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Int J Biol Sci 2021; 17(12):3188-3208. doi:10.7150/ijbs.62573 This issue Cite

Review

LncRNA H19: A novel oncogene in multiple cancers

Jun Yang1, Manlong Qi2, Xiang Fei3, Xia Wang3, Kefeng Wang3,✉

1. Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, China
2. Department of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang 110004, China
3. Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110004, China

✉ Corresponding author: Kefeng Wang, address: #36 Sanhao Street, Heping District, Shenyang, Liaoning, China. Email: wang.kefengcom. Tel: +86 18940254849, Fax: +86 24 31939077.

Citation:
Yang J, Qi M, Fei X, Wang X, Wang K. LncRNA H19: A novel oncogene in multiple cancers. Int J Biol Sci 2021; 17(12):3188-3208. doi:10.7150/ijbs.62573. https://www.ijbs.com/v17p3188.htm
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Abstract

Graphic abstract

Long non-coding RNAs (lncRNAs) are a series of non-coding RNAs that lack open reading frameworks. Accumulating evidence suggests important roles for lncRNAs in various diseases, including cancers. Recently, lncRNA H19 (H19) became a research focus due to its ectopic expression in human malignant tumors, where it functioned as an oncogene. Subsequently, H19 was confirmed to be involved in tumorigenesis and malignant progression in many tumors and had been implicated in promoting cell growth, invasion, migration, epithelial-mesenchymal transition, metastasis, and apoptosis. H19 also sequesters some microRNAs, facilitating a multilayer molecular regulatory mechanism. In this review, we summarize the abnormal overexpression of H19 in human cancers, which suggests wide prospects for further research into the diagnosis and treatment of cancers.

Keywords: lncRNA, H19, oncogene, cancers, metastasis

Citation styles

APA
Yang, J., Qi, M., Fei, X., Wang, X., Wang, K. (2021). LncRNA H19: A novel oncogene in multiple cancers. International Journal of Biological Sciences, 17(12), 3188-3208. https://doi.org/10.7150/ijbs.62573.

ACS
Yang, J.; Qi, M.; Fei, X.; Wang, X.; Wang, K. LncRNA H19: A novel oncogene in multiple cancers. Int. J. Biol. Sci. 2021, 17 (12), 3188-3208. DOI: 10.7150/ijbs.62573.

NLM
Yang J, Qi M, Fei X, Wang X, Wang K. LncRNA H19: A novel oncogene in multiple cancers. Int J Biol Sci 2021; 17(12):3188-3208. doi:10.7150/ijbs.62573. https://www.ijbs.com/v17p3188.htm

CSE
Yang J, Qi M, Fei X, Wang X, Wang K. 2021. LncRNA H19: A novel oncogene in multiple cancers. Int J Biol Sci. 17(12):3188-3208.

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