International Journal of Biological Sciences
ISSN: 1449-2288
10
Impact Factor
ISSN: 1449-2288
Global reach, higher impactVolume 22 (5); 2026
Research Papers
Metabolic Adaptation of CD8⁺ T Cells Limits the Efficacy of Fatty Acid Oxidation Inhibition in Type 1 Diabetes
Manuel Salzmann, Laura Boccuni, Patrizia Gibler, Mira Brekalo, Tamara S. Trimmel, Elena T. Pichler, Patrick Haider, Julia L. Blesch, Christian Hengestenberg, Michael B. Fischer, Bruno K. Podesser, Remi J. Creusot, Julia B. Kral-Pointner, Philipp J. Hohensinner
Int. J. Biol. Sci. 2026; 22(5): 2196-2214. doi:10.7150/ijbs.125649
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Triptonide-mediated PTGS2 Inhibition Induces Autophagic Cell Death to Suppress the Progression of Triple-negative Breast Cancer and Epithelial Ovarian Cancer
Kunxiang Gong, Kai Song, Haotian Wang, Linye Li, Xiaomin Sun, Lingling Sun, Wenbo Hao, Zhe-Sheng Chen, Yinger Huang
Int. J. Biol. Sci. 2026; 22(5): 2215-2232. doi:10.7150/ijbs.127562
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PTPN1 Regulation via YBX1-PTBP1 Interaction Promotes Fibroblast Activation and Fibrotic Remodeling in the Lung
Huibing Liu, Cong Xia, Yingying Zhang, Yulong Gan, Lianhui Cheng, Xuqian Wang, Airu Chang, Wenyu Zhao, Bin Li, Yaxuan Wang, Yajun Li, Ivan Rosas, Juntang Yang, Guoying Yu, Lan Wang
Int. J. Biol. Sci. 2026; 22(5): 2233-2246. doi:10.7150/ijbs.123875
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MYC-Mediated Functional Manifestation of IDH1 Mutations in Intrahepatic Cholangiocarcinoma Confers Sensitivity to (+)-JQ1
Fangyanni Wang, Xinyu Liu, Ning Zhang, Ruirui Kong
Int. J. Biol. Sci. 2026; 22(5): 2247-2264. doi:10.7150/ijbs.123085
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CXCL8 Drives MMP1 Upregulation and Promotes Metastatic Progression in Oral Cancer Through CXCR1/2-Mediated JAK1/STAT3 Activation
Kuan-Chou Lin, Tsung-Ming Chang, Ying-Sui Sun, Yu-Rou Lin, Chih-Hsin Tang, Ju-Fang Liu
Int. J. Biol. Sci. 2026; 22(5): 2285-2301. doi:10.7150/ijbs.115990
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Interaction between m6A and YAP1 mechanotransduction pathways is essential for mechanical memory and matrix remodeling in pancreatic cancer
Jiaoshun Chen, Gengqiao Wang, Haoxiang Zhang, Qingyi Hu, Jun Zhao, Qiang Shen, Qingke Duan, Tao Yin
Int. J. Biol. Sci. 2026; 22(5): 2302-2323. doi:10.7150/ijbs.125330
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GFPT2 drives sunitinib resistance of renal cell carcinoma via enzyme-dependent and -independent manners
Songbo Wang, Jiajun Xing, Xiaoyi Wang, Zengjun Wang, Pengfei Shao, Chenkui Miao
Int. J. Biol. Sci. 2026; 22(5): 2324-2342. doi:10.7150/ijbs.118985
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ANXA1-mediated mTOR/FABP4 Inhibition Drives Antifibrotic Macrophage Reprogramming in Lupus Nephritis
Juan Tao, Qingyu Cheng, Pinjie Zhang, Guizhen Yu, Qi Chen, Manwen Yang, Qiqin Wu, Haopeng Fang, Haibo Wu, Xiaoyuan Song, Zhu Chen, Min Chen, Xiaoming Meng, Mingxing Lei, Tengchuan Jin
Int. J. Biol. Sci. 2026; 22(5): 2343-2360. doi:10.7150/ijbs.118613
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Targeting Macrophage-to-Myofibroblast Transition Mitigates Progression from Inflammation to Fibrosis in Rosacea
Chengqian Chen, Peiru Wang, Yajing Cao, Dongbin Sung, Yutong Yang, Jin Yang, Jia Liu, Yu Yan, Zhijie Ruan, Jie Dong, Jia Yan, Qihang Chang, Chunying Li, Xiaojing Liu, Xiuli Wang, Qingyu Zeng
Int. J. Biol. Sci. 2026; 22(5): 2361-2382. doi:10.7150/ijbs.128841
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BMP2-induced Adam12+ Fibroblasts Dictate Wound-associated Skin Scarring and Fibrosis
