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Int J Biol Sci 2022; 18(11):4432-4451. doi:10.7150/ijbs.73093 This issue Cite

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Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance

Jinlin Jia1*, Suwen Wu2*, Zimo Jia3, Chang Wang1, Chenxi Ju1, Jinxiu Sheng1, Fucheng He1, Mingxia Zhou4✉, Jing He5✉

1. Department of Medical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2. Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
3. Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050017, China
4. Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
5. Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
*These authors contributed equally to this work.

✉ Corresponding authors: Jing He, Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. E-mail: jinghe16edu.cn; Mingxia Zhou, Department of Gastroenterology, The First Affiliated Hospital More

Citation:
Jia J, Wu S, Jia Z, Wang C, Ju C, Sheng J, He F, Zhou M, He J. Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance. Int J Biol Sci 2022; 18(11):4432-4451. doi:10.7150/ijbs.73093. https://www.ijbs.com/v18p4432.htm
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Abstract

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Accumulating evidence has revealed that m6A modification, the predominant RNA modification in eukaryotes, adds a novel layer of regulation to the gene expression. Dynamic and reversible m6A modification implements sophisticated and crucial functions in RNA metabolism, including generation, splicing, stability, and translation in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs). Furthermore, m6A modification plays a determining role in producing various m6A-labeling RNA outcomes, thereby affecting several functional processes, including tumorigenesis and progression. Herein, we highlighted current advances in m6A modification and the regulatory mechanisms underlying mRNAs and ncRNAs in distinct cancer stages. Meanwhile, we also focused on the therapeutic significance of m6A regulators in clinical cancer treatment.

Keywords: m6A, non-coding RNA, tumor microenvironment, therapeutic target

Citation styles

APA
Jia, J., Wu, S., Jia, Z., Wang, C., Ju, C., Sheng, J., He, F., Zhou, M., He, J. (2022). Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance. International Journal of Biological Sciences, 18(11), 4432-4451. https://doi.org/10.7150/ijbs.73093.

ACS
Jia, J.; Wu, S.; Jia, Z.; Wang, C.; Ju, C.; Sheng, J.; He, F.; Zhou, M.; He, J. Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance. Int. J. Biol. Sci. 2022, 18 (11), 4432-4451. DOI: 10.7150/ijbs.73093.

NLM
Jia J, Wu S, Jia Z, Wang C, Ju C, Sheng J, He F, Zhou M, He J. Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance. Int J Biol Sci 2022; 18(11):4432-4451. doi:10.7150/ijbs.73093. https://www.ijbs.com/v18p4432.htm

CSE
Jia J, Wu S, Jia Z, Wang C, Ju C, Sheng J, He F, Zhou M, He J. 2022. Novel insights into m6A modification of coding and non-coding RNAs in tumor biology: From molecular mechanisms to therapeutic significance. Int J Biol Sci. 18(11):4432-4451.

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