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Volume 22 (6); 2026
Research Papers
IGF2BP2 Deficiency in Macrophages Impairs Migration, Reprograms Metabolism, and Limits Tumor Progression Hanna S. Schymik, Selina Wrublewsky, Marcus Höring, Gerhard Liebisch, Simon Both, Gilles Gasparoni, Caroline Bickelmann, Hanah Robertson, Charlotte Dahlem, Jörn Walter, Volkhard Helms, Matthias W. Laschke, Emmanuel Ampofo, Jessica Hoppstädter, Alexandra K. Kiemer
Int. J. Biol. Sci. 2026; 22(6): 2754-2773. doi:10.7150/ijbs.122142
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Targeting STARD10 Alleviates Steatotic Liver Injury by Suppressing YBX1/ACSL1-Mediated Ferroptosis Zhipeng Yang, Wenjie Zhang, Wenjie Gao, Junbo Song, Hongmin Kuang, Xin Hong, Liqiang Zhao, Chuheng Gou, Zhibin Lin, Quancheng Wang, Xuan Zhang, Kefeng Dou
Int. J. Biol. Sci. 2026; 22(6): 2786-2805. doi:10.7150/ijbs.127662
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Piezo1-Fstl1 Axis in Fracture Healing: Modulation of the Chondrocyte Inflammation-ROS-Mitochondrial Damage Cascade and Application of Smart Delivery System Tao Zhang, Haoran Wang, Guangzhao Hou, Siming Jia, Kai Ding, Qian Xiao, Jinbo Liu, Yajiang Dai, Gang Lv, Zhiyong Hou, Yingze Zhang, Juan Wang, Hongzhi Lv, Wei Chen
Int. J. Biol. Sci. 2026; 22(6): 2806-2826. doi:10.7150/ijbs.125814
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Identification of a Novel PDRG1-EZH2-p21 Pathway Controlling Senescence and Tumor Progression in Hepatocellular Carcinoma Qiang Yang, Lilong Zhang, Wei Li, Zhengle Zhang, Jing Tao, Yuping Rong, Weixing Wang
Int. J. Biol. Sci. 2026; 22(6): 2827-2841. doi:10.7150/ijbs.129113
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Clonotype-Resolved Single-Cell Multi-Omics Unlocks the Profile of Tumor-Infiltrating CD39⁺CD8⁺ T Cells and Enables Adoptive Cell Therapy for Solid Tumor Zihan Zhao, Xiangyu Wu, Qingyang Jin, Xin Yang, Wenjie Zhu, Ning Jiang, Tianyao Liu, Tianhang Li, Feng Fang, Hongqian Guo, Rong Yang
Int. J. Biol. Sci. 2026; 22(6): 2869-2884. doi:10.7150/ijbs.130389
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Synergistic Neurotoxicity of environmental Cadmium and Paraquat in Parkinsonism: Unveiling the Mito-ROS/OPA1/Caspase-3/GSDME-driven Apoptosis Axis Yufei Luo, Yingying Lu, Yancheng Tang, Xuejun Zhao, Junpu Wang, Yifan Liu, Sijia Jiang, Yuyuan Zhu, Jiaqi Qi, Linlin Xing, Chenghao Yan, Xu Liu, Cainian Huang, Haiji Wang, Haodong Xu, Liming Wang
Int. J. Biol. Sci. 2026; 22(6): 2885-2905. doi:10.7150/ijbs.126979
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Investigating the Mechanistic Link Between Lactate-Induced Histone Lactylation and Cellular Senescence in Osteoarthritis Chondrocytes: Implications for Therapy Rongtai Zuo, Chenliang Wu, Zhiqi Lin, Lingchi Kong, Feng Wang, Xuancheng Zhang, Jianxing Wei, Yi Lin, Erpeng Yang, Qinglin Kang, Shichang Zhao, Junjie Guan, Jinzhong Zhao
Int. J. Biol. Sci. 2026; 22(6): 2925-2949. doi:10.7150/ijbs.126483
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In vivo CRISPR/Cas9 Screening Reveals that UBE2L3 Modulates Autophagic Flux through TSC2 Ubiquitination and Potentiates PD-1 Blockade in Triple-Negative Breast Cancer Jian Xu, Ling Cheng, Sien Ma, Chen Gan, Jiaying Chai, Xinyi Zheng, Longyu Hu, Meiwen Ling, Mingjun Zhang, Bao Zhao, Huaidong Cheng
Int. J. Biol. Sci. 2026; 22(6): 2950-2969. doi:10.7150/ijbs.124937
