Int J Biol Sci
2020; 16(10):1718-1723.
doi:10.7150/ijbs.45123 This issueCite
Review
Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2
Guangyu Zhou1,2, Qi Zhao1,2✉
1. Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China. 2. Institute of Translational Medicine, University of Macau, Taipa, Macau SPR, China.
A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the SARS-CoV-2 show high homology with that of SARS-CoV. Current efforts are focusing on development of specific antiviral drugs. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. Further, we describe the benefits, challenges and considerations of NAbs against SARS-CoV-2. Although many challenges exist, NAbs still offer a therapeutic option to control the current pandemic and the possible re-emergence of the virus in the future, and their development therefore remains a high priority.
Keywords: Neutralizing antibody, SARS-CoV-2, COVID-19, severe acute respiratory syndrome
Citation styles
APA
Zhou, G., Zhao, Q. (2020). Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. International Journal of Biological Sciences, 16(10), 1718-1723. https://doi.org/10.7150/ijbs.45123.
ACS
Zhou, G.; Zhao, Q. Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. Int. J. Biol. Sci. 2020, 16 (10), 1718-1723. DOI: 10.7150/ijbs.45123.
NLM
Zhou G, Zhao Q. Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. Int J Biol Sci 2020; 16(10):1718-1723. doi:10.7150/ijbs.45123. https://www.ijbs.com/v16p1718.htm
CSE
Zhou G, Zhao Q. 2020. Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2. Int J Biol Sci. 16(10):1718-1723.
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