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Volume 22 (8); 2026

Research Papers

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SLC4A7 Drives NSCLC Progression and Immune Evasion via pH Dysregulation: Its Targeting Synergizes with Anti-PD-1/L1 Therapy Hao Qin, Dongfang Tang, Zheng Li, Fuzhi Yang, Jing Wang, Xiucheng Liu, Chang Chen, Wen Gao Int. J. Biol. Sci. 2026; 22(8): 3950-3968. doi:10.7150/ijbs.129129 Full text PDF

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CAF-derived exosomal circMPP6 drives ovarian cancer metastasis by coordinating nuclear and cytoplasmic regulation of ADAM22 to activate TGF-β/Smad signaling Xinyi Wei, Xin Chen, Yan Ren, Mengyan Tu, Shenglong Wu, Tianchen Guo, Simin Xiang, Weiguo Lu, Junfen Xu Int. J. Biol. Sci. 2026; 22(8): 3969-3989. doi:10.7150/ijbs.126013 Full text PDF

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LncRNA LMCD1-AS1 Interacts with PHF8 to Promote Hepatocellular Carcinoma Resistance to Multikinase Inhibitors Xiao Yang, Songze Song, Tianxing Ye, Xiujuan Zhang, Ziying Yang, Yue Mi, Yanjie Shen, Yanan Zhang, Jie Liu, Qinong Ye Int. J. Biol. Sci. 2026; 22(8): 3990-4003. doi:10.7150/ijbs.129651 Full text PDF

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Patchouli alcohol triggers autophagic cell death in non-small cell lung cancer cells through targeting GNAI1 to dissociate the GNAI1/ARRB1 complex Sheng Zhang, Lei Tang, Yunzhou Pu, Yu You, Hongyu Chen, Yongqi Chen, Yanqing Huang, Xiaodie Liu, Qing Song, Qing Ji, Liu Yang Int. J. Biol. Sci. 2026; 22(8): 4004-4024. doi:10.7150/ijbs.125690 Full text PDF

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Olfactory epithelium organoid models identify Ddit3 as a potential therapeutic target against inflammation-related olfactory sensory neuronal loss and functional deficit Jinxia Liu, Jiaming Qi, Nan Jiang, Yuzhen Wang, Weihao Li, Shiyi Tian, Liujing Zhuang, Yunfeng Zhang, Yongliang Liu, Yiqun Yu Int. J. Biol. Sci. 2026; 22(8): 4025-4042. doi:10.7150/ijbs.129192 Full text PDF

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A novel small-molecule inhibitor GSK-F1 confers radiosensitivity by inhibiting the NSUN2/TP53/RAD51 axis-mediated DNA homologous recombination repair in nasopharyngeal carcinoma Lemei Zheng, Mengna Li, Xiaolong Li, Jianxia Wei, Changning Xue, Qingqing Wei, Yumei Duan, Huizhen Xin, Zubing Wu, Ting Zeng, Wei Xiong, Songqing Fan, Ming Zhou, Hongyu Deng Int. J. Biol. Sci. 2026; 22(8): 4043-4058. doi:10.7150/ijbs.130087 Full text PDF

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Novel strategies for mitigating hepatic ischemia-reperfusion injury: targeting MICU1 and calcium-glycolytic homeostasis with acteoside Yinhao Zhang, Runping Liu, Yun Yang, Huayao Lu, Mengyu Guo, Hong Wang, Ranyi Luo, Xiaoyong Xue, Guifang Fan, Kaihong Xie, Jia Liu, Xiaojiaoyang Li Int. J. Biol. Sci. 2026; 22(8): 4074-4094. doi:10.7150/ijbs.126332 Full text PDF

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TGFβR Hyperactivation Drives CD103⁺/ITGB2⁺ TRM Cell Accumulation in High-Fat Diet-Exacerbated CIA Sijia Yan, Jielin Sun, Khan Zara Ahmad, Xuan Wang, Lei Tong, Qiangdongzi Mao, Qingwen Wang, Adeleh Divsalar, Edwin Cheung, Chaofu Wang, Xu Wang, Xianting Ding Int. J. Biol. Sci. 2026; 22(8): 4095-4115. doi:10.7150/ijbs.124386 Full text PDF

