Mitochondrial Stat3, the Need for Design Thinking

Yang, Rui; Rincon, Mercedes

doi:10.7150/ijbs.15153

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Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

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Int J Biol Sci 2016; 12(5):532-544. doi:10.7150/ijbs.15153 This issue Cite

Review

Mitochondrial Stat3, the Need for Design Thinking

Rui Yang, Mercedes Rincon^✉

Department of Medicine/Immunobiology Program, University of Vermont, Burlington, VT, USA, 05405

Citation:

Yang R, Rincon M. Mitochondrial Stat3, the Need for Design Thinking. Int J Biol Sci 2016; 12(5):532-544. doi:10.7150/ijbs.15153. https://www.ijbs.com/v12p0532.htm

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Abstract

Stat3 has been studied extensively as a transcription factor, however the finding that Stat3 also localizes to mitochondria has opened a new area to discover non-classical functions. Here we review the current knowledge of mitochondrial Stat3 as a regulator of the electron transport chain (ETC) and its impact on mitochondrial production of ATP and ROS. We also describe recent findings identifying Stat3 as a regulator of mitochondrial Ca²⁺ homeostasis through its effect on the ETC. It is becoming evident that these non-classical functions of Stat3 can have a major impact on cancer progression, cardiovascular diseases, and inflammatory diseases. Therefore, mitochondrial Stat3 functions challenge the current design of therapies that solely target Stat3 as a transcription factor and suggest the need for “design thinking,” which leads to the development of novel strategies, to intervene the Stat3 pathway.

Keywords: Stat3

Citation styles

APA

Yang, R., Rincon, M. (2016). Mitochondrial Stat3, the Need for Design Thinking. International Journal of Biological Sciences, 12(5), 532-544. https://doi.org/10.7150/ijbs.15153.

ACS

Yang, R.; Rincon, M. Mitochondrial Stat3, the Need for Design Thinking. Int. J. Biol. Sci. 2016, 12 (5), 532-544. DOI: 10.7150/ijbs.15153.

NLM

Yang R, Rincon M. Mitochondrial Stat3, the Need for Design Thinking. Int J Biol Sci 2016; 12(5):532-544. doi:10.7150/ijbs.15153. https://www.ijbs.com/v12p0532.htm

CSE

Yang R, Rincon M. 2016. Mitochondrial Stat3, the Need for Design Thinking. Int J Biol Sci. 12(5):532-544.

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