Jun-Yi Chen, Jin-Ru Song, Ke-Ai Li, Xue-Yan Xu, Ding-Heng Zhu, Lian Zhang, Zi-Shuo Chen, Qing Cheng, Liu-Yi Yao, Yi-Qi Shen, Zhili Rong, Bin Yang, Cheng-Cheng Deng
Int. J. Biol. Sci. 2026; 22(5): 2383-2397. doi:10.7150/ijbs.123725
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Neutrophil extracellular traps prime the ZBP1-cGAS sensor complex, triggering necroptosis and inflammatory injury in acute pancreatitis
Haoyu Zhang, Zheng Wang, Jiongdi Lu, Jie Li, Yuchen Jia, Xiaozhou Xie, Yixuan Ding, Feng Cao, Fei Li
Int. J. Biol. Sci. 2026; 22(5): 2398-2417. doi:10.7150/ijbs.122290
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O-GlcNAcylation stabilizes RSK4 by antagonizing GSK3β-mediated phosphorylation to enhance radioresistance in esophageal squamous cell carcinoma
Jin Liu, Duo Cao, Tianqi Xu, Junpeng Xu, Bowen Zhang, Xinya Yang, Pusong Zhao, Peng Wang, Ligang Chen, Qingge Jia, Mingyang Li
Int. J. Biol. Sci. 2026; 22(5): 2418-2434. doi:10.7150/ijbs.128078
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DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence
Pengbo Wang, Liming Yu, Kexin Cao, Xiaofan Guo, Lufan Sun, Shu Zhang, Tong Zhao, Yao Yu, Mengyao Xiong, Chang Liu, Naijin Zhang, Yingxian Sun, Guozhe Sun, Liu Cao
Int. J. Biol. Sci. 2026; 22(5): 2435-2451. doi:10.7150/ijbs.122298
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VCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma
Jaime Jiménez-Suárez, Francisco J. Cimas, José Joaquín Paricio, Borja Belandia, Yosra Berrouayel, Elena Arconada-Luque, Sofía Matilla-Almazán, Cesare Soffientini, Stefano Percio, Silvia Redondo-García, Natalia García-Flores, Cristina Garnés-García, Pablo Fernández-Aroca, Juan Jesús Martínez-Gómez, Antonio Fernández-Aramburo, Syong Hyun Nam-Cha, Elisabetta Rovida, Atanasio Pandiella, Azucena Esparís-Ogando, Sandro Pasquali, Juan Carlos Rodríguez-Manzaneque, Luis Del Peso, María José Ruiz-Hidalgo, Ricardo Sánchez-Prieto
Int. J. Biol. Sci. 2026; 22(5): 2452-2468. doi:10.7150/ijbs.121402
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Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury via Targeting SCD1-MUFA Axis to Suppress ER Stress
Xiaoya Jin, Hetian Xue, Xiaolin Shi, Yuchuan Zhou, Jialing Zhang, Liang Zeng, Xinglong Liu, Yuqi Xiao, Han Wang, Yue Zheng, Lina Wang, Yang Bai, Yan Pan, Jianghong Zhang, Yanwu Xu, Chunlin Shao
Int. J. Biol. Sci. 2026; 22(5): 2469-2491. doi:10.7150/ijbs.126269
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CD44/POU2F2/BCL9L axis mediates MIF-driven SPP1+TAM activation in colorectal cancer metastasis
Fan Zhang, Bingquan Zhao, Xueying Fan, Zhiqiang Shi, Peilan Guo, Haibo Zhang, Hiu-Yee Kwan, Zhongqiu Liu, Tao Su
Int. J. Biol. Sci. 2026; 22(5): 2492-2511. doi:10.7150/ijbs.116575
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Exploring Host-driven Immunopathological Factors Developing Severe Tuberculosis: Insights from Comparative Mouse Models
Hongmin Kim, Kee Woong Kwon, Hagyu Kim, WeonSeok Jung, Kyungmin Kim, Jung Joo Hong, Sung Jae Shin
Int. J. Biol. Sci. 2026; 22(5): 2512-2532. doi:10.7150/ijbs.124878
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Reviews
Gut-Lung Microbiota Axis Shapes the Immune Microenvironment and Immunotherapeutic Response in Lung Cancer
Yao Liu, Sidao Wang, Xuan Xiang, Yiheng Du, Qianqian Xue, Yiran Niu, Wenbei Peng, Linlin Ye, Qiong Zhou
Int. J. Biol. Sci. 2026; 22(5): 2265-2284. doi:10.7150/ijbs.126977
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Tumor-Induced Rewiring of Splenic Niches: from Immune Organ to Cancer Accomplice
Tong Yuan, Junjie Liu, Chunyu Zhang, Xing Lv, Guan Tan, Lin Xue, Erlei Zhang, Huifang Liang, Zhiyong Huang
Int. J. Biol. Sci. 2026; 22(5): 2533-2556. doi:10.7150/ijbs.127169
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