Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma

Zhi, Feng; Gong, Guangming; Xu, Yan; Zhu, Yan; Hu, Die; Yang, Yilin; Hu, Yiqiao

doi:10.7150/ijbs.3520

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Int J Biol Sci 2012; 8(2):289-297. doi:10.7150/ijbs.3520 This issue Cite

Short Research Communication

Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma

Feng Zhi^1,2, Guangming Gong¹, Yan Xu¹, Yan Zhu¹, Die Hu¹, Yilin Yang^2,✉, Yiqiao Hu^1,✉

1. State Key Laboratories of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
2. Third Affiliated Hospital of Soochow University, Changzhou, China

Citation:

Zhi F, Gong G, Xu Y, Zhu Y, Hu D, Yang Y, Hu Y. Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma. Int J Biol Sci 2012; 8(2):289-297. doi:10.7150/ijbs.3520. https://www.ijbs.com/v08p0289.htm

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Abstract

Neuroblastoma is an embryonic malignancy arising from neuroblasts. The mechanisms that regulate the origination of neuroblastoma are still not very clear. In this study, we revealed that 6-bromoindirubin 3'-oxime (BIO), a specific GSK-3β inhibitor, promoted N2A cells-derived neurons to become tumor-like neuroblasts. Moreover, constitutively activated β-catenin (S33Y) also promoted this process, whereas, silencing endogenous expression of β-catenin abolished BIO-induced effects. These results implicated the potential relationship between the Wnt/β-catenin signaling and neuroblastoma formation. Indeed, we found that the amount of β-catenin in nucleus, which indicated the activation of Wnt/β-catnin signaling, was accumulated in human neuroblastoma specimens and positively correlated with clinical risk of neuroblastoma. These results give us a new sight into the neuroblastoma initiation and progression, and provide a potential drug target for neuroblastoma treatment.

Keywords: Neuroblastoma, GSK-3β, β-catenin, neuroblasts

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APA

Zhi, F., Gong, G., Xu, Y., Zhu, Y., Hu, D., Yang, Y., Hu, Y. (2012). Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma. International Journal of Biological Sciences, 8(2), 289-297. https://doi.org/10.7150/ijbs.3520.

ACS

Zhi, F.; Gong, G.; Xu, Y.; Zhu, Y.; Hu, D.; Yang, Y.; Hu, Y. Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma. Int. J. Biol. Sci. 2012, 8 (2), 289-297. DOI: 10.7150/ijbs.3520.

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CSE

Zhi F, Gong G, Xu Y, Zhu Y, Hu D, Yang Y, Hu Y. 2012. Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma. Int J Biol Sci. 8(2):289-297.

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