru Meng, Yuanping Liu, Hu Zhang, Kaikun Xu, Xiuyuan Zhang, Yuanjun Zhai, Jingzhuo Jin, Fuchu He, Chunyan Tian, Aihua Sun Int. J. Biol. Sci. 2026; 22(11): 6196-6217. doi:10.7150/ijbs.131002 Full text PDF

Cancer-associated adipocytes confer CDK4/6 inhibitor resistance in ER+ breast cancer through an IL-6/STAT3/SREBF2 axis coupled with cholesterol metabolism and cell cycle reprogramming Renhong Huang, Yiwei Tong, Xi Sun, Haoyu Wang, Zheng Wang, Yujie Tang, Kunwei Shen, Xiaosong Chen Int. J. Biol. Sci. 2026; 22(11): 6218-6236. doi:10.7150/ijbs.130653 Full text PDF

Targeting SRSF6 to Enhance Cisplatin Sensitivity by Modulating Redox Balance via NFE2L1 exon 4 Splicing in ESCC Xinyu He, Jialuo Xu, Lina Duan, Jing Ma, Dan Gao, Yifei Xie, Dengyun Zhao, Jialin Liu, Jimin Zhao, Fangfang Liu, Mee-Hyun Lee, Myoung Ok Kim, Zigang Dong, Yanan Jiang, Kangdong Liu Int. J. Biol. Sci. 2026; 22(11): 6237-6260. doi:10.7150/ijbs.131590 Full text PDF

Reviews

Copper-Iron Cell Death Axis: Mechanistic Crosstalk, Disease Implications and an Integrated Metallo-Redox-Metabolic Framework HaoQi Huang, YuLu Chen, Yi Lu, ZiLong Yuan, Ahmed Zahoor, LiPing Ren, YuanYuan Luo, BaoCai Zhong, Jian Huang, Hui Chen, Lin Ning Int. J. Biol. Sci. 2026; 22(11): 5706-5734. doi:10.7150/ijbs.132221 Full text PDF

Macrophage-Orchestrated Metabolic Sensing Drives IBD Pathogenesis: A Framework for Targeted Therapy Guangqi Guan, Xuelin Sun, Yaoxing Chen, Qingyun Guo, Yulan Dong Int. J. Biol. Sci. 2026; 22(11): 5754-5779. doi:10.7150/ijbs.131531 Full text PDF

Reimagining AHR in Cancer: From Environmental Sensor to Novel Immunomodulatory Therapeutic Target Yuanhao Peng, Yaxin Zhao, Yangying Zhou, Shuang Liu, Desheng Xiao, Yongguang Tao Int. J. Biol. Sci. 2026; 22(11): 5822-5851. doi:10.7150/ijbs.129455 Full text PDF

RNA variation as the driver of genomic efficiency and phenotypic complexity Zhihua Jiang, Michee van Rooyen, Jennifer J. Michal, Isyana Khaerunnisa, Saiful Anwar, Xing Fu, Jinzeng Yang, Steve P. Miller Int. J. Biol. Sci. 2026; 22(11): 5969-5987. doi:10.7150/ijbs.135200 Full text PDF

Esophageal Small Cell Carcinoma: From Bench Discoveries to Bedside Therapeutics Zhe Wang, Jiayi Zhang, Cheng Ji, Jingxin Yu, Bangkun Shen, Xiangrui Meng, Zhengzheng Shan, Lulu Guan, Bingtong Yue, Dao Xin, Tongjin Zhao, Feng Wang Int. J. Biol. Sci. 2026; 22(11): 6009-6034. doi:10.7150/ijbs.133104 Full text PDF

Deciphering the Neuroautophagic Interactome: Molecular Circuits Linking Selective Autophagy to Neuropathological Cascades in Neurological Disorders Pengfei Luo, Zachary D. Travis, Cameron Lenahan, Haijian Wu, Jianmin Zhang, Jun Yu, Weilin Xu Int. J. Biol. Sci. 2026; 22(11): 6132-6148. doi:10.7150/ijbs.127431 Full text PDF