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HSPA6 Promotes Ferroptosis in Triple-Negative Breast Cancer by Rewiring Lipid Metabolism to Potentiate Membrane Lipid Peroxidation Lin-Yue Hai, Zhi-Hao Yu, Wen-Bo Liu, Yuan-Yuan Zhang, Yue Xu, Shan Cheng, Hao-Ran Yue, Zhang-Yin Guo, Shi-Jie Yan, Rui Sun, Xiao-Feng Liu, Bo-Wen Liu, Xin Wang, Xu-Chen Cao, Yue Yu Int. J. Biol. Sci. 2026; 22(8): 4168-4193. doi:10.7150/ijbs.129745 Full text PDF

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E2F3 activates NF-κB signaling through TRIM26 mediated TAB1 ubiquitination in pancreatic cancer Qiyue Zhang, Boping Jing, Dianyun Ren, Yan Sun, Hongkun Cai, Xueyi Liang, Yingke Zhou, Heshui Wu, Feng Guo Int. J. Biol. Sci. 2026; 22(8): 4243-4261. doi:10.7150/ijbs.127710 Full text PDF

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YAP1 converts circELP2-mediated biochemical signals to mechanical forces through promoting cytoskeleton remodeling in pulmonary fibrosis Ruiqiong Li, Songzi Zhang, Jinjin Zhang, Haitong Zhang, Yujie Wang, Changjun Lv, Bo Liu, Lihua Ren, Xiaodong Song, Fang Wang Int. J. Biol. Sci. 2026; 22(8): 4264-4288. doi:10.7150/ijbs.127193 Full text PDF

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Tumor Necrosis Factor Receptor 2 Inhibits HIV-1 Infection by Blocking the Binding of gp120 to CD4 Yang Gao, Zhonghao Chen, Yibo Chen, Yang Yang, Yiru Wang, Ci Zhu, Ping Liao, He Song, Xin Chen Int. J. Biol. Sci. 2026; 22(8): 4303-4314. doi:10.7150/ijbs.124330 Full text PDF

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Shear Stress Promotes Metastasis of Triple-negative Breast Cancer Cells Through Calcium Channel-ROS-FOS Axis Huaxing Xiong, Muya Zhou, Kathy Qian Luo Int. J. Biol. Sci. 2026; 22(8): 4315-4333. doi:10.7150/ijbs.127645 Full text PDF

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Impaired Alveolar Barrier Integrity Exposes FGFR1 Orchestrating Tight Junction Homeostasis via Occludin Transcription Maintenance Jiaqi Zhang, Yang Zhao, Yujie Bao, Bo Yang, Qiaojun He, Zizheng Gao, Bing Xia, Peihua Luo Int. J. Biol. Sci. 2026; 22(8): 4334-4345. doi:10.7150/ijbs.128209 Full text PDF

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HDAC1 Regulates Acquired Resistance to EGFR Inhibitors through the TFCP2-NDRG1 Signaling Axis in Pancreatic Cancer Taoyu Chen, Yuxuan Li, Yan Sun, Qixun Fu, Heshui Wu, Dan Li, Dianyun Ren Int. J. Biol. Sci. 2026; 22(8): 4346-4366. doi:10.7150/ijbs.131003 Full text PDF

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Fucoidan P Alleviates Sarcopenic Obesity by Regulating Muscle Protein and Energy Metabolism Jong-Yeon Kim, Sung-Min Kim, Sanghoon Lee, Ju-Hong Jeon, Eun-Jung Park, Hae-Jeung Lee Int. J. Biol. Sci. 2026; 22(8): 4367-4382. doi:10.7150/ijbs.125462 Full text PDF

Reviews

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A Darwinian Perspective on Tumor Evolution Amancio Carnero Int. J. Biol. Sci. 2026; 22(8): 3925-3949. doi:10.7150/ijbs.130014 Full text PDF