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CFAP251 Deficiency Induces Male Infertility and PCD-like Ciliary Defects by Disrupting TUBB4B and SLC25A4 Recruitment in Humans and Mice Liting Liu, Zhanyu Wang, Yiling Zhou, Dongdong Tang, Rong Hua, Kuokuo Li, Guanxiong Wang, Fan Yang, Chunyu Liu, Yunxia Cao, Huan Wu, Yang Gao, Xiaojin He
Int. J. Biol. Sci. 2026; 22(6): 2970-2985. doi:10.7150/ijbs.128822
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Mechanistic Insights into the FOXM1/BUB1 axis-Mediated Oncogenic Signaling in Hepatocellular Carcinoma Shuping Wang, Yudong Mao, Tingyu Zeng, Tao Yong, Yu An, Jipin Li, Yuan Wang, Xiaojun Yang, Quanlin Guan
Int. J. Biol. Sci. 2026; 22(6): 2986-3012. doi:10.7150/ijbs.125454
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HMGA1 Activates FGFBP1 Transcription to Enhance Angiogenesis Induction and Tumor Progression via FGF2/FGFR1 Pathway Zhe Zhang, Yili Xiong, Mingyang Li, Shengyao Wang, Zhenxing Liu, Guanduo Wang, Huanqing Zhang, Xiaojuan Yang, Gangli Liu, Dongsheng Zhang, Haiwei Wu, Shengyun Huang
Int. J. Biol. Sci. 2026; 22(6): 3013-3031. doi:10.7150/ijbs.109079
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Budding Yeast Ubiquitin Ligases Rad5 and Rad18 Bind a Novel PCNA Surface, which Is Required for their Functions in DNA-Damage Tolerance Li Fan, Ying Du, Allison Novecosky, Yu Luo, Wei Xiao
Int. J. Biol. Sci. 2026; 22(6): 3032-3047. doi:10.7150/ijbs.124441
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Suppression of ASNS expression by VHL-mediated ubiquitination hinders the progression of renal cell carcinoma through enhancing JUP expression and inhibiting PI3K-AKT and MAPK pathways Wuping Yang, Tao Liu, Wenwei Ying, Minghao Lu, Dan Xia, Tianyu Tang, Ding Peng
Int. J. Biol. Sci. 2026; 22(6): 3048-3069. doi:10.7150/ijbs.129332
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Apigenin Suppresses Bladder Cancer via the SIRT6-NCOA2-PPARα Axis Ying Liu, Zhen-Duo Shi, Yun-Fei Wei, Si-Yuan Jiang, Harsh Patel, Qian-Zi Liu, Yang Dong, Yi-Fang Liu, Lin Hao, Shan Gao, Dong-Hua Yang, Qiang Li, Cong-Hui Han
Int. J. Biol. Sci. 2026; 22(6): 3070-3086. doi:10.7150/ijbs.128177
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FAM177A1 disrupts SIRT3-SOD2 signaling to drive mitochondrial dysfunction-mediated VSMC phenotypic switching in vascular remodeling Ruiqi Mao, Yi Guo, Ling Jiang, Shichen Bu, Ming Chen, Minglu Liang, Xinyuan Gao, Yichen Wu, Wenjing Xu, Zilong Chen, Kai Huang, Xiaoguang Li, Cheng Wang
Int. J. Biol. Sci. 2026; 22(6): 3108-3126. doi:10.7150/ijbs.128409
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CBX8 suppresses autophagy-dependent senescence in colorectal cancer by modulating the mTOR signaling pathway Tiankang Li, Enjian Zhang, Xin Liu, Hui Zhou, Pengbo Zhang, Chong Zhang, Xiuzhong Zhang, Nai Wu, Shuai Gong, Zeqiang Ren, Jie Ding, Yi Zhang
Int. J. Biol. Sci. 2026; 22(6): 3127-3143. doi:10.7150/ijbs.126032
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Orphan Nuclear Receptor NR4A1 Promotes Proliferation and Osteogenic Differentiation of Valvular Interstitial Cells through Activation of CCND2 Qiang Shen, Chao Zhang, Chen Jiang, Zongtao Liu, Lin Fan, Hanshen Luo, Xingyu Qian, Zhengfeng Fan, Dingyi Yao, Nianguo Dong, Jiawei Shi
Int. J. Biol. Sci. 2026; 22(6): 3174-3190. doi:10.7150/ijbs.122863
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Identification of Trogocytosis as an Essential Limitation Factor in hPSC-derived CAR Macrophages Baoqiang Kang, Shuoting Wang, Xinrui Guo, Huaisong Lin, Han Yan, Mingquan Wang, Tianhe Song, Zhishuai Zhang, Xing Hu, Yanling Zhu, Bo Feng, Jinfu Nie, Jiajun Liu, Guangjin Pan
