Int J Biol Sci 2021; 17(2):651-669. doi:10.7150/ijbs.52266 This issue

Review

Advancement and properties of circular RNAs in prostate cancer: An emerging and compelling frontier for discovering

Hong Zhou1,2,3#, Xu-dong Zheng2,3#, Chang-ming Lin4#, Jie Min5#, Shuang Hu2,3, Ying Hu2,3, Liang-yun Li2,3, Jia-si Chen2,3, Yu-min Liu2,3, Hao-dong Li2,3, Xiao-ming Meng2,3, Jun Li2,3, Ya-ru Yang6✉, Tao Xu2,3✉

1. Department of Pharmacy, Anhui Provincial Cancer Hospital, The First Affiliated Hospital of USTC West District, University of Science and Technology of China, Hefei 230031, China.
2. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.
3. Institute for Liver Diseases of Anhui Medical University, Hefei 230032, China.
4. Department of Urology, the Fourth Affiliated Hospital of Anhui Medical University, Hefei, 230011, China.
5. Department of Urology, The Second Hospital of Anhui Medical University, Hefei 230601, China.
6. Department of Clinical Trial Research Center, The Second Hospital of Anhui Medical University, Hefei, 230601, China.
#These authors contributed equally to this work.

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Citation:
Zhou H, Zheng Xd, Lin Cm, Min J, Hu S, Hu Y, Li Ly, Chen Js, Liu Ym, Li Hd, Meng Xm, Li J, Yang Yr, Xu T. Advancement and properties of circular RNAs in prostate cancer: An emerging and compelling frontier for discovering. Int J Biol Sci 2021; 17(2):651-669. doi:10.7150/ijbs.52266. Available from https://www.ijbs.com/v17p0651.htm

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Abstract

Graphic abstract

Prostate cancer (PC) is the most common carcinoma among men worldwide which results in 26% of leading causes of cancer-related death. However, the ideal and effective molecular marker remains elusive. CircRNA, initially observed in plant-infected viruses and Sendai virus in 1979, is generated from pre-mRNA back-splicing and comes in to play by adequate expression. The differential expression in prostate tissues compared with the control reveals the promising capacity in modulating processes including carcinogenesis and metastasis. However, the biological mechanisms of regulatory network in PC needs to systemically concluded. In this review, we enlightened the comprehensive studies on the definite mechanisms of circRNAs affecting tumor progression and metastasis. What's more, we validated the potential clinical application of circRNAs serving as diagnostic and prognostic biomarker. The discussion and analysis in circRNAs will broaden our knowledge of the pathogenesis of PC and further optimize the current therapies against different condition.

Keywords: circular RNA, prostate cancer (PC), biomarker, microRNA, tumorigenesis