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Volume 22 (10); 2026
Research Papers
Heparanase 2 (Hpa2) protects the exocrine pancreas from damages of Western diet and pancreatic cancer Yasmin Kayal, Malik Farhoud, Maali Odeh, Uri Barash, Inna Naroditsky, Rawan Bassal, Yasuhiko Nishioka, Ralph D Sanderson, Neta Ilan, Israel Vlodavsky
Int. J. Biol. Sci. 2026; 22(10): 4997-5014. doi:10.7150/ijbs.131032
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CXCL6 exacerbates metabolic dysfunction-associated steatohepatitis by suppressing LPIN1-mediated fatty acid oxidation in hepatocytes Ye Eun Cho, Min-Ju Kim, Yeonsoo Kim, Hyeokjin Lim, Yunseo Park, Sangok Kim, Seung-Jin Kim, Jin-Wook Yoo, Seungjin Ryu, Parkyong Song, Changwan Hong, Yong He, Haeseung Lee, Je-Yoel Cho, Seonghwan Hwang
Int. J. Biol. Sci. 2026; 22(10): 5015-5035. doi:10.7150/ijbs.129358
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YY1 Lactylation Elicits CARD9 Deficiency in Dendritic Cells Promoting Pancreatic Cancer Immune Escape Lingyan Ding, Cheng Tian, Yiting Feng, Ruochen Xu, Senlin Li, Mengzhu Zheng, Xiaoyan Wang, Qianqian Xu, Ming Xiang
Int. J. Biol. Sci. 2026; 22(10): 5036-5053. doi:10.7150/ijbs.131102
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The MCU-MECOM Axis Orchestrates Glioblastoma Progression by Remodeling Mitochondrial Dynamics and Quality Control via MAMs Xiaodong Li, Yaoliang Wang, Feifei Wu, Xin Huang, Ziwei Ni, Guangzhen Xu, Weizhong Wang, Jingjing Tie, Yunqiang Huang, Yuze Sun, Zhenhua Wang, Shujiao Li, Qianwen Zheng, Yuxuan Liu, Yousheng Wu, Chengrong Gong, Qingdong Guo, Yanling Yang, Yayun Wang
Int. J. Biol. Sci. 2026; 22(10): 5054-5082. doi:10.7150/ijbs.127940
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Alpha-ketoglutarate Potentiates IL-1β Production and Suppressive Mechanisms of Myeloid-Derived Suppressor Cells by Altering Redox Metabolism and Inducing Autophagy Marijana Milanović, Luka Pavlović, Marina Bekić, Jelena Đokić, Marija Stojadinović, Dušan Radojević, Miodrag Čolić, Sergej Tomić
Int. J. Biol. Sci. 2026; 22(10): 5119-5141. doi:10.7150/ijbs.127309
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A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis Lichao Yang, Qi Sun, Zhixian Jiang, Baojia Yao, Caimei Yang, Ganglei Liu, Lianwen Yuan
Int. J. Biol. Sci. 2026; 22(10): 5142-5160. doi:10.7150/ijbs.133562
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PSMC5 Orchestrates an Immunosuppressive Niche and Metastasis in Colorectal Cancer via SMURF1-Mediated K11-Linked Ubiquitination of METTL14 Yi Zhang, Xiao Yang, Hua Zhong, Chengsheng Ding, Ximo Xu, Yanfei Shao, Bin Sun, Wendong Zhang, Junjun Ma, Bo Feng, Minhua Zheng, Zirui He
Int. J. Biol. Sci. 2026; 22(10): 5182-5202. doi:10.7150/ijbs.130350
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Endothelial Klf9 fine-tunes Akt signaling to act as a transcriptional brake restraining retinal angiogenesis Honglian Wu, Tianjing Yang, Yuning Xun, Ming Zhou, Yutian Zhang, Xueming Yao, Yongsheng Chang, Yi Lei, Hua Yan
Int. J. Biol. Sci. 2026; 22(10): 5203-5227. doi:10.7150/ijbs.133293
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Redirecting Cholesterol Metabolism During Ex Vivo Biomanufacturing Enhances the Metabolic Fitness and Antitumor Efficacy of CAR-T Cells Yuge Zhu, Jiaxin Tu, Shuang Li, Shance Li, Bufan Xiao, Xuantong Zhou, Guanyu Zhang, Xinyu Li, You He, Nan Wu, Zheming Lu, Chaoting Zhang
Int. J. Biol. Sci. 2026; 22(10): 5228-5245. doi:10.7150/ijbs.132207
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Impaired redox adaptation through SLC38A5-dependent glutamine metabolism contributes to melatonin-mediated anoikis sensitivity and metastasis suppression in bone cancer Bao Tran Nguyen, Wei-Cheng Chen, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Chin-Jung Hsu, Kieu Thanh Huynh, Wei-Chien Huang, Shun-Fa Yang, Chih-Hsin Tang