Int. J. Biol. Sci. 2026; 22(6): 3191-3203. doi:10.7150/ijbs.127434
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Dietary targeting of CNBP to rein in the EREG-EGFR cascade and restore homeostasis in colitis-associated colorectal cancer Tao Zhang, Lisha Zhou, Boyang Wang, Meijing Wang, Yuyu Zhu, Yitong Liu, Tingyu Zhang, Qingyuan Liu, Chuang Xiao, Lingdong Kong, Qiang Xu, Bo Zhang, Jiao Qu, Shao Li, Yang Sun
Int. J. Biol. Sci. 2026; 22(6): 3204-3223. doi:10.7150/ijbs.128354
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A crosstalk between tumor cells and adipocytes facilitates tumor cell migration and invasion Laura Garrido-Jiménez, Beatriz del Valle-Pérez, Javier Pastor, Élida Alechaga, Aleix Sala-Vila, Óscar J. Pozo, Raúl Peña, Antonio García de Herreros
Int. J. Biol. Sci. 2026; 22(6): 3272-3287. doi:10.7150/ijbs.117604
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Caffeic Acid Modulates Protein Disulfide Isomerase-NLRP3 Inflammasome Signaling to Mitigate Inflammation in Acute Pneumonia Guanjun Li, Tong Yang, Ying Zhang, Ang Ma, Lirun Zhou, Chen Wang, Peng Gao, Cui Liu, Junzhe Zhang, Yin Hua Zhu, Huan Tang, Jigang Wang
Int. J. Biol. Sci. 2026; 22(6): 3288-3303. doi:10.7150/ijbs.101061
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Reviews
Pancreatic cancer-associated myofibroblasts: a review Marcin Banacki, Iwona Inkielewicz-Stepniak
Int. J. Biol. Sci. 2026; 22(6): 2774-2785. doi:10.7150/ijbs.121234
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Role of Copper Homeostasis and Cuproptosis in Cardiovascular Disease: Molecular Insights and Metabolic Perspectives Xianzhe Yu, Dou Yuan, Yabo Wang, Leibo Wang, Lingling Zhu, Qi An, Yunfei Ling
Int. J. Biol. Sci. 2026; 22(6): 2842-2868. doi:10.7150/ijbs.126580
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Orchestrating Tumor Metastasis: Exosomes as Master Regulators of the Local and Distant Microenvironment Yuanke Zhao, Aiyu Liu, Xi Zhang, Anqi Zeng, Linjiang Song
Int. J. Biol. Sci. 2026; 22(6): 2906-2924. doi:10.7150/ijbs.128203
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Metabolic-Immune Coupling in Urologic Cancers: Macrophage Reprogramming as a Therapeutic Nexus Wenxue Huang, Weijia Li, Wentai Shangguan, Lin Yang, Zhuohang Li, Boyuan Sun, Cunzhen Ma, Xunguo Yang, Peidan Peng, Jie Zhao, Bisheng Cheng, Peng Wu
Int. J. Biol. Sci. 2026; 22(6): 3087-3107. doi:10.7150/ijbs.127634
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Mitochondria transfer in tissue homeostasis and diseases Lei Qin, Donghao Gan, Zecai Chen, Zhen Xu, Mingyue Wu, Bimin Gao, Yufeng Long, Xihong Mou, Wenqing Li, Weihong Yi, Guozhi Xiao
Int. J. Biol. Sci. 2026; 22(6): 3144-3173. doi:10.7150/ijbs.129709
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Cellular and Molecular Neuro-Bone Cell Interactions Drive Alveolar Bone Remodeling During Orthodontic Mechanical Loading Xinyi Fang, Chi Liao, Jiamin Wan, Chunmiao Jiang, Yating Yi, Jun Wang, Qianming Chen, Jiu Lin, Xiaoyan Chen
Int. J. Biol. Sci. 2026; 22(6): 3224-3243. doi:10.7150/ijbs.129449
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Ubiquitin-conjugating Enzymes in Cancer Zhiyang Yao, Ti Peng, Hao Dong, Yong Liao, Kai Miao, Jiang-Jiang Qin, Xiaoqing Guan
Int. J. Biol. Sci. 2026; 22(6): 3244-3271. doi:10.7150/ijbs.130297
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