Int J Biol Sci 2020; 16(5):730-738. doi:10.7150/ijbs.40923 This issue Cite

Review

Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease

Yu Wu1, Xinyue Liu1, Haoxiao Zheng1, Hailan Zhu1, Weiyi Mai2, Xiaohui Huang1✉, Yuli Huang1,3✉

1. Department of Cardiology, Shunde hospital, Southern Medical University, Jiazi Road 1 Lunjiao Town, Shunde District, Foshan, Guangdong, 528308, China.
2. Department of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou
3. The George Institute for Global Health, NSW 2042 Australia

Citation:
Wu Y, Liu X, Zheng H, Zhu H, Mai W, Huang X, Huang Y. Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease. Int J Biol Sci 2020; 16(5):730-738. doi:10.7150/ijbs.40923. https://www.ijbs.com/v16p0730.htm
Other styles

File import instruction

Abstract

Graphic abstract

The Wnt signaling pathway plays important roles in organ development and disease processes. Secreted frizzled-related protein 2 (sFRP2), a vital molecule of Wnt signaling, can regulate cardiac development and cardiovascular disease. Recent studies have suggested that sFRP2 is not only an antagonist of the canonical Wnt signaling pathway, but also has a more complex relationship in myocardial fibrosis, angiogenesis, cardiac hypertrophy and cardiac regeneration. Here, we review the role of sFRP2 and Wnt signaling in cardiac development and cardiovascular disease.

Keywords: Wnt Signaling, Secreted frizzled-related protein 2, Cardiac Fibrosis, Angiogenesis, Hypertrophy, Cardiac development


Citation styles

APA
Wu, Y., Liu, X., Zheng, H., Zhu, H., Mai, W., Huang, X., Huang, Y. (2020). Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease. International Journal of Biological Sciences, 16(5), 730-738. https://doi.org/10.7150/ijbs.40923.

ACS
Wu, Y.; Liu, X.; Zheng, H.; Zhu, H.; Mai, W.; Huang, X.; Huang, Y. Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease. Int. J. Biol. Sci. 2020, 16 (5), 730-738. DOI: 10.7150/ijbs.40923.

NLM
Wu Y, Liu X, Zheng H, Zhu H, Mai W, Huang X, Huang Y. Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease. Int J Biol Sci 2020; 16(5):730-738. doi:10.7150/ijbs.40923. https://www.ijbs.com/v16p0730.htm

CSE
Wu Y, Liu X, Zheng H, Zhu H, Mai W, Huang X, Huang Y. 2020. Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease. Int J Biol Sci. 16(5):730-738.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image