Int J Biol Sci 2020; 16(10):1718-1723. doi:10.7150/ijbs.45123 This issue
1. Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.
2. Institute of Translational Medicine, University of Macau, Taipa, Macau SPR, China.
A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the SARS-CoV-2 show high homology with that of SARS-CoV. Current efforts are focusing on development of specific antiviral drugs. Therapeutic neutralizing antibodies (NAbs) against SARS-CoV-2 will be greatly important therapeutic agents for the treatment of coronavirus disease 2019 (COVID-19). Herein, the host immune responses against SARS-CoV discussed in this review provide implications for developing NAbs and understanding clinical interventions against SARS-CoV-2. Further, we describe the benefits, challenges and considerations of NAbs against SARS-CoV-2. Although many challenges exist, NAbs still offer a therapeutic option to control the current pandemic and the possible re-emergence of the virus in the future, and their development therefore remains a high priority.
Keywords: Neutralizing antibody, SARS-CoV-2, COVID-19, severe acute respiratory syndrome