Int. J. Biol. Sci. 2026; 22(10): 5246-5262. doi:10.7150/ijbs.133256
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Plasticity-Driven Regeneration of Circumvallate Papilla After Lgr5+ Stem Cells Loss Senthil Kumar Baskaran, Anish Ashok Adpaikar, Suyeon Lee, Junsu Kim, Yeo Song Lee, JooHyun Jee, Hidenori Akutsu, Thantrira Porntaveetus, Ki Woo Kim, Eun-Jung Kim, Jong-Min Lee, Han-Sung Jung
Int. J. Biol. Sci. 2026; 22(10): 5263-5282. doi:10.7150/ijbs.130382
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SIRT3 activation by oroxylin A phosphate diethyl ester triggers mitochondrial dysfunction and apoptosis in non-small cell lung cancer Chiang-Wen Lee, Yu-Feng Lin, Kuan-Han Lee, Ying-Sui Sun, Tsung-Ming Chang, Miao-Ching Chi, Zih-Chan Lin, Ayaho Yamamoto, Kuo-Ti Peng, Ju-Fang Liu
Int. J. Biol. Sci. 2026; 22(10): 5283-5300. doi:10.7150/ijbs.133993
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SREBP2-activated CNPY3 Phase Separation Promotes Colorectal Cancer by Enhancing MDM2-mediated p53 Degradation Xue Li, Min-Yue Yin, Yan-Fei Wei, Jie Xing, Qian Zhang, Ye Zong, Shu-Tian Zhang, Si-An Xie
Int. J. Biol. Sci. 2026; 22(10): 5301-5319. doi:10.7150/ijbs.125792
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PIP5K1A-PIP2-RhoA Signaling Orchestrates Membrane Remodeling during Early Porcine Embryo Development Cheng-Lin Zhan, Song-Hee Lee, Zheng-Wen Nie, Xiang-Shun Cui
Int. J. Biol. Sci. 2026; 22(10): 5320-5339. doi:10.7150/ijbs.129307
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A Scorpion Venom-Derived Peptide M6 Endowed with Anti-Aging Ability via Enhanced Antioxidant Activity in Cells, Caenorhabditis elegans and Mouse Models Siyuan Luo, Haixin Qin, Weimin Zuo, Viktor Prypoten, Raymond S. Norton, Yehuda G Assaraf, Hang Fai Kwok
Int. J. Biol. Sci. 2026; 22(10): 5340-5358. doi:10.7150/ijbs.133242
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The function of TLR2 and the microbiome in macrophage-dependent dissemination of nontuberculous mycobacterial gut infection Li Liu, Wanbin Hu, Herman P. Spaink
Int. J. Biol. Sci. 2026; 22(10): 5359-5384. doi:10.7150/ijbs.124776
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E3 ligase UHRF2 hijacks nuclear TBK1 to epigenetically repress type I interferons expression Wenwen Huang, Renjie Song, Qicong Shen, Yang Shi, Xi Wang, Nan Li, Qian Zhang, Xuetao Cao
Int. J. Biol. Sci. 2026; 22(10): 5385-5398. doi:10.7150/ijbs.135125
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VDR-Spermidine Axis Protects Against Age-Related Granulosa Cell Dysfunction and Follicular Decline via DNMTs-Mediated p53 Methylation Haiyun Chen, Qinghe Geng, Qiuyi Wang, Yuanqin Li, Luxi Shangguan, Zhengquan Zhu, Jingwen Zhang, Shuan Wang, Xiaotian Chen, Shanmei Shen, Yanting Wen, Daojuan Wang, Yong Wang
Int. J. Biol. Sci. 2026; 22(10): 5399-5420. doi:10.7150/ijbs.128631
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Fangchinoline Activates cGAS-STING to Promote Antitumor Immunity without Pathological Inflammation Yang Zhao, Xingyu Chen, Yunfei Xie, Tianyi Liu, Ying Luo, Zhengquan Liu, Yanyan Zhu, Lei Chen, Yuxiang Ren, Hanjie Liu, Pingsen Zhao, Qian Wang, Fuping You
Int. J. Biol. Sci. 2026; 22(10): 5444-5458. doi:10.7150/ijbs.133255
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Phase separation of p85β modulates hepatocellular carcinoma progression through POLR1A Yifan Zhang, Dong Zhang, Yi Duan, Gaoping Cui, Yanhua Zhang, Baoyu He, Meilian Yao, Xiangyu Li, Chengkun Chen, Zhe Li, Shiyi Yang, Jiahao Zheng, Jun Gu, Dongmei Zhang, Yongzhong Liu, Zhang Lin, Hualian Hang, Yujun Hao
