Int J Biol Sci 2022; 18(15):5849-5857. doi:10.7150/ijbs.77030 This issue
1. Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyaung University College of Medicine, Bucheon, Republic of Korea.
2. Department of Pediatrics, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
3. Department of Data Science, Sejong University College of Software Convergence, Seoul, Republic of Korea.
4. Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.
5. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.
6. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
7. Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Republic of Korea.
8. Yonsei Liver Center, Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea.
Solid organ transplant recipients generally show reduced immunogenicity to various vaccines. We aimed to assess the immunogenicity of the immune response among orthotopic liver transplant (OLT) recipients after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. A systematic search was performed to evaluate immunogenicity or adverse events reported after SARS-CoV-2 vaccination. The pooled analysis of 20 studies showed a humoral immune response rate of 0.70 (95% confidence interval [CI], 0.63-0.77) after SARS-CoV-2 vaccination among OLT recipients. The immunogenicity among OLT recipients was significantly lower compared to the overall population and healthy controls, with odds ratios (ORs) of 0.80 and 0.69. However, it was significantly higher than that of patients receiving other organ transplants, especially kidneys, with an OR of 1.50. Male sex, old age, chronic kidney disease, obesity, and multiple or high immunosuppressant doses significantly increased the risk of unresponsiveness in patients with OLT. The overall incidence of any adverse event after vaccination was 0.68 (95% CI, 0.55-0.81), similar to that of control. OLT recipients had an overall humoral immune response rate of 70% after SARS-CoV-2 vaccination, which is lower than that of healthy controls but favourable compared to those of other solid organ transplant recipients.
Keywords: Meta-analysis, liver transplant, vaccine, SARS-CoV-2, immunogenicity