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Intestinal Ischemia/Reperfusion Injury: Mechanisms, Diagnosis, and Therapeutic Advances Fan Deng, Qi-Shun Sun, Sun Xie, Ling Wu, Shi-Ying He, Bo-Wei Zhou, Zhen Hu, Wan-Yi Lian, Bing-Jie Li, Cai Li, Wei -Feng Liu, Jing-Juan Hu, Ke-Xuan Liu Int. J. Biol. Sci. 2026; 22(8): 4059-4073. doi:10.7150/ijbs.130025 Full text PDF

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The Role of Exosomes in Offspring Metabolic Programming in Gestational Diabetes: Mechanisms and Potential Applications Jing Zhou, Dongmei Wang, Miao Yu, Xiao Zhai, Yingna Song, Jieying Liu, Xinhua Xiao Int. J. Biol. Sci. 2026; 22(8): 4116-4135. doi:10.7150/ijbs.131080 Full text PDF

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Exercise Impacts Liver Disease: Balancing Metabolic and Immune Homeostasis Chen Cheng, Wentao Xu, Shanshan Wu, Jia Gao, Jianshang Huang, Yunsheng Dong, Jingjing Ji, Li Zuo, Hua Wang Int. J. Biol. Sci. 2026; 22(8): 4148-4167. doi:10.7150/ijbs.126841 Full text PDF

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Ubiquitin-Modifying Enzymes as Cell-Fate Regulators in Intestinal Inflammation Chenchen Qian, Fangmin Ning, Yong Xu, Jingjing Shao, Binglu Shi, Chenjian Zhou, Yi Wang Int. J. Biol. Sci. 2026; 22(8): 4194-4224. doi:10.7150/ijbs.130460 Full text PDF

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Mechanosensitive Ion Channels: Molecular Hubs Integrating Skeletal Muscle Adaptation and Systemic Homeostasis Chong Zhao, Jinying Zhang, Xu Wang, Hongzhen Li, Jie Huang, Jiacheng Wang, Jianhao Wang, Haoran Zhang, Yan Zeng, Haiying Liu, Shuai Xu Int. J. Biol. Sci. 2026; 22(8): 4225-4242. doi:10.7150/ijbs.127875 Full text PDF

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Mechanistic insights into how intrapancreatic fat deposition drives the development of acute pancreatitis Xinyi Gu, Hongzhu Zhang, Wenjun Lin, Wangyang Chen, Chenyu Le, Zhicheng Huang, Qiang Liu, Jianfeng Yang Int. J. Biol. Sci. 2026; 22(8): 4289-4302. doi:10.7150/ijbs.131224 Full text PDF

Commentaries

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Multimodal AI mapping with GigaTIME reveals spatial immune signaling states in the tumor microenvironment Hakjin Kim, Seon-Kyu Kim, Jinhyuk Lee, Sung-Hwan Moon, Sun-Uk Kim, Taeho Kwon Int. J. Biol. Sci. 2026; 22(8): 4136-4138. doi:10.7150/ijbs.130729 Full text PDF

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Mitoxyperilysis: Rethinking oxidative stress as a spatially constrained lethal signal Chen-Yueh Wen, Meng-Yu Wu, Andy P. Tsai, Su-Boon Yong, Chia-Jung Li Int. J. Biol. Sci. 2026; 22(8): 4139-4143. doi:10.7150/ijbs.130535 Full text PDF

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AlphaGenome: a framework for integrated regulatory variant interpretation Taeho Kwon, Hakjin Kim, Sun-Uk Kim, Seon-Kyu Kim Int. J. Biol. Sci. 2026; 22(8): 4144-4147. doi:10.7150/ijbs.133555 Full text PDF

Letter to the Editor: Combination of FTO and BTK inhibitors synergistically suppresses the malignancy of breast cancer cells Meichen Liu, Ziqi Zhao Int. J. Biol. Sci. 2026; 22(8): 4262-4263. doi:10.7150/ijbs.132248 Full text PDF

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