Int. J. Biol. Sci. 2026; 22(10): 5459-5474. doi:10.7150/ijbs.130598
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SQSTM1/p62 UFMylation Enhances Autophagic Clearance of Pathogenic Mutant Huntingtin Xiaohui Wang, Xiaowei Lv, Honglv Jiang, Wenyun Zhu, Lindong Cao, Liang Zhou, Fang Lin, Rong Deng, Li-Fang Hu, Jingjing Ma, Jia-Bin Li, Guoqiang Xu
Int. J. Biol. Sci. 2026; 22(10): 5475-5494. doi:10.7150/ijbs.127110
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SPARC Drives Tubulointerstitial Fibrosis through Regulating the CBP-DOT1L Pathway Huimin Jiang, Qing Yang, Kuo Wang, Qinqin Tan, Chenyang Xiong, Xindi Zhou, Chun Gan, Han Xiao, Lan Qiu, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang, Qiu Li
Int. J. Biol. Sci. 2026; 22(10): 5495-5508. doi:10.7150/ijbs.133879
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Huaier Polysaccharides Sensitize Anti-PD-L1 Therapy via Promoting Antitumor Immune Response in Triple-Negative Breast Cancer Lin-xi Zhou, Zi-wei Wu, Yuan Tian, Ke-fei Luo, Qin-wen Pan, Yuan-yin Xi, Peng Tang, Ling-juan Zeng, Ling Zhong, Jun Jiang, Yi Zhang, Lingmi Hou, Hong Zheng, Ming-hao Wang
Int. J. Biol. Sci. 2026; 22(10): 5509-5524. doi:10.7150/ijbs.133068
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Biomembrane-coated Nanoparticles Targeting circHIF1α Suppress Ovarian Cancer Metastasis and Cisplatin Resistance by Mediating System Xc⁻ Inactivation via SLC7A11/SLC3A2 to Induce Ferroptosis in Cancer Stem Cells Yinyi Chang, Jingjing Wang, Liying Ma, Yi Liu, Yumeng Zhu, Yu Yi, Dongdong Zhang, Zitong Zhao, Li Sun, Yongmei Song
Int. J. Biol. Sci. 2026; 22(10): 5525-5547. doi:10.7150/ijbs.130412
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B3GNT6-Linked Multimodal Signatures Integrate Tissue Morphology and PTM-Related Transcriptomics to Stratify Tumor Kun Mei, Yipeng Xu, Renjun Gu, Zilu Chen, Foxing Tan, Zhuyan Shao, Jiahong Zhu, Xu Wang, Xigao Liu, Yan Huang, Xiaoxuan Yu, Hengrui Liu
Int. J. Biol. Sci. 2026; 22(10): 5548-5567. doi:10.7150/ijbs.134004
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Reprogramming Transcriptional Networks via CREB1 Lactylation at K122 Activates HMGB1-Mediated NETosis and Chemoresistance Jia-Mei Wang, Fu-Ying Zhao, Qi Zhang, Ye Yuan, Bai-Qiang Li, Ning Liu, Jing-Jie Li, Chuan Liu, Hua-Qin Wang
Int. J. Biol. Sci. 2026; 22(10): 5568-5594. doi:10.7150/ijbs.131303
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Impaired Neuregulin 1 Processing is Associated with Synaptic and Behavioral Abnormalities in a Prenatal Valproic Acid Model of Autism Yu-Jin Kim, Han-Byeol Kim, Hyo-Min Lim, Yoori Choi, Ran-Sook Woo
Int. J. Biol. Sci. 2026; 22(10): 5595-5614. doi:10.7150/ijbs.133137
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Reviews
Targeting Tumor-Associated Macrophages to Reshape the Immuno-Mechanical Landscape: Molecular Mechanisms and Therapeutic Strategies Guanghui Liu, Yang Yu, Zichen Guo, Lijuan Liu, Wujin Chen, Changgang Sun
Int. J. Biol. Sci. 2026; 22(10): 5083-5118. doi:10.7150/ijbs.132476
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Neutrophil Extracellular Traps in Pancreatic Ductal Adenocarcinoma: A Vicious Cycle in the Tumor Microenvironment and Targeted Interventions Lin Zhao, Haodong Yuan, Zixiang Chen, Xueli Xia, Xinyu Tian, Shengjun Wang
Int. J. Biol. Sci. 2026; 22(10): 5161-5181. doi:10.7150/ijbs.133035
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Gut microbial-derived metabolites: key players in kidney disease and renal fibrosis Wan-Ying Zhang, Yu-Lu Zhang, Qing-Qing Yu, Jing-Teng Zhou, Hua Miao, Li-Min Liu, Ying-Yong Zhao
Int. J. Biol. Sci. 2026; 22(10): 5421-5443. doi:10.7150/ijbs.133969
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