ISSN: 1449-2288International Journal of Biological Sciences
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Int J Biol Sci 2020; 16(4):543-552. doi:10.7150/ijbs.35256 This issue Cite
Research Paper
Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head
Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China
Citation:
Gao Y, Zhu H, Wang Q, Feng Y, Zhang C. Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head. Int J Biol Sci 2020; 16(4):543-552. doi:10.7150/ijbs.35256. https://www.ijbs.com/v16p0543.htm
Other stylesAbstract
Vascular injury is considered an important pathological process during glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH). In this study, we tried to investigate whether the endoplasmic reticulum (ER) stress is triggered in the GC-induced endotheliocyte (EC) apoptosis and ONFH. The results showed that a GC upregulated the expression of ER stress-related proteins, and PERK-CHOP signaling played an important role and induced EC apoptosis. The inhibition of PERK by GSK2656157 significantly decreased the GC-induced EC apoptosis in vitro and in vivo, thus protecting a rat model from vascular injury and significantly preventing GC-induced ONFH.
Keywords: glucocorticoid, osteonecrosis of femoral head, endoplasmic-reticulum stress, PERK signaling, endotheliocyte, apoptosis
Citation styles
APA
Gao, Y., Zhu, H., Wang, Q., Feng, Y., Zhang, C. (2020). Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head. International Journal of Biological Sciences, 16(4), 543-552. https://doi.org/10.7150/ijbs.35256.
ACS
Gao, Y.; Zhu, H.; Wang, Q.; Feng, Y.; Zhang, C. Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head. Int. J. Biol. Sci. 2020, 16 (4), 543-552. DOI: 10.7150/ijbs.35256.
NLM
Gao Y, Zhu H, Wang Q, Feng Y, Zhang C. Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head. Int J Biol Sci 2020; 16(4):543-552. doi:10.7150/ijbs.35256. https://www.ijbs.com/v16p0543.htm
CSE
Gao Y, Zhu H, Wang Q, Feng Y, Zhang C. 2020. Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head. Int J Biol Sci. 16(4):543